(S)-Crizotinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0539906
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0308897
PCBP2 poly(rC) binding protein 2 0.0295845
CCNL1 cyclin L1 0.0241113
WDR43 WD repeat domain 43 0.0232149
NUP58 nucleoporin 58 0.0215275
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0201304
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0195353
BCLAF1 BCL2-associated transcription factor 1 0.0186926
MSN moesin 0.0176454
RNF145 ring finger protein 145 0.0174439
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0164896
ADAM17 ADAM metallopeptidase domain 17 0.016288
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0161671
HDGF hepatoma-derived growth factor 0.0156731
RAB6A RAB6A, member RAS oncogene family 0.015433
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.015249
PNN pinin, desmosome associated protein 0.0152485
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0152431
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0148639
EIF5 eukaryotic translation initiation factor 5 0.0145737
UBA6 ubiquitin-like modifier activating enzyme 6 0.0144302
KTN1 kinectin 1 (kinesin receptor) 0.0141707
APLP2 amyloid beta (A4) precursor-like protein 2 0.0139925
RTN4 reticulon 4 0.0139901
TPM3 tropomyosin 3 0.0136977
SRSF5 serine/arginine-rich splicing factor 5 0.0135851
FDPS farnesyl diphosphate synthase 0.0135431
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0133507
PDIA6 protein disulfide isomerase family A, member 6 0.0131677
SSRP1 structure specific recognition protein 1 0.0129209
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0122439
ZNF410 zinc finger protein 410 0.012101
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0118853
XPO1 exportin 1 0.0118559
CHN1 chimerin 1 0.0117429
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0116627
MSMO1 methylsterol monooxygenase 1 0.0115491
RPL3 ribosomal protein L3 0.0115333
RPL21 ribosomal protein L21 0.0113512
ADAM9 ADAM metallopeptidase domain 9 0.0111935
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0111702
RNPS1 RNA binding protein S1, serine-rich domain 0.0111026
NAMPT nicotinamide phosphoribosyltransferase 0.0110271
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0110108
ANXA5 annexin A5 0.0109782
NCEH1 neutral cholesterol ester hydrolase 1 0.0108587
SP3 Sp3 transcription factor 0.0106621
MATR3 matrin 3 0.0106509
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0106285
NCKAP1 NCK-associated protein 1 0.0105971
PRPF8 pre-mRNA processing factor 8 0.0104512
MIS18BP1 MIS18 binding protein 1 0.0103751
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.010252
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0102049
KIF23 kinesin family member 23 0.0101955
SQLE squalene epoxidase 0.0101717
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0101654
HP1BP3 heterochromatin protein 1, binding protein 3 0.0101467
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0101311
CASC3 cancer susceptibility candidate 3 0.010094
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0100663
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0100159
TBK1 TANK-binding kinase 1 0.00987315
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.00984411
ELOVL5 ELOVL fatty acid elongase 5 0.00973875
NPC1 Niemann-Pick disease, type C1 0.00965357
CABIN1 calcineurin binding protein 1 0.00964742
FXR1 fragile X mental retardation, autosomal homolog 1 0.00964587
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00953934
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.00951936
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.00950207
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.00946507
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00938442
NUP153 nucleoporin 153kDa 0.00936951
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00933233
KDM6A lysine (K)-specific demethylase 6A 0.00932837
SOAT2 sterol O-acyltransferase 2 0.00931052
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0092018
MYEF2 myelin expression factor 2 0.00918647
AZIN1 antizyme inhibitor 1 0.00906375
EZR ezrin 0.009007
KDM1A lysine (K)-specific demethylase 1A 0.00894189
HYOU1 hypoxia up-regulated 1 0.00887389
RCOR1 REST corepressor 1 0.00884791
SEC23A Sec23 homolog A (S. cerevisiae) 0.008805
SCAF4 SR-related CTD-associated factor 4 0.0087072
CENPI centromere protein I 0.00866792
SPAG5 sperm associated antigen 5 0.00866676
FADS2 fatty acid desaturase 2 0.00866385
SRSF11 serine/arginine-rich splicing factor 11 0.00864703
IMMT inner membrane protein, mitochondrial 0.00857262
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0085633
EIF5B eukaryotic translation initiation factor 5B 0.00853343
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.00849366
SNX3 sorting nexin 3 0.00848496
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.00843632
