| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/969472 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in (S)-Zopiclone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBXW8 | F-box and WD repeat domain containing 8 | 0.52 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | 0.52 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | 0.5 |
| CAVIN2 | caveolae associated protein 2 | 0.46 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | 0.46 |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.46 |
| AXIN2 | axin 2 | 0.45 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.4 |
| LYST | lysosomal trafficking regulator | 0.4 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.39 |
| NLRC3 | NLR family, CARD domain containing 3 | 0.39 |
| CLCN7 | chloride channel, voltage-sensitive 7 | 0.39 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.37 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.34 |
| REXO5 | RNA exonuclease 5 | 0.33 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.33 |
| KIAA1324L | KIAA1324-like | 0.32 |
| RPL30 | ribosomal protein L30 | 0.32 |
| RBM47 | RNA binding motif protein 47 | 0.32 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.31 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.31 |
| DUOX1 | dual oxidase 1 | 0.31 |
| TPM4 | tropomyosin 4 | 0.31 |
| R3HCC1L | R3H domain and coiled-coil containing 1-like | 0.31 |
| CDC25B | cell division cycle 25B | 0.29 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.29 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.28 |
| ZNF584 | zinc finger protein 584 | 0.28 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | 0.27 |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | 0.27 |
| RFLNB | refilin B | 0.27 |
| RPLP1 | ribosomal protein, large, P1 | 0.27 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.26 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.26 |
| BOK | BCL2-related ovarian killer | 0.26 |
| ACTBL2 | actin, beta-like 2 | 0.26 |
| TRAPPC2L | trafficking protein particle complex 2-like | 0.26 |
| TTC31 | tetratricopeptide repeat domain 31 | 0.26 |
| MYO9A | myosin IXA | 0.25 |
| FBXO44 | F-box protein 44 | 0.25 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.25 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 0.25 |
| C9ORF40 | chromosome 9 open reading frame 40 | 0.25 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.25 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | 0.25 |
| ATXN7L2 | ataxin 7-like 2 | 0.24 |
| ZNF337 | zinc finger protein 337 | 0.24 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.24 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.24 |
| NRM | nurim (nuclear envelope membrane protein) | 0.24 |
| RNF8 | ring finger protein 8, E3 ubiquitin protein ligase | 0.24 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.24 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.23 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | 0.23 |
| RPL37A | ribosomal protein L37a | 0.23 |
| PCGF6 | polycomb group ring finger 6 | 0.23 |
| NKAPD1 | NKAP domain containing 1 | 0.23 |
| DUSP5 | dual specificity phosphatase 5 | 0.22 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.22 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.22 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.22 |
| ELOC | elongin C | 0.22 |
| ZFP1 | ZFP1 zinc finger protein | 0.22 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.22 |
| COPRS | coordinator of PRMT5, differentiation stimulator | 0.22 |
| TAPT1 | transmembrane anterior posterior transformation 1 | 0.22 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.21 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.21 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.21 |
| E2F4 | E2F transcription factor 4, p107/p130-binding | 0.21 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | 0.21 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | 0.21 |
| RPLP2 | ribosomal protein, large, P2 | 0.21 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | 0.21 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.21 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | 0.21 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.21 |
| SP100 | SP100 nuclear antigen | 0.21 |
| ZCRB1 | zinc finger CCHC-type and RNA binding motif 1 | 0.2 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.2 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.2 |
| ACTN4 | actinin, alpha 4 | 0.2 |
| RPL26L1 | ribosomal protein L26-like 1 | 0.2 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.2 |
| DNAH9 | dynein, axonemal, heavy chain 9 | 0.2 |
| GLRX2 | glutaredoxin 2 | 0.2 |
| BANF1 | barrier to autointegration factor 1 | 0.2 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.2 |
| EYS | eyes shut homolog (Drosophila) | 0.2 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.2 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.2 |
| DDTL | D-dopachrome tautomerase-like | 0.2 |
| RELL1 | RELT-like 1 | 0.2 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.2 |
| AZIN1 | antizyme inhibitor 1 | 0.19 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.19 |
| LRRK2 | leucine-rich repeat kinase 2 | 0.19 |
| MIEN1 | migration and invasion enhancer 1 | 0.19 |
| MFSD6 | major facilitator superfamily domain containing 6 | 0.19 |
| FPGS | folylpolyglutamate synthase | 0.19 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | -1.33 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -1.16 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -1.05 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.88 |
| DMD | dystrophin | -0.83 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | -0.68 |
| CCN3 | cellular communication network factor 3 | -0.62 |
| TSPAN3 | tetraspanin 3 | -0.61 |
| RNF13 | ring finger protein 13 | -0.61 |
| CKM | creatine kinase, muscle | -0.58 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.57 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.57 |
| DST | dystonin | -0.56 |
| GRAMD2B | GRAM domain containing 2B | -0.5 |
| NRP1 | neuropilin 1 | -0.49 |
| R3HDM2 | R3H domain containing 2 | -0.47 |
| MYL9 | myosin, light chain 9, regulatory | -0.47 |
| RPL26 | ribosomal protein L26 | -0.45 |
| ZC3H10 | zinc finger CCCH-type containing 10 | -0.45 |
| RNF166 | ring finger protein 166 | -0.45 |
| CD63 | CD63 molecule | -0.44 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.41 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.41 |
| IL6ST | interleukin 6 signal transducer | -0.4 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.39 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.39 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.39 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.37 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.37 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.37 |
| FAM110C | family with sequence similarity 110, member C | -0.37 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.37 |
| EFCAB7 | EF-hand calcium binding domain 7 | -0.36 |
| HPCAL4 | hippocalcin like 4 | -0.35 |
| PYGM | phosphorylase, glycogen, muscle | -0.35 |
| CA8 | carbonic anhydrase VIII | -0.35 |
| TMEM159 | transmembrane protein 159 | -0.35 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.35 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.34 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.34 |
| TUBAL3 | tubulin, alpha-like 3 | -0.34 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | -0.34 |
| LRRC45 | leucine rich repeat containing 45 | -0.34 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.33 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.33 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.33 |
| TYRO3 | TYRO3 protein tyrosine kinase | -0.32 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.32 |
| ZNF367 | zinc finger protein 367 | -0.32 |
| NRXN3 | neurexin 3 | -0.32 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.32 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.31 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.31 |
| RNF19B | ring finger protein 19B | -0.31 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.31 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.3 |
| RBM42 | RNA binding motif protein 42 | -0.3 |
| APOB | apolipoprotein B | -0.3 |
| ADCK5 | aarF domain containing kinase 5 | -0.3 |
| WDR20 | WD repeat domain 20 | -0.3 |
| PDCD5 | programmed cell death 5 | -0.3 |
| PXN | paxillin | -0.3 |
| TMEM51 | transmembrane protein 51 | -0.3 |
| STON2 | stonin 2 | -0.29 |
| TEC | tec protein tyrosine kinase | -0.29 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.29 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | -0.29 |
| ZNF581 | zinc finger protein 581 | -0.29 |
| ZNF776 | zinc finger protein 776 | -0.29 |
| JAGN1 | jagunal homolog 1 (Drosophila) | -0.28 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.28 |
| MYBPC1 | myosin binding protein C, slow type | -0.28 |
| JRKL | JRK-like | -0.28 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.28 |
| HFE | hemochromatosis | -0.28 |
| POLH | polymerase (DNA directed), eta | -0.28 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.27 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.27 |
| ZFPM1 | zinc finger protein, FOG family member 1 | -0.27 |
| COBL | cordon-bleu WH2 repeat protein | -0.27 |
| PAH | phenylalanine hydroxylase | -0.27 |
| IL10RB | interleukin 10 receptor, beta | -0.27 |
| RNF149 | ring finger protein 149 | -0.26 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | -0.26 |
| CBR1 | carbonyl reductase 1 | -0.26 |
| PRMT2IP | PRMT2 interacting protein | -0.26 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.26 |
| MED30 | mediator complex subunit 30 | -0.26 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.26 |
| QPCTL | glutaminyl-peptide cyclotransferase-like | -0.26 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.26 |
| C2CD4C | