(S)-Crizotinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.186599
NAMPT nicotinamide phosphoribosyltransferase 0.115517
VEGFA vascular endothelial growth factor A 0.0703709
MSN moesin 0.0575441
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0562581
INSIG1 insulin induced gene 1 0.053612
ELOVL5 ELOVL fatty acid elongase 5 0.0445351
PCBP2 poly(rC) binding protein 2 0.038477
MYH9 myosin, heavy chain 9, non-muscle 0.0375579
RPS12 ribosomal protein S12 0.0364785
LDLR low density lipoprotein receptor 0.0357593
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0351564
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0341092
AKAP12 A kinase (PRKA) anchor protein 12 0.0301544
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0286316
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0281396
NAV2 neuron navigator 2 0.0280328
SREBF2 sterol regulatory element binding transcription factor 2 0.0280305
FNDC3B fibronectin type III domain containing 3B 0.0277503
MSMO1 methylsterol monooxygenase 1 0.0277341
KDM6A lysine (K)-specific demethylase 6A 0.0275266
ATP13A3 ATPase type 13A3 0.0274977
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0272686
SNX9 sorting nexin 9 0.0266027
LCOR ligand dependent nuclear receptor corepressor 0.025446
NOTCH2 notch 2 0.0227582
ZMIZ1 zinc finger, MIZ-type containing 1 0.0225976
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0221055
PPARD peroxisome proliferator-activated receptor delta 0.0220706
SFTPA2 surfactant protein A2 0.0220232
FDPS farnesyl diphosphate synthase 0.0216376
ZNF451 zinc finger protein 451 0.0214437
USP9X ubiquitin specific peptidase 9, X-linked 0.0211782
AFDN afadin, adherens junction formation factor 0.0209401
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0206131
TRIO trio Rho guanine nucleotide exchange factor 0.0205577
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0200859
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0199869
MYOF myoferlin 0.0199572
TGM2 transglutaminase 2 0.0197615
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0194779
CRY1 cryptochrome circadian clock 1 0.0194332
CD46 CD46 molecule, complement regulatory protein 0.0192724
POTEF POTE ankyrin domain family, member F 0.0191367
MAPK8 mitogen-activated protein kinase 8 0.0188826
RPS17 ribosomal protein S17 0.0187768
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0185124
USP37 ubiquitin specific peptidase 37 0.0183854
DNHD1 dynein heavy chain domain 1 0.0181562
SCAF8 SR-related CTD-associated factor 8 0.0180581
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.017587
ERBIN erbb2 interacting protein 0.01756
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0174728
IL6ST interleukin 6 signal transducer 0.0174188
TNIP1 TNFAIP3 interacting protein 1 0.0173037
RASEF RAS and EF-hand domain containing 0.0169525
BIRC6 baculoviral IAP repeat containing 6 0.0169484
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0167499
SMAD3 SMAD family member 3 0.0166699
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0166549
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0163149
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0162921
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0161983
UVRAG UV radiation resistance associated 0.0158658
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0157955
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0157447
RAB6A RAB6A, member RAS oncogene family 0.0155984
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0153108
EPB41 erythrocyte membrane protein band 4.1 0.0152821
NGLY1 N-glycanase 1 0.0152599
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0152179
FLOT1 flotillin 1 0.0151778
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0150834
CERT1 ceramide transporter 1 0.0150458
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0148094
WDR43 WD repeat domain 43 0.0147252
USP12 ubiquitin specific peptidase 12 0.0144109
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0143024
MAST4 microtubule associated serine/threonine kinase family member 4 0.0141464
NRIP1 nuclear receptor interacting protein 1 0.0139746
ANXA5 annexin A5 0.0138733
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0137137
DMTF1 cyclin D binding myb-like transcription factor 1 0.0136319
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0135449
DSCAM Down syndrome cell adhesion molecule 0.013509
ANKRD36 ankyrin repeat domain 36 0.0134877
SQLE squalene epoxidase 0.0133539
PANK3 pantothenate kinase 3 0.0132631
UBE3A ubiquitin protein ligase E3A 0.0131951
ARFGEF3 ARFGEF family member 3 0.0131096
ACACA acetyl-CoA carboxylase alpha 0.0130912
AMPD3 adenosine monophosphate deaminase 3 0.0130837
CDK19 cyclin-dependent kinase 19 0.0130609
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0130478
CCBE1 collagen and calcium binding EGF domains 1 0.0129237
MATR3 matrin 3 0.0129207
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0126241