SHCBP1 SHC SH2-domain binding protein 1 0.00842042
AGFG1 ArfGAP with FG repeats 1 0.00833085
CDK1 cyclin-dependent kinase 1 0.00831372

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.317175
MT2A metallothionein 2A -0.284332
FTL ferritin, light polypeptide -0.195837
TMSB10 thymosin beta 10 -0.188813
VIM vimentin -0.125444
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12127
ACTG1 actin gamma 1 -0.118623
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.117507
IER3 immediate early response 3 -0.0969495
THSD4 thrombospondin, type I, domain containing 4 -0.0928875
RPL19 ribosomal protein L19 -0.088061
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0869371
TM4SF1 transmembrane 4 L six family member 1 -0.0839919
TFPI2 tissue factor pathway inhibitor 2 -0.0796421
EIF1 eukaryotic translation initiation factor 1 -0.0782947
TPT1 tumor protein, translationally-controlled 1 -0.0752098
PDE4D phosphodiesterase 4D, cAMP-specific -0.0669133
S100A6 S100 calcium binding protein A6 -0.0660183
RPLP1 ribosomal protein, large, P1 -0.0598521
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0589767
PTMA prothymosin, alpha -0.0568584
IGF2 insulin-like growth factor 2 -0.0565713
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0558606
DOCK4 dedicator of cytokinesis 4 -0.055727
RPS21 ribosomal protein S21 -0.0522451
CAVIN1 caveolae associated protein 1 -0.0510982
S100A10 S100 calcium binding protein A10 -0.0509655
RPL23 ribosomal protein L23 -0.0489139
CMIP c-Maf inducing protein -0.0487981
BASP1 brain abundant, membrane attached signal protein 1 -0.0483765
RPS8 ribosomal protein S8 -0.0465183
RPL35A ribosomal protein L35a -0.0453525
C15ORF48 chromosome 15 open reading frame 48 -0.0451539
KYNU kynureninase -0.0451351
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0417378
ASPH aspartate beta-hydroxylase -0.0412808
SVIL supervillin -0.0407698
DOCK5 dedicator of cytokinesis 5 -0.040712
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0396491
AHNAK AHNAK nucleoprotein -0.0390231
SAMD4A sterile alpha motif domain containing 4A -0.0388218
RPL8 ribosomal protein L8 -0.0377178
HLA-B major histocompatibility complex, class I, B -0.0371846
ANXA2 annexin A2 -0.0362468
RPS27A ribosomal protein S27a -0.0358071
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0356958
MYL12B myosin, light chain 12B, regulatory -0.0351096
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0349313
IGFBP3 insulin-like growth factor binding protein 3 -0.0345726
RPS29 ribosomal protein S29 -0.0339159
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0336854
RPL34 ribosomal protein L34 -0.0335189
DENND4A DENN/MADD domain containing 4A -0.0327276
BICC1 BicC family RNA binding protein 1 -0.0326466
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0322753
EGFR epidermal growth factor receptor -0.0309356
MAML3 mastermind-like 3 (Drosophila) -0.0309037
RPL11 ribosomal protein L11 -0.0306103
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0302653
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0301224
RPS25 ribosomal protein S25 -0.0300693
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0299979
RAB1A RAB1A, member RAS oncogene family -0.029875
FAM107B family with sequence similarity 107, member B -0.0297702
LMNA lamin A/C -0.029305
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0288326
GLIS3 GLIS family zinc finger 3 -0.0287173
RPS24 ribosomal protein S24 -0.0286374
RPL26 ribosomal protein L26 -0.0284929
CFLAR CASP8 and FADD-like apoptosis regulator -0.0284832
RPL32 ribosomal protein L32 -0.0284432
DST dystonin -0.0282863
RPL31 ribosomal protein L31 -0.0277769
LOC112694756 uncharaterized LOC112694756 -0.027588
GRAMD1B GRAM domain containing 1B -0.0275735
RPS15 ribosomal protein S15 -0.0273263
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271955
CUX1 cut-like homeobox 1 -0.0271327
LDHA lactate dehydrogenase A -0.027117
FNDC3B fibronectin type III domain containing 3B -0.026941
RPLP0 ribosomal protein, large, P0 -0.0267954
SERF2 small EDRK-rich factor 2 -0.0267699
TPM4 tropomyosin 4 -0.026686
FTH1 ferritin, heavy polypeptide 1 -0.0265758
PTK2 protein tyrosine kinase 2 -0.0265337
PM20D1 peptidase M20 domain containing 1 -0.026475
RPS16 ribosomal protein S16 -0.0263364
RPL36 ribosomal protein L36 -0.0261203
USP34 ubiquitin specific peptidase 34 -0.0260964
PARD3 par-3 family cell polarity regulator -0.0260595
S100A9 S100 calcium binding protein A9 -0.0260547
RAD21 RAD21 homolog (S. pombe) -0.0259402
STC1 stanniocalcin 1 -0.0257969
SLC38A2 solute carrier family 38, member 2 -0.0254253
RPS5 ribosomal protein S5 -0.0250217
APP amyloid beta (A4) precursor protein -0.0250141
UBC ubiquitin C -0.0249218
RPL7 ribosomal protein L7 -0.024886
FUS FUS RNA binding protein -0.0245114
RPS19 ribosomal protein S19 -0.0244964