(S)-Crizotinib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.13679
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0899104
PEG10 paternally expressed 10 0.0513196
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0477493
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0464284
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0441843
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0438353
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0435742
ZNF292 zinc finger protein 292 0.0422557
ZEB2 zinc finger E-box binding homeobox 2 0.0411892
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0395867
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.03937
FNDC3B fibronectin type III domain containing 3B 0.0389497
CLTC clathrin, heavy chain (Hc) 0.0361099
TSC22D2 TSC22 domain family, member 2 0.0359252
SHROOM3 shroom family member 3 0.0339772
METAP2 methionyl aminopeptidase 2 0.0336916
WDR43 WD repeat domain 43 0.0334011
CDC73 cell division cycle 73 0.0333774
TRPS1 trichorhinophalangeal syndrome I 0.0320181
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0310248
ADAM9 ADAM metallopeptidase domain 9 0.030445
TCEA1 transcription elongation factor A (SII), 1 0.0301144
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0297835
MATR3 matrin 3 0.0296077
COL5A2 collagen, type V, alpha 2 0.0287805
NCKAP1 NCK-associated protein 1 0.0284956
CENPF centromere protein F, 350/400kDa 0.0283378
ANXA5 annexin A5 0.0281264
PDS5B PDS5 cohesin associated factor B 0.0277774
NTM neurotrimin 0.0276317
ZFR zinc finger RNA binding protein 0.0274602
TPM3 tropomyosin 3 0.0274252
ECT2 epithelial cell transforming 2 0.0273568
ANXA1 annexin A1 0.0262967
PDGFC platelet derived growth factor C 0.0262908
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0259791
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0255796
THBS1 thrombospondin 1 0.0251134
TMSB4X thymosin beta 4, X-linked 0.0246556
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0243969
NAMPT nicotinamide phosphoribosyltransferase 0.0242218
RAD23B RAD23 homolog B (S. cerevisiae) 0.0239203
NUP58 nucleoporin 58 0.023908
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0237575
IPO7 importin 7 0.0235005
ZNF608 zinc finger protein 608 0.0228891
PUM1 pumilio RNA-binding family member 1 0.0227142
PCBP2 poly(rC) binding protein 2 0.0226134
CALCR calcitonin receptor 0.0224802
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0223479
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0222227
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0219909
CCN2 cellular communication network factor 2 0.0218969
MTF2 metal response element binding transcription factor 2 0.0217783
CFL2 cofilin 2 (muscle) 0.0217608
EVI5 ecotropic viral integration site 5 0.021614
PRPF8 pre-mRNA processing factor 8 0.0215687
U2SURP U2 snRNP-associated SURP domain containing 0.0214953
POTEF POTE ankyrin domain family, member F 0.0213554
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0212271
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0211413
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0210091
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0205833
PGAP1 post-GPI attachment to proteins 1 0.0205505
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0202206
XPO1 exportin 1 0.0200977
COL11A1 collagen, type XI, alpha 1 0.0196223
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.019592
BZW1 basic leucine zipper and W2 domains 1 0.0195875
BCLAF1 BCL2-associated transcription factor 1 0.0195483
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0195414
RAI1 retinoic acid induced 1 0.0193637
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0193608
RAD21 RAD21 homolog (S. pombe) 0.0193027
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.019199
TRIM33 tripartite motif containing 33 0.0191476
GPC4 glypican 4 0.0190878
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.019023
FXR1 fragile X mental retardation, autosomal homolog 1 0.0187889
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0184271
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0183276
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.018292
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.018217
YBX1 Y box binding protein 1 0.0180714
FUBP1 far upstream element (FUSE) binding protein 1 0.0178493
USP3 ubiquitin specific peptidase 3 0.0178356
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0178272
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.017792
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.017702
TWSG1 twisted gastrulation BMP signaling modulator 1 0.0177012
PLS3 plastin 3 0.0176863
TP53BP2 tumor protein p53 binding protein 2 0.017306
SRP54 signal recognition particle 54kDa 0.0172313
HMGN2 high mobility group nucleosomal binding domain 2 0.0172309
