| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | (S)-Crizotinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the (S)-Crizotinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.145747 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.125625 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.124867 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.103733 |
| PTMA | prothymosin, alpha | 0.0811962 |
| KYNU | kynureninase | 0.0780407 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0776546 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0768548 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0756252 |
| KRT17 | keratin 17, type I | 0.0753237 |
| ENO1 | enolase 1, (alpha) | 0.0752956 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0700125 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0658862 |
| PGK1 | phosphoglycerate kinase 1 | 0.0624873 |
| CDH13 | cadherin 13 | 0.0598466 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0587573 |
| EZR | ezrin | 0.0541554 |
| NDRG1 | N-myc downstream regulated 1 | 0.0523958 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0517942 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0487105 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0482734 |
| B2M | beta-2-microglobulin | 0.0481122 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0480071 |
| STC1 | stanniocalcin 1 | 0.046682 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0454883 |
| CLINT1 | clathrin interactor 1 | 0.0449212 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0448693 |
| SEPTIN7 | septin 7 | 0.044474 |
| EFNA5 | ephrin-A5 | 0.0444457 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0427988 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.042483 |
| RPN2 | ribophorin II | 0.0424546 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0423686 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.041913 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0418352 |
| RBM39 | RNA binding motif protein 39 | 0.0412618 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0399001 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0397345 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0391174 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0386749 |
| SETD5 | SET domain containing 5 | 0.0386582 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.03838 |
| NAV1 | neuron navigator 1 | 0.0382384 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0382112 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0379964 |
| NAV2 | neuron navigator 2 | 0.037926 |
| PRRC2C | proline-rich coiled-coil 2C | 0.037822 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.03773 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0375939 |
| TXNIP | thioredoxin interacting protein | 0.0375141 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0374313 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0373559 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0371477 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0364892 |
| RPL12 | ribosomal protein L12 | 0.0363066 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0359747 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0354642 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0353923 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0352434 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0350766 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0343908 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0343604 |
| PARD3 | par-3 family cell polarity regulator | 0.0340207 |
| PTEN | phosphatase and tensin homolog | 0.0339346 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0337144 |
| USP3 | ubiquitin specific peptidase 3 | 0.0336581 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.033557 |
| DENND4A | DENN/MADD domain containing 4A | 0.0334559 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0331861 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0329154 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0329036 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0324802 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.0323976 |
| RPL19 | ribosomal protein L19 | 0.0319821 |
| MSN | moesin | 0.0319321 |
| GLG1 | golgi glycoprotein 1 | 0.0317507 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0314945 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0314657 |
| SRP54 | signal recognition particle 54kDa | 0.0314491 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0311667 |
| S100A9 | S100 calcium binding protein A9 | 0.0306573 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0303337 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0301697 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0299013 |
| HELZ | helicase with zinc finger | 0.0297696 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0296427 |
| TPD52 | tumor protein D52 | 0.0296205 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0294665 |
| NCKAP1 | NCK-associated protein 1 | 0.0294229 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0293561 |
| CD46 | CD46 molecule, complement regulatory protein | 0.029193 |
| RLF | rearranged L-myc fusion | 0.0290623 |
| RNF149 | ring finger protein 149 | 0.0289157 |
| FRY | furry homolog (Drosophila) | 0.0286597 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0284767 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0281033 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0277704 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.027685 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0274806 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0273026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.226432 |
| FN1 | fibronectin 1 | -0.21172 |
| LMO7 | LIM domain 7 | -0.147383 |
| EGFR | epidermal growth factor receptor | -0.102648 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0938003 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0842156 |
| LAMC2 | laminin, gamma 2 | -0.0817963 |
| ABHD17C | abhydrolase domain containing 17C | -0.0769397 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.075815 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0675974 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0644783 |
| ATOSA | atos homolog A | -0.063238 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0617711 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0614467 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0612408 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0609606 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0595292 |
| TXNRD1 | thioredoxin reductase 1 | -0.0581989 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0543375 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0541269 |
| FBXO11 | F-box protein 11 | -0.0521935 |
| RPL35A | ribosomal protein L35a | -0.0514319 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0513953 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0513841 |
| SQSTM1 | sequestosome 1 | -0.0510797 |
| FLNB | filamin B, beta | -0.0506506 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.049617 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0467952 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0457273 |
| ACTG1 | actin gamma 1 | -0.0454104 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0449311 |
| NPTN | neuroplastin | -0.0441962 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0438025 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0428172 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0419173 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0408612 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0405695 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0404667 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0402459 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.040068 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0399802 |
| MMP12 | matrix metallopeptidase 12 | -0.0397321 |
| GPHN | gephyrin | -0.0391047 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0390279 |
| TAOK3 | TAO kinase 3 | -0.0387984 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0387596 |
| ADM | adrenomedullin | -0.0387208 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0384796 |
| FAT1 | FAT atypical cadherin 1 | -0.038175 |
| APP | amyloid beta (A4) precursor protein | -0.0377974 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0374979 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0372398 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.036625 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0364386 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0363864 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0358645 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0354826 |
| ATF6 | activating transcription factor 6 | -0.0353795 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0350217 |
| ERBIN | erbb2 interacting protein | -0.0347672 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0344755 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0343393 |
| JAK1 | Janus kinase 1 | -0.0337862 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0335225 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0335147 |
| SBF2 | SET binding factor 2 | -0.0329155 |
| RUNX1 | runt-related transcription factor 1 | -0.0328975 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0328777 |
| BPTF | bromodomain PHD finger transcription factor | -0.0328544 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0328415 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0317461 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0317095 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0316249 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0315474 |
| ABI1 | abl-interactor 1 | -0.0312325 |
| CD44 | CD44 molecule (Indian blood group) | -0.0309737 |
| SFTPA2 | surfactant protein A2 | -0.0307482 |
| SMYD3 | SET and MYND domain containing 3 | -0.0303523 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0301204 |
| MXD1 | MAX dimerization protein 1 | -0.0298707 |
| AHNAK | AHNAK nucleoprotein | -0.0298006 |
| MEF2A | myocyte enhancer factor 2A | -0.0297436 |
| RNF145 | ring finger protein 145 | -0.0296996 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0296286 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0291465 |
| MYO1E | myosin IE | -0.028966 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0289055 |
| RPL38 | ribosomal protein L38 | -0.0285972 |
| RPS16 | ribosomal protein S16 | -0.0282284 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0282199 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0278851 |
| FAM13A | family with sequence similarity 13, member A | -0.0277824 |
| PATJ | PATJ crumbs cell polarity complex component | -0.027689 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0275964 |
| PTK2 | protein tyrosine kinase 2 | -0.0273747 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0271127 |
| RAB10 | RAB10, member RAS oncogene family | -0.0268715 |
| ANO6 | anoctamin 6 | -0.0266691 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0266569 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0265309 |
