(S)-Crizotinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.119334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.115498
NDRG1 N-myc downstream regulated 1 0.111585
NAMPT nicotinamide phosphoribosyltransferase 0.10942
FNDC3B fibronectin type III domain containing 3B 0.0823819
FN1 fibronectin 1 0.0789515
FAM13A family with sequence similarity 13, member A 0.0681046
TSC22D2 TSC22 domain family, member 2 0.067108
ELL2 elongation factor, RNA polymerase II, 2 0.062525
MSN moesin 0.0588386
FXR1 fragile X mental retardation, autosomal homolog 1 0.0572528
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0549149
UBA6 ubiquitin-like modifier activating enzyme 6 0.0532939
TFG TRK-fused gene 0.0531
RNF145 ring finger protein 145 0.0527578
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0516674
CCNL1 cyclin L1 0.0516469
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0510601
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0474745
USP3 ubiquitin specific peptidase 3 0.0464345
PCBP2 poly(rC) binding protein 2 0.0435871
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0435826
APLP2 amyloid beta (A4) precursor-like protein 2 0.042494
ADAM9 ADAM metallopeptidase domain 9 0.0420304
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0407727
MSMO1 methylsterol monooxygenase 1 0.0395903
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0387403
RYBP RING1 and YY1 binding protein 0.0375884
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0371761
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0369396
KDM6A lysine (K)-specific demethylase 6A 0.0366618
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.035797
LDHA lactate dehydrogenase A 0.035258
GARS1 glycyl-tRNA synthetase 1 0.0350298
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0350002
CDC73 cell division cycle 73 0.0349449
ZNF292 zinc finger protein 292 0.0349174
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0348441
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0346359
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.034485
MATR3 matrin 3 0.0331412
ANXA5 annexin A5 0.0330143
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0328943
SNX9 sorting nexin 9 0.0318577
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0318549
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0317639
BHLHE40 basic helix-loop-helix family, member e40 0.031129
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0308283
NUP58 nucleoporin 58 0.0306882
EEF2 eukaryotic translation elongation factor 2 0.0298669
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0298465
TRA2B transformer 2 beta homolog (Drosophila) 0.0297685
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.029739
QKI QKI, KH domain containing, RNA binding 0.0294281
GRB10 growth factor receptor-bound protein 10 0.0285548
SSBP2 single-stranded DNA binding protein 2 0.0285528
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0285297
ARRDC3 arrestin domain containing 3 0.028196
ECT2 epithelial cell transforming 2 0.0281123
UGCG UDP-glucose ceramide glucosyltransferase 0.0279649
RICTOR RPTOR independent companion of MTOR, complex 2 0.0273924
PDIA6 protein disulfide isomerase family A, member 6 0.0269836
ASPH aspartate beta-hydroxylase 0.0266472
PAPOLA poly(A) polymerase alpha 0.0266311
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0264815
VEGFA vascular endothelial growth factor A 0.0263401
RAD23B RAD23 homolog B (S. cerevisiae) 0.0261081
NCKAP1 NCK-associated protein 1 0.0258889
CD46 CD46 molecule, complement regulatory protein 0.0253046
UPP1 uridine phosphorylase 1 0.0252614
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0252138
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0252132
PTK2 protein tyrosine kinase 2 0.0250779
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0249487
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0246288
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0246203
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0246114
CPNE8 copine VIII 0.0243721
CDK17 cyclin-dependent kinase 17 0.0243067
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0242688
ATP13A3 ATPase type 13A3 0.0242392
RHOA ras homolog family member A 0.0242103
PRRC1 proline-rich coiled-coil 1 0.0239409
TOP1 topoisomerase (DNA) I 0.0235215
TXNRD1 thioredoxin reductase 1 0.0233996
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0229865
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0229364
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0227076
WAC WW domain containing adaptor with coiled-coil 0.0222347
CLINT1 clathrin interactor 1 0.022051
KMT2E lysine (K)-specific methyltransferase 2E 0.0219324
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0217373
OSBPL9 oxysterol binding protein-like 9 0.0216841
SPOPL speckle-type POZ protein-like 0.0216157
CENPF centromere protein F, 350/400kDa 0.0216073
