(S)-Crizotinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

194 genes differentially expressed following the (S)-Crizotinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.173124
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.125862
TFPI2 tissue factor pathway inhibitor 2 0.118114
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.11009
STAU1 staufen double-stranded RNA binding protein 1 0.109138
UBA6 ubiquitin-like modifier activating enzyme 6 0.108352
SFTPA2 surfactant protein A2 0.104003
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0999721
APP amyloid beta (A4) precursor protein 0.0960564
ENAH enabled homolog (Drosophila) 0.094924
ZNF292 zinc finger protein 292 0.0943106
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0943037
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0892843
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0890895
CDC73 cell division cycle 73 0.0867207
WAC WW domain containing adaptor with coiled-coil 0.0844523
KMT2C lysine (K)-specific methyltransferase 2C 0.0819033
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.081665
CLTC clathrin, heavy chain (Hc) 0.0815951
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0810736
EZR ezrin 0.0798261
AHR aryl hydrocarbon receptor 0.0789693
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.074714
KIF13A kinesin family member 13A 0.0735753
NEK7 NIMA-related kinase 7 0.0735045
ANKRD17 ankyrin repeat domain 17 0.0732603
TSC22D2 TSC22 domain family, member 2 0.0730903
KMT2E lysine (K)-specific methyltransferase 2E 0.0723667
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0681795
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.067706
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.067467
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0670038
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0666792
FAT1 FAT atypical cadherin 1 0.0662521
FN1 fibronectin 1 0.0642963
RAB1A RAB1A, member RAS oncogene family 0.0642487
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0630331
SPAG9 sperm associated antigen 9 0.05742
EPS8 epidermal growth factor receptor pathway substrate 8 0.0565454
TRA2A transformer 2 alpha homolog (Drosophila) 0.0556654
FTH1 ferritin, heavy polypeptide 1 0.0549279
TFG TRK-fused gene 0.0537719
MACF1 microtubule-actin crosslinking factor 1 0.051767
LDHA lactate dehydrogenase A 0.0505975
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0504548
PCBP2 poly(rC) binding protein 2 0.0494108
CLMN calmin (calponin-like, transmembrane) 0.0490645
NDRG1 N-myc downstream regulated 1 0.0483135
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0476561
RTN4 reticulon 4 0.0463272
USP3 ubiquitin specific peptidase 3 0.0450533
ARID4B AT rich interactive domain 4B (RBP1-like) 0.04447
NAP1L1 nucleosome assembly protein 1-like 1 0.0424461
DSCAM Down syndrome cell adhesion molecule 0.0413225
ZMYND8 zinc finger, MYND-type containing 8 0.0399307
NAMPT nicotinamide phosphoribosyltransferase 0.0394827
PDIA3 protein disulfide isomerase family A, member 3 0.0380581
PRRC2C proline-rich coiled-coil 2C 0.0379037
KDM3A lysine (K)-specific demethylase 3A 0.037306
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0372526
KTN1 kinectin 1 (kinesin receptor) 0.0350417
SETD5 SET domain containing 5 0.0334817
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0298083
STC1 stanniocalcin 1 0.0259126
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0254107
CD44 CD44 molecule (Indian blood group) 0.0237184
PTK2 protein tyrosine kinase 2 0.0220557
ERRFI1 ERBB receptor feedback inhibitor 1 0.0213659
NFIA nuclear factor I/A 0.0208119
ARHGAP26 Rho GTPase activating protein 26 0.0206191
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0203503
MYO1E myosin IE 0.0189984
DIAPH2 diaphanous-related formin 2 0.0187138
JMJD1C jumonji domain containing 1C 0.0183476
CXCL8 chemokine (C-X-C motif) ligand 8 0.0183391
PTMA prothymosin, alpha 0.0159122
TBC1D22A TBC1 domain family, member 22A 0.0128533
ANXA2 annexin A2 0.0115925
PRELID2 PRELI domain containing 2 0.0111358
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.00923331
RPL23 ribosomal protein L23 0.00699088
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00657466
ZCCHC7 zinc finger, CCHC domain containing 7 0.00656198
RPS8 ribosomal protein S8 0.00543895
MED13 mediator complex subunit 13 0.00529744
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00374056
PGK1 phosphoglycerate kinase 1 0.00336811
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0031746
RAD51B RAD51 paralog B 0.00282522
EXOC6B exocyst complex component 6B 0.0024078
KANSL1 KAT8 regulatory NSL complex subunit 1 0.00201114
ACTG1 actin gamma 1 0.00172135
RPL19 ribosomal protein L19 0.00145504
ESYT2 extended synaptotagmin-like protein 2 1.03582E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.171902
IGF2 insulin-like growth factor 2 -0.170391
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.162476