DOCK5 dedicator of cytokinesis 5 0.0125115
PLPP3 phospholipid phosphatase 3 0.0124975
CKAP5 cytoskeleton associated protein 5 0.0124298

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.30982
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.270838
HLA-B major histocompatibility complex, class I, B -0.16903
MARCKS myristoylated alanine-rich protein kinase C substrate -0.148071
IER3 immediate early response 3 -0.125397
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124262
FN1 fibronectin 1 -0.114514
TPT1 tumor protein, translationally-controlled 1 -0.113422
PGK1 phosphoglycerate kinase 1 -0.111235
FTL ferritin, light polypeptide -0.10738
TMSB10 thymosin beta 10 -0.0977289
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0961263
PTMA prothymosin, alpha -0.0898264
CANX calnexin -0.0782031
IGFBP3 insulin-like growth factor binding protein 3 -0.068266
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0634161
ANXA2 annexin A2 -0.0617124
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0579364
EXT1 exostosin glycosyltransferase 1 -0.0577449
ENO1 enolase 1, (alpha) -0.0561547
RPS24 ribosomal protein S24 -0.055959
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0558054
GLIS3 GLIS family zinc finger 3 -0.0543655
ACTG1 actin gamma 1 -0.0540506
HLA-E major histocompatibility complex, class I, E -0.0525772
KDM3A lysine (K)-specific demethylase 3A -0.052154
GPC6 glypican 6 -0.0518081
TXNIP thioredoxin interacting protein -0.0506238
RPL35A ribosomal protein L35a -0.0498078
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0495777
IFI16 interferon, gamma-inducible protein 16 -0.0491596
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0491139
VCL vinculin -0.0486162
COL1A1 collagen, type I, alpha 1 -0.0480178
CALR calreticulin -0.0478639
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0474091
LDHA lactate dehydrogenase A -0.0474016
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0458622
GNAS GNAS complex locus -0.0458576
IFITM3 interferon induced transmembrane protein 3 -0.0442559
UBC ubiquitin C -0.0441599
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0440218
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0439362
RPS6 ribosomal protein S6 -0.0435936
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0433584
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0429068
MKI67 marker of proliferation Ki-67 -0.0419069
PLIN2 perilipin 2 -0.0415455
AHNAK AHNAK nucleoprotein -0.0413141
WSB1 WD repeat and SOCS box containing 1 -0.0408342
RBM39 RNA binding motif protein 39 -0.0398666
TMSB4X thymosin beta 4, X-linked -0.0395708
RPL32 ribosomal protein L32 -0.0394413
ZMYND8 zinc finger, MYND-type containing 8 -0.039394
MT2A metallothionein 2A -0.0388194
LOC112694756 uncharaterized LOC112694756 -0.0386906
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0384766
RPL26 ribosomal protein L26 -0.0383535
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0379313
SFRP1 secreted frizzled-related protein 1 -0.0373714
RPS8 ribosomal protein S8 -0.0369964
DEK DEK proto-oncogene -0.0362997
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0362623
TUBB tubulin, beta class I -0.035026
VCAN versican -0.034692
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0343239
TPM4 tropomyosin 4 -0.0337904
ZNFX1 zinc finger, NFX1-type containing 1 -0.0337643
CTSD cathepsin D -0.0336401
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0333332
CTSB cathepsin B -0.0333154
VDAC1 voltage-dependent anion channel 1 -0.032868
TMEM123 transmembrane protein 123 -0.0327676
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0326483
RNF213 ring finger protein 213 -0.0319914
CLIC4 chloride intracellular channel 4 -0.0319164
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0316826
NAV1 neuron navigator 1 -0.0316701
SQSTM1 sequestosome 1 -0.0310106
RPS13 ribosomal protein S13 -0.030161
RPLP1 ribosomal protein, large, P1 -0.0299046
IFITM1 interferon induced transmembrane protein 1 -0.0298834
LOC102724023 ES1 protein homolog, mitochondrial -0.0296516
MORF4L2 mortality factor 4 like 2 -0.029566
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0295375
S100A9 S100 calcium binding protein A9 -0.029531
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0294003
IFI6 interferon, alpha-inducible protein 6 -0.0293995
RPL34 ribosomal protein L34 -0.0285062
KDM5B lysine (K)-specific demethylase 5B -0.0284652
PDIA3 protein disulfide isomerase family A, member 3 -0.0283471
JUN jun proto-oncogene -0.028209
BASP1 brain abundant, membrane attached signal protein 1 -0.0281153
NAP1L1 nucleosome assembly protein 1-like 1 -0.0279467
CENPF centromere protein F, 350/400kDa -0.027664
LPP LIM domain containing preferred translocation partner in lipoma -0.0276211
NCOA7 nuclear receptor coactivator 7 -0.0272774
JMJD1C jumonji domain containing 1C -0.0271727
FAM162A family with sequence similarity 162, member A -0.027098
BPTF bromodomain PHD finger transcription factor -0.0270422