(S)-Crizotinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the (S)-Crizotinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.202423
EFNA5 ephrin-A5 0.14834
ASPH aspartate beta-hydroxylase 0.146488
TXNRD1 thioredoxin reductase 1 0.138143
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.136036
MYOF myoferlin 0.100191
TRIO trio Rho guanine nucleotide exchange factor 0.0896014
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0821189
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0807733
GDA guanine deaminase 0.0806928
NRCAM neuronal cell adhesion molecule 0.0777421
GRAMD1B GRAM domain containing 1B 0.0768077
NEK7 NIMA-related kinase 7 0.0767299
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0751821
LIMCH1 LIM and calponin homology domains 1 0.0710963
FNDC3B fibronectin type III domain containing 3B 0.0679989
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0658908
PM20D1 peptidase M20 domain containing 1 0.0647727
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.062318
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0620798
RTN4 reticulon 4 0.0594498
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0577817
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0573624
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0544566
CD109 CD109 molecule 0.0538755
COL5A2 collagen, type V, alpha 2 0.0525487
CENPF centromere protein F, 350/400kDa 0.050527
CTSC cathepsin C 0.0496207
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0491135
CXCL8 chemokine (C-X-C motif) ligand 8 0.0490307
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0474973
TOP2A topoisomerase (DNA) II alpha 170kDa 0.046012
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.045876
LDHA lactate dehydrogenase A 0.0458643
IGFBP3 insulin-like growth factor binding protein 3 0.0453847
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0450405
PCBP2 poly(rC) binding protein 2 0.0448437
PTGR1 prostaglandin reductase 1 0.0448346
FLNB filamin B, beta 0.0439377
COL8A1 collagen, type VIII, alpha 1 0.0425971
TNPO1 transportin 1 0.0420729
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0418747
PSD3 pleckstrin and Sec7 domain containing 3 0.0417099
ZEB2 zinc finger E-box binding homeobox 2 0.0405764
ESYT2 extended synaptotagmin-like protein 2 0.04044
EZR ezrin 0.0403625
ELL2 elongation factor, RNA polymerase II, 2 0.03962
MSN moesin 0.039216
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0385985
PTEN phosphatase and tensin homolog 0.0383798
AGFG1 ArfGAP with FG repeats 1 0.0379684
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0370445
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0369958
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0369444
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0369161
ZNF292 zinc finger protein 292 0.0365207
COL4A6 collagen, type IV, alpha 6 0.036424
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0355062
MFF mitochondrial fission factor 0.0355054
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0340469
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0340381
FAM13A family with sequence similarity 13, member A 0.0338819
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0334719
ITPRID2 ITPR interacting domain containing 2 0.0333425
CARD16 caspase recruitment domain family, member 16 0.0332117
NBAS neuroblastoma amplified sequence 0.0330743
GOLGA4 golgin A4 0.0330601
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0330518
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.032932
COPA coatomer protein complex, subunit alpha 0.032266
MKI67 marker of proliferation Ki-67 0.0320915
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0319672
AVL9 AVL9 homolog (S. cerevisiase) 0.0317624
BIRC6 baculoviral IAP repeat containing 6 0.0317485
SLF1 SMC5-SMC6 complex localization factor 1 0.0316115
SFPQ splicing factor proline/glutamine-rich 0.0307971
ENO1 enolase 1, (alpha) 0.030711
RBM39 RNA binding motif protein 39 0.0303381
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0302914
ANKRD28 ankyrin repeat domain 28 0.0302484
WDFY2 WD repeat and FYVE domain containing 2 0.0301097
ERRFI1 ERBB receptor feedback inhibitor 1 0.0299748
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0298187
PRRC2C proline-rich coiled-coil 2C 0.0296955
KMT2C lysine (K)-specific methyltransferase 2C 0.029647
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0287468
USP9X ubiquitin specific peptidase 9, X-linked 0.028668
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0286307
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0286144
DOCK4 dedicator of cytokinesis 4 0.0282102
DPY19L1 dpy-19-like 1 (C. elegans) 0.0278441
TFPI2 tissue factor pathway inhibitor 2 0.0278153
ENAH enabled homolog (Drosophila) 0.0276317
PGK1 phosphoglycerate kinase 1 0.0275058