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.153783
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.14517
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.119813
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.119684
IGFBP3 insulin-like growth factor binding protein 3 -0.0945574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0924782
CANX calnexin -0.0923761
FNDC3B fibronectin type III domain containing 3B -0.0898138
PDE4D phosphodiesterase 4D, cAMP-specific -0.0854255
FTL ferritin, light polypeptide -0.0845665
ELL2 elongation factor, RNA polymerase II, 2 -0.0845324
DST dystonin -0.0803693
OGA O-GlcNAcase -0.0762512
CCNI cyclin I -0.0731861
PSD3 pleckstrin and Sec7 domain containing 3 -0.0731484
ASPH aspartate beta-hydroxylase -0.0712648
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0697315
FNDC3A fibronectin type III domain containing 3A -0.0689161
TENM3 teneurin transmembrane protein 3 -0.0659275
MT2A metallothionein 2A -0.0648714
GPC6 glypican 6 -0.0642731
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0626123
ANKRD12 ankyrin repeat domain 12 -0.0613994
NALF1 NALCN channel auxiliary factor 1 -0.061235
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0605166
FAM13A family with sequence similarity 13, member A -0.0600971
RAB10 RAB10, member RAS oncogene family -0.0597237
TRIO trio Rho guanine nucleotide exchange factor -0.0586911
RPL26 ribosomal protein L26 -0.0576005
DOCK5 dedicator of cytokinesis 5 -0.0575927
TMSB10 thymosin beta 10 -0.0573902
WSB1 WD repeat and SOCS box containing 1 -0.0572401
MAML2 mastermind-like 2 (Drosophila) -0.0570238
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0562147
NCOR1 nuclear receptor corepressor 1 -0.056085
HOOK2 hook microtubule-tethering protein 2 -0.0551523
TPT1 tumor protein, translationally-controlled 1 -0.0540127
EFNA5 ephrin-A5 -0.0538029
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0535453
EXT1 exostosin glycosyltransferase 1 -0.0518538
EIF1 eukaryotic translation initiation factor 1 -0.0503833
KDM4C lysine (K)-specific demethylase 4C -0.0494609
AKAP12 A kinase (PRKA) anchor protein 12 -0.0485046
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0465553
ZBTB20 zinc finger and BTB domain containing 20 -0.0456087
TPR translocated promoter region, nuclear basket protein -0.0455126
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0453756
NF1 neurofibromin 1 -0.0450677
EEF2 eukaryotic translation elongation factor 2 -0.0447108
BIRC6 baculoviral IAP repeat containing 6 -0.0446185
RPS6 ribosomal protein S6 -0.0424814
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0417977
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.041722
AFF4 AF4/FMR2 family, member 4 -0.0416818
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0416042
EGFR epidermal growth factor receptor -0.0404336
AKAP13 A kinase (PRKA) anchor protein 13 -0.0401346
AKAP9 A kinase (PRKA) anchor protein 9 -0.0396081
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0382631
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0377783
RPL35A ribosomal protein L35a -0.036977
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0342585
KDM2A lysine (K)-specific demethylase 2A -0.03398
PKM pyruvate kinase, muscle -0.0336442
VIM vimentin -0.0336039
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0331738
USP34 ubiquitin specific peptidase 34 -0.0324143
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0321476
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0304605
PRKCA protein kinase C, alpha -0.0293443
SRRM2 serine/arginine repetitive matrix 2 -0.0256375
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0252999
RPLP1 ribosomal protein, large, P1 -0.025038
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0246698
ENO1 enolase 1, (alpha) -0.0240455
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0223545
HELZ helicase with zinc finger -0.0214003
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0189349
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0184567
MARCHF6 membrane associated ring-CH-type finger 6 -0.01709
WNK1 WNK lysine deficient protein kinase 1 -0.0170673
PDE8A phosphodiesterase 8A -0.0164964
ZFAND3 zinc finger, AN1-type domain 3 -0.0140822
PDE10A phosphodiesterase 10A -0.012876
FMNL2 formin-like 2 -0.0128615
MATR3 matrin 3 -0.0126937
SBF2 SET binding factor 2 -0.0119511
NBAS neuroblastoma amplified sequence -0.0106021
RORA RAR-related orphan receptor A -0.0105496
GARS1 glycyl-tRNA synthetase 1 -0.0102788
RBM39 RNA binding motif protein 39 -0.00883763
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.00866222
RUNX1 runt-related transcription factor 1 -0.00857926
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00854431
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00842339
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00701045
SMYD3 SET and MYND domain containing 3 -0.00688703