TNIP1 TNFAIP3 interacting protein 1 0.0215879
EPS8 epidermal growth factor receptor pathway substrate 8 0.0213361
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0212466
FOSL1 FOS-like antigen 1 0.0209989
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0209384

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.194517
PTMA prothymosin, alpha -0.168302
TMSB10 thymosin beta 10 -0.153964
FTL ferritin, light polypeptide -0.153716
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.117202
EXT1 exostosin glycosyltransferase 1 -0.113341
LPP LIM domain containing preferred translocation partner in lipoma -0.110998
SAMD4A sterile alpha motif domain containing 4A -0.105235
LIMCH1 LIM and calponin homology domains 1 -0.103793
TPT1 tumor protein, translationally-controlled 1 -0.103454
FBXO32 F-box protein 32 -0.0833842
RPL35A ribosomal protein L35a -0.0773571
TMSB4X thymosin beta 4, X-linked -0.073435
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0690526
RPL34 ribosomal protein L34 -0.0673369
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.066506
S100A6 S100 calcium binding protein A6 -0.0654138
TPM4 tropomyosin 4 -0.0626749
RPLP1 ribosomal protein, large, P1 -0.058782
LMO7 LIM domain 7 -0.0575038
IFI6 interferon, alpha-inducible protein 6 -0.0554951
LAMB3 laminin, beta 3 -0.0548031
MYO1E myosin IE -0.0547372
RPS29 ribosomal protein S29 -0.0537155
VCL vinculin -0.0531726
RPS8 ribosomal protein S8 -0.0531194
WSB1 WD repeat and SOCS box containing 1 -0.052826
EFNA5 ephrin-A5 -0.0525191
SOX4 SRY (sex determining region Y)-box 4 -0.0515473
S100A10 S100 calcium binding protein A10 -0.0514824
GNAS GNAS complex locus -0.0510933
CCND1 cyclin D1 -0.0507541
EIF1 eukaryotic translation initiation factor 1 -0.0506682
IFI27 interferon, alpha-inducible protein 27 -0.0490072
ARHGAP5 Rho GTPase activating protein 5 -0.0489433
CSTB cystatin B (stefin B) -0.0457002
BASP1 brain abundant, membrane attached signal protein 1 -0.0452433
RPLP2 ribosomal protein, large, P2 -0.0449292
TM4SF1 transmembrane 4 L six family member 1 -0.0448489
KRT7 keratin 7, type II -0.0439176
HLA-B major histocompatibility complex, class I, B -0.0432741
LMNA lamin A/C -0.0432154
FBXO34 F-box protein 34 -0.0430066
PDLIM5 PDZ and LIM domain 5 -0.0428114
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0424692
ALCAM activated leukocyte cell adhesion molecule -0.042021
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0420182
RAB7A RAB7A, member RAS oncogene family -0.0409276
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0402111
RPS19 ribosomal protein S19 -0.0400738
CEP350 centrosomal protein 350kDa -0.0397661
RPL37 ribosomal protein L37 -0.0389971
ISG15 ISG15 ubiquitin-like modifier -0.0385903
FNIP1 folliculin interacting protein 1 -0.0385313
IFI16 interferon, gamma-inducible protein 16 -0.0384132
RPS13 ribosomal protein S13 -0.0381641
CAVIN1 caveolae associated protein 1 -0.0381593
RPS3 ribosomal protein S3 -0.0381374
SEC31A SEC31 homolog A (S. cerevisiae) -0.0378005
RPL9 ribosomal protein L9 -0.0373335
PALLD palladin, cytoskeletal associated protein -0.0371949
RAI14 retinoic acid induced 14 -0.0366946
CTNND1 catenin (cadherin-associated protein), delta 1 -0.036477
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0357001
ARHGAP20 Rho GTPase activating protein 20 -0.0356192
CANX calnexin -0.0347336
SQSTM1 sequestosome 1 -0.0345934
AFF1 AF4/FMR2 family, member 1 -0.0345129
GOLGB1 golgin B1 -0.0341705
TTC3 tetratricopeptide repeat domain 3 -0.0338841
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0336314
HLA-E major histocompatibility complex, class I, E -0.0329041
ETV6 ets variant 6 -0.0325484
RPL8 ribosomal protein L8 -0.0325482
MX2 MX dynamin-like GTPase 2 -0.0323854
MT2A metallothionein 2A -0.0316626
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.031457
ERBIN erbb2 interacting protein -0.0314086
RIGI RNA sensor RIG-I -0.0313871
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0313364
RPL37A ribosomal protein L37a -0.031256
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0309031
RPS27A ribosomal protein S27a -0.0308953
RNF213 ring finger protein 213 -0.030856
IFITM3 interferon induced transmembrane protein 3 -0.0307777
RPL19 ribosomal protein L19 -0.0304572
IFIH1 interferon induced with helicase C domain 1 -0.0304544
RBM47 RNA binding motif protein 47 -0.0303063
CUX1 cut-like homeobox 1 -0.0302572
RPS6 ribosomal protein S6 -0.0300945
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0297733
AHNAK2 AHNAK nucleoprotein 2 -0.0294789
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0292665
FBXL20 F-box and leucine-rich repeat protein 20 -0.0292112
CDK13 cyclin-dependent kinase 13 -0.0290868
MAP4 microtubule-associated protein 4 -0.0290287
TBCA tubulin folding cofactor A -0.0288044
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0288042
CD63 CD63 molecule -0.028695
PATJ PATJ crumbs cell polarity complex component -0.0286829