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0272806
OGA O-GlcNAcase 0.0268348
NPAS2 neuronal PAS domain protein 2 0.0265076
SPAG9 sperm associated antigen 9 0.0260425
XPO1 exportin 1 0.0258929
ARHGAP29 Rho GTPase activating protein 29 0.0257811

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.238868
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.122691
CDH13 cadherin 13 -0.095453
TPT1 tumor protein, translationally-controlled 1 -0.0872564
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0747717
PDE4D phosphodiesterase 4D, cAMP-specific -0.0692857
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0663691
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0645638
ADGRD1 adhesion G protein-coupled receptor D1 -0.0601255
FN1 fibronectin 1 -0.0551291
VIM vimentin -0.0513924
AUTS2 autism susceptibility candidate 2 -0.0512679
TMSB10 thymosin beta 10 -0.043112
RPL31 ribosomal protein L31 -0.0414108
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0414078
RPS24 ribosomal protein S24 -0.0398439
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0375702
PRKN parkin RBR E3 ubiquitin protein ligase -0.0365666
RPL26 ribosomal protein L26 -0.0360714
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0347881
SMAD2 SMAD family member 2 -0.0339741
RPLP1 ribosomal protein, large, P1 -0.0334934
RPS8 ribosomal protein S8 -0.0319354
PTPRM protein tyrosine phosphatase, receptor type, M -0.0318266
RPL37A ribosomal protein L37a -0.0315631
RPL35A ribosomal protein L35a -0.0313843
CUX1 cut-like homeobox 1 -0.0311287
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0307747
VCL vinculin -0.0304736
INTS6 integrator complex subunit 6 -0.0304582
RPL34 ribosomal protein L34 -0.0296551
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.028845
SMOC1 SPARC related modular calcium binding 1 -0.0286532
TTC28 tetratricopeptide repeat domain 28 -0.0284073
HLA-B major histocompatibility complex, class I, B -0.027901
DENND1A DENN/MADD domain containing 1A -0.0278862
MAML3 mastermind-like 3 (Drosophila) -0.0275564
PRELID2 PRELI domain containing 2 -0.026675
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0266536
AEBP2 AE binding protein 2 -0.0263742
SOX6 SRY (sex determining region Y)-box 6 -0.0263473
P3H2 prolyl 3-hydroxylase 2 -0.0260964
LSAMP limbic system-associated membrane protein -0.0258513
NCKAP5 NCK-associated protein 5 -0.025616
FMNL2 formin-like 2 -0.025179
MAP7 microtubule-associated protein 7 -0.0245612
XYLT1 xylosyltransferase I -0.0242149
PCDH15 protocadherin-related 15 -0.0236264
RPS16 ribosomal protein S16 -0.0233732
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0231141
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0230041
PTMA prothymosin, alpha -0.0228542
RPL9 ribosomal protein L9 -0.022681
PCDH9 protocadherin 9 -0.0226546
RPS19 ribosomal protein S19 -0.022565
RAB31 RAB31, member RAS oncogene family -0.0225248
RPL7A ribosomal protein L7a -0.0224038
NT5C2 5'-nucleotidase, cytosolic II -0.0223374
RPL37 ribosomal protein L37 -0.0220336
PDLIM5 PDZ and LIM domain 5 -0.0219513
SOX4 SRY (sex determining region Y)-box 4 -0.0215436
RPL36A ribosomal protein L36a -0.0211793
EXT1 exostosin glycosyltransferase 1 -0.0208479
OXSR1 oxidative stress responsive 1 -0.0205848
PCBP3 poly(rC) binding protein 3 -0.020573
RPS23 ribosomal protein S23 -0.0204695
HDAC4 histone deacetylase 4 -0.0204287
CADM2 cell adhesion molecule 2 -0.0196185
GLRX glutaredoxin (thioltransferase) -0.0193545
CHL1 cell adhesion molecule L1-like -0.0192815
RPL12 ribosomal protein L12 -0.0192764
RPS12 ribosomal protein S12 -0.0192729
RPS25 ribosomal protein S25 -0.0190489
RPL19 ribosomal protein L19 -0.0189861
RPS6 ribosomal protein S6 -0.0189241
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0188191
RPS3 ribosomal protein S3 -0.0187871
RAD51B RAD51 paralog B -0.0184273
RPS27A ribosomal protein S27a -0.0181338
RPS17 ribosomal protein S17 -0.0181062
RANBP17 RAN binding protein 17 -0.0179337
RPS29 ribosomal protein S29 -0.0177714
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.017692
ACTG1 actin gamma 1 -0.0176884
SVIL supervillin -0.0176808
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0176117
FSTL4 follistatin-like 4 -0.01731
AGTPBP1 ATP/GTP binding protein 1 -0.0171139
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0170619
DST dystonin -0.0168226
WARS1 tryptophanyl-tRNA synthetase 1 -0.0166556
DNAH11 dynein, axonemal, heavy chain 11 -0.0163062
RPS21 ribosomal protein S21 -0.0162737
C9ORF153 chromosome 9 open reading frame 153 -0.0162693
SQSTM1 sequestosome 1 -0.0161496
HMGA2 high mobility group AT-hook 2 -0.0160962
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0158252
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0157278
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0156065
FNDC3A fibronectin type III domain containing 3A -0.0155046