(S)-Crizotinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the (S)-Crizotinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.175144
AKAP12 A kinase (PRKA) anchor protein 12 0.0980533
RTN4 reticulon 4 0.0814975
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0735351
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0609558
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0495215
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0479303
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0456206
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0448703
SREBF2 sterol regulatory element binding transcription factor 2 0.042499
RUSC2 RUN and SH3 domain containing 2 0.0420226
RPS6 ribosomal protein S6 0.0413939
TMEM41B transmembrane protein 41B 0.0390221
KPNB1 karyopherin (importin) beta 1 0.037817
MSN moesin 0.0377538
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0370625
NAMPT nicotinamide phosphoribosyltransferase 0.0366795
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0361247
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0359444
TBK1 TANK-binding kinase 1 0.0357733
RAB6A RAB6A, member RAS oncogene family 0.0355608
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0336197
TMEM165 transmembrane protein 165 0.0331976
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0322665
RPLP0 ribosomal protein, large, P0 0.0315965
WDR43 WD repeat domain 43 0.0315609
ANXA5 annexin A5 0.0314469
NUP58 nucleoporin 58 0.0308624
ERRFI1 ERBB receptor feedback inhibitor 1 0.030235
BBX bobby sox homolog (Drosophila) 0.0300273
CCNL1 cyclin L1 0.0298154
MMP12 matrix metallopeptidase 12 0.0293045
JMJD1C jumonji domain containing 1C 0.0292955
EGR1 early growth response 1 0.0289555
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0288196
ADAM17 ADAM metallopeptidase domain 17 0.028589
SNX9 sorting nexin 9 0.0280214
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0275881
ZNF292 zinc finger protein 292 0.0275436
ARF4 ADP-ribosylation factor 4 0.0275087
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0274987
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0268648
NCKAP1 NCK-associated protein 1 0.0264656
FDPS farnesyl diphosphate synthase 0.0263873
LATS2 large tumor suppressor kinase 2 0.0263428
RASAL2 RAS protein activator like 2 0.0261227
EIF1 eukaryotic translation initiation factor 1 0.0257199
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0251853
SPPL3 signal peptide peptidase like 3 0.0249776
CDCP1 CUB domain containing protein 1 0.024848
TPI1 triosephosphate isomerase 1 0.0247484
RICTOR RPTOR independent companion of MTOR, complex 2 0.0247481
GOLGA4 golgin A4 0.024613
FAM13A family with sequence similarity 13, member A 0.0243539
TAGLN2 transgelin 2 0.0243042
ANKRD12 ankyrin repeat domain 12 0.0241806
SPRED2 sprouty-related, EVH1 domain containing 2 0.0240321
KDM6A lysine (K)-specific demethylase 6A 0.0239986
XPO1 exportin 1 0.0239718
MT2A metallothionein 2A 0.0238312
GARS1 glycyl-tRNA synthetase 1 0.0238084
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0237027
TNPO3 transportin 3 0.0236909
CTTNBP2NL CTTNBP2 N-terminal like 0.0236271
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0235925
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0233185
RPL35A ribosomal protein L35a 0.0232888
GATAD2B GATA zinc finger domain containing 2B 0.0232081
CDYL chromodomain protein, Y-like 0.0231552
IMMT inner membrane protein, mitochondrial 0.0230223
MED13L mediator complex subunit 13-like 0.0224642
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0224439
RNF38 ring finger protein 38 0.0224201
ZFAND3 zinc finger, AN1-type domain 3 0.0224151
LPIN1 lipin 1 0.0223045
ADAM9 ADAM metallopeptidase domain 9 0.0221759
IGF2 insulin-like growth factor 2 0.0221268
SLC38A1 solute carrier family 38, member 1 0.0220689
ANKRD28 ankyrin repeat domain 28 0.0218871
THOC1 THO complex 1 0.0216406
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0214715
RLIM ring finger protein, LIM domain interacting 0.0214629
RPS27 ribosomal protein S27 0.0214248
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0214181
KMT2E lysine (K)-specific methyltransferase 2E 0.0213902
ATXN2 ataxin 2 0.0212903
PLS3 plastin 3 0.0211754
INSIG1 insulin induced gene 1 0.0211692
RAI1 retinoic acid induced 1 0.0211647
KMT5B lysine methyltransferase 5B 0.0211636
ETNK1 ethanolamine kinase 1 0.0211221
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0207673
SIN3A SIN3 transcription regulator family member A 0.0206762
GLO1 glyoxalase I 0.0205893
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.020417
TMEM39A transmembrane protein 39A 0.020123
CENPF centromere protein F, 350/400kDa 0.0200037
WSB1 WD repeat and SOCS box containing 1 0.0197832
FTH1 ferritin, heavy polypeptide 1 0.0197481
SENP6 SUMO1/sentrin specific peptidase 6 0.0197125

decreased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.143999
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.13417
