| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | (S)-Crizotinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the (S)-Crizotinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.098655 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0485653 |
| ARRDC3 | arrestin domain containing 3 | 0.0449025 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0435054 |
| RTN4 | reticulon 4 | 0.0432988 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0414188 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0339996 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0339545 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.033795 |
| FAT1 | FAT atypical cadherin 1 | 0.0336423 |
| TXNRD1 | thioredoxin reductase 1 | 0.0330844 |
| CCDC14 | coiled-coil domain containing 14 | 0.031128 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0304865 |
| MEF2A | myocyte enhancer factor 2A | 0.0291843 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0285912 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0285645 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0281969 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0278976 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0276611 |
| MATR3 | matrin 3 | 0.0274745 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0270938 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0263661 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0263229 |
| AHR | aryl hydrocarbon receptor | 0.0262578 |
| NRG1 | neuregulin 1 | 0.0261287 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0257066 |
| LUZP1 | leucine zipper protein 1 | 0.0256312 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0254751 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0248104 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.024803 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0247829 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0247102 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0245615 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0242711 |
| USP24 | ubiquitin specific peptidase 24 | 0.0242157 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0239773 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0235457 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.023522 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0229646 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.0227582 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0225934 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0225808 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0220987 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0220894 |
| RPL23 | ribosomal protein L23 | 0.0219702 |
| RPS6 | ribosomal protein S6 | 0.0215571 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0213544 |
| CD44 | CD44 molecule (Indian blood group) | 0.0212952 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0210876 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0209874 |
| C1D | C1D nuclear receptor corepressor | 0.0209244 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0208361 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0207883 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0206959 |
| ASPH | aspartate beta-hydroxylase | 0.0205585 |
| SYT1 | synaptotagmin I | 0.0204714 |
| CCNL1 | cyclin L1 | 0.0204228 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0203349 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0202789 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0201399 |
| HDAC9 | histone deacetylase 9 | 0.0201395 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0201131 |
| ATP13A3 | ATPase type 13A3 | 0.0200816 |
| DENND5A | DENN/MADD domain containing 5A | 0.0199029 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0198821 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0196631 |
| YBX3 | Y box binding protein 3 | 0.019623 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0192652 |
| USP3 | ubiquitin specific peptidase 3 | 0.0192608 |
| TENM2 | teneurin transmembrane protein 2 | 0.0190558 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0190097 |
| PDE7A | phosphodiesterase 7A | 0.0189548 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0188932 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 0.0187482 |
| USP37 | ubiquitin specific peptidase 37 | 0.0186629 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0186593 |
| IL1R1 | interleukin 1 receptor, type I | 0.0185866 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0185459 |
| CCDC6 | coiled-coil domain containing 6 | 0.0183163 |
| TMEM167A | transmembrane protein 167A | 0.0182817 |
| NBEA | neurobeachin | 0.0181521 |
| FADS2 | fatty acid desaturase 2 | 0.0181447 |
| TTBK2 | tau tubulin kinase 2 | 0.0179579 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.0179459 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0179302 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.017865 |
| PHIP | pleckstrin homology domain interacting protein | 0.0178582 |
| JAG1 | jagged 1 | 0.0177929 |
| AZIN1 | antizyme inhibitor 1 | 0.0177353 |
| GPHN | gephyrin | 0.0176841 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.017594 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0175927 |
| SP140L | SP140 nuclear body protein-like | 0.017577 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0174481 |
| CTSA | cathepsin A | 0.0174213 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0173766 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.0172814 |
| AFDN | afadin, adherens junction formation factor | 0.0171865 |
| LEPROT | leptin receptor overlapping transcript | 0.0171311 |
| GPC6 | glypican 6 | 0.0170993 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.259188 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.250355 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.188815 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.182063 |
| FN1 | fibronectin 1 | -0.168234 |
| VIM | vimentin | -0.163923 |
| HLA-B | major histocompatibility complex, class I, B | -0.119839 |
| TMSB10 | thymosin beta 10 | -0.119229 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.10003 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0981345 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0778084 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0760279 |
| STC1 | stanniocalcin 1 | -0.0756915 |
| CDH13 | cadherin 13 | -0.0750205 |
| AHNAK | AHNAK nucleoprotein | -0.0748064 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0709297 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0702782 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0634997 |
| HMGA2 | high mobility group AT-hook 2 | -0.0561633 |
| CANX | calnexin | -0.0559638 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0559362 |
| MT2A | metallothionein 2A | -0.054691 |
| VCL | vinculin | -0.0546184 |
| SDC4 | syndecan 4 | -0.0542897 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0513847 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0509349 |
| CALU | calumenin | -0.0502779 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0490744 |
| LOX | lysyl oxidase | -0.047583 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0454446 |
| PRSS23 | protease, serine, 23 | -0.0452991 |
| EGFR | epidermal growth factor receptor | -0.0451846 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0451387 |
| HLA-C | major histocompatibility complex, class I, C | -0.0445165 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0444978 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0429941 |
| ENO1 | enolase 1, (alpha) | -0.0428451 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0425117 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0407433 |
| CALR | calreticulin | -0.0406553 |
| COL5A1 | collagen, type V, alpha 1 | -0.0406548 |
| B2M | beta-2-microglobulin | -0.040612 |
| ACTG1 | actin gamma 1 | -0.0400933 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0399653 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0393174 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0386827 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0386756 |
| COL1A1 | collagen, type I, alpha 1 | -0.0384138 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0380009 |
| CALD1 | caldesmon 1 | -0.0377638 |
| HIP1 | huntingtin interacting protein 1 | -0.0375361 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0370803 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0370796 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0369465 |
| TPM4 | tropomyosin 4 | -0.0361079 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0356054 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0348136 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.034522 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0340595 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0333937 |
| EXOC4 | exocyst complex component 4 | -0.0332083 |
| INTS6 | integrator complex subunit 6 | -0.0327624 |
| HM13 | histocompatibility (minor) 13 | -0.0322906 |
| SEC24D | SEC24 family member D | -0.0321656 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0319025 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0317996 |
| TNS3 | tensin 3 | -0.0315686 |
| NRXN3 | neurexin 3 | -0.03136 |
| KAZN | kazrin, periplakin interacting protein | -0.0312544 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0310639 |
| MAP1B | microtubule-associated protein 1B | -0.0307083 |
| PTGES2 | prostaglandin E synthase 2 | -0.030409 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0298652 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.029769 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0293412 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0289439 |
| NAV1 | neuron navigator 1 | -0.0286591 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0285128 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0279659 |
| NDRG1 | N-myc downstream regulated 1 | -0.0276316 |
| PGK1 | phosphoglycerate kinase 1 | -0.0276071 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0275599 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0272591 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0271233 |
| HDLBP | high density lipoprotein binding protein | -0.0269664 |
| GOLGA4 | golgin A4 | -0.0265808 |
| RAD51B | RAD51 paralog B | -0.0262834 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0259398 |
| MYO10 | myosin X | -0.0258828 |
| GPR173 | G protein-coupled receptor 173 | -0.0258781 |
| GLIS3 | GLIS family zinc finger 3 | -0.0257606 |
| UBC | ubiquitin C | -0.0256374 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0251482 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0250106 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0248994 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.024531 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.0242551 |
| LOXL2 | lysyl oxidase-like 2 | -0.0241 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0239726 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0239318 |