BLTP1 bridge-like lipid transfer protein family member 1 0.0171575
OLA1 Obg-like ATPase 1 0.0171156
NOP58 NOP58 ribonucleoprotein 0.0169408
ZNF326 zinc finger protein 326 0.016939
TPX2 TPX2, microtubule-associated 0.01693

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.188544
PTMA prothymosin, alpha -0.182303
VIM vimentin -0.148366
RPS16 ribosomal protein S16 -0.140604
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130251
RPS8 ribosomal protein S8 -0.102253
RPL35A ribosomal protein L35a -0.0996282
TPT1 tumor protein, translationally-controlled 1 -0.0935658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0869718
RPLP1 ribosomal protein, large, P1 -0.0759554
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0746872
RPS6 ribosomal protein S6 -0.0738838
WSB1 WD repeat and SOCS box containing 1 -0.0734202
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0717539
RPS27A ribosomal protein S27a -0.0705693
RPL31 ribosomal protein L31 -0.0664702
RPL37 ribosomal protein L37 -0.0651885
B2M beta-2-microglobulin -0.060539
RPL37A ribosomal protein L37a -0.0579268
ISG15 ISG15 ubiquitin-like modifier -0.0564955
RPS19 ribosomal protein S19 -0.0555275
FTL ferritin, light polypeptide -0.0552239
RPS25 ribosomal protein S25 -0.0487555
ACTG1 actin gamma 1 -0.0485106
RPS13 ribosomal protein S13 -0.0478416
RPS12 ribosomal protein S12 -0.0476968
PHIP pleckstrin homology domain interacting protein -0.0472885
RPL9 ribosomal protein L9 -0.0461423
RPL19 ribosomal protein L19 -0.0459052
RPL26 ribosomal protein L26 -0.0451348
RPS24 ribosomal protein S24 -0.0444049
RPL11 ribosomal protein L11 -0.0441148
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0438363
RPL34 ribosomal protein L34 -0.042864
RPS21 ribosomal protein S21 -0.0428482
COL3A1 collagen, type III, alpha 1 -0.0424241
RPL36A ribosomal protein L36a -0.0416656
CADM2 cell adhesion molecule 2 -0.0414151
LOC102724023 ES1 protein homolog, mitochondrial -0.0412973
RPL5 ribosomal protein L5 -0.0411197
RPLP2 ribosomal protein, large, P2 -0.0405344
RPS3 ribosomal protein S3 -0.0397509
RPS29 ribosomal protein S29 -0.0392506
RPL28 ribosomal protein L28 -0.0392319
ANKRD12 ankyrin repeat domain 12 -0.0385939
RPL23 ribosomal protein L23 -0.0373097
ANKRD33B ankyrin repeat domain 33B -0.0371161
COL1A2 collagen, type I, alpha 2 -0.0369984
RPS10 ribosomal protein S10 -0.0365569
PCLO piccolo presynaptic cytomatrix protein -0.0364425
CNRIP1 cannabinoid receptor interacting protein 1 -0.0359847
MT2A metallothionein 2A -0.0355346
S100A10 S100 calcium binding protein A10 -0.0341933
AKAP12 A kinase (PRKA) anchor protein 12 -0.0340558
RPL12 ribosomal protein L12 -0.0339422
APOE apolipoprotein E -0.0339277
GNAS GNAS complex locus -0.0338198
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0336734
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0335892
MDK midkine (neurite growth-promoting factor 2) -0.0330243
PGK1 phosphoglycerate kinase 1 -0.032869
RPS27 ribosomal protein S27 -0.0327027
ENO1 enolase 1, (alpha) -0.0321964
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0321231
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0318543
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.031788
RPL7A ribosomal protein L7a -0.0317127
EIF1 eukaryotic translation initiation factor 1 -0.0310742
TBCA tubulin folding cofactor A -0.0309147
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0307477
INTS6 integrator complex subunit 6 -0.0288156
PKM pyruvate kinase, muscle -0.0287886
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0287243
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0283917
FAM177A1 family with sequence similarity 177, member A1 -0.0282708
MRPS6 mitochondrial ribosomal protein S6 -0.0282014
RPS11 ribosomal protein S11 -0.0280158
SRRM2 serine/arginine repetitive matrix 2 -0.0274389
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.027399
RPS17 ribosomal protein S17 -0.0272694
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0270213
UBC ubiquitin C -0.0269115
PCDH9 protocadherin 9 -0.0268785
RPL38 ribosomal protein L38 -0.0263899
RPS15 ribosomal protein S15 -0.0261486
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0260273
ATF4 activating transcription factor 4 -0.0259503
SERF2 small EDRK-rich factor 2 -0.0259372
DSCAM Down syndrome cell adhesion molecule -0.0255938
HSPB1 heat shock 27kDa protein 1 -0.0255461
RPL30 ribosomal protein L30 -0.0250914
RPS23 ribosomal protein S23 -0.0248435
RPL8 ribosomal protein L8 -0.0248023
RPL32 ribosomal protein L32 -0.0247822
CALR calreticulin -0.0247591
SPAG9 sperm associated antigen 9 -0.0246426
S100A9 S100 calcium binding protein A9 -0.024503
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0244625
NCOR2 nuclear receptor corepressor 2 -0.0242881
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0241478