UBC ubiquitin C -0.130616
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.130216
MCL1 myeloid cell leukemia 1 -0.118179
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0961299
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0913367
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.08974
YBX3 Y box binding protein 3 -0.0861746
RPS27A ribosomal protein S27a -0.0818672
AEBP2 AE binding protein 2 -0.0762415
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0747103
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0735576
RIMS2 regulating synaptic membrane exocytosis 2 -0.0730703
TMSB10 thymosin beta 10 -0.0683596
PRELID2 PRELI domain containing 2 -0.0674956
ACTG1 actin gamma 1 -0.0653437
CANX calnexin -0.0650811
AHNAK AHNAK nucleoprotein -0.0647086
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0643428
INTS6 integrator complex subunit 6 -0.0628473
PDE10A phosphodiesterase 10A -0.0611432
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0587338
AFF3 AF4/FMR2 family, member 3 -0.0574224
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0562087
NAP1L1 nucleosome assembly protein 1-like 1 -0.0537656
PTMA prothymosin, alpha -0.0519989
RAD51B RAD51 paralog B -0.0514483
PRH1 proline-rich protein HaeIII subfamily 1 -0.0505017
WWOX WW domain containing oxidoreductase -0.0490159
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0489013
TAS2R14 taste receptor, type 2, member 14 -0.0475333
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0472207
ATXN1 ataxin 1 -0.0451369
EEF2 eukaryotic translation elongation factor 2 -0.0447058
EXOC4 exocyst complex component 4 -0.0443864
IGF1R insulin-like growth factor 1 receptor -0.0443203
WNT2B wingless-type MMTV integration site family, member 2B -0.0440882
KDM4B lysine (K)-specific demethylase 4B -0.0433257
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0428829
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0422206
THSD4 thrombospondin, type I, domain containing 4 -0.0415345
PDLIM5 PDZ and LIM domain 5 -0.0411759
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0409644
RYR3 ryanodine receptor 3 -0.0408786
USP34 ubiquitin specific peptidase 34 -0.0406546
STYK1 serine/threonine/tyrosine kinase 1 -0.0404697
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0403325
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0401868
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0401019
PDIA4 protein disulfide isomerase family A, member 4 -0.0400058
PRKCE protein kinase C, epsilon -0.0399251
NCOA7 nuclear receptor coactivator 7 -0.0392773
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0392762
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.038851
CDK12 cyclin-dependent kinase 12 -0.0388366
EML4 echinoderm microtubule associated protein like 4 -0.0384934
ENO1 enolase 1, (alpha) -0.0384586
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0380795
HMGA2 high mobility group AT-hook 2 -0.0379273
TRIP12 thyroid hormone receptor interactor 12 -0.0377043
FUS FUS RNA binding protein -0.0369561
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0367609
FMNL2 formin-like 2 -0.0365477
VCP valosin containing protein -0.0365062
SPIDR scaffolding protein involved in DNA repair -0.0358779
ZNF638 zinc finger protein 638 -0.0356794
DOCK5 dedicator of cytokinesis 5 -0.0354275
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0353748
RNF213 ring finger protein 213 -0.0349235
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0348404
HDAC4 histone deacetylase 4 -0.0346382
NEK10 NIMA-related kinase 10 -0.0345615
CTTN cortactin -0.0343541
RPS3 ribosomal protein S3 -0.0338752
SMYD3 SET and MYND domain containing 3 -0.0338584
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0337258
UBAP2L ubiquitin associated protein 2-like -0.0330486
DIAPH2 diaphanous-related formin 2 -0.032589
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0325418
SPDYA speedy/RINGO cell cycle regulator family member A -0.0322631
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0321903
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0321756
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0321031
DOCK1 dedicator of cytokinesis 1 -0.0318061
RRM2 ribonucleotide reductase M2 -0.0315632
MAP4 microtubule-associated protein 4 -0.0313687
DNAH14 dynein, axonemal, heavy chain 14 -0.0313631
BLTP2 bridge-like lipid transfer protein family member 2 -0.0310785
NF1 neurofibromin 1 -0.030873
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0308217
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0306884
RBM39 RNA binding motif protein 39 -0.0305771
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0304184
LARP4B La ribonucleoprotein domain family, member 4B -0.0303101
WWTR1 WW domain containing transcription regulator 1 -0.0295359
MBD5 methyl-CpG binding domain protein 5 -0.0294349
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0293599
TBC1D22A TBC1 domain family, member 22A -0.0293328
ATP11A ATPase, class VI, type 11A -0.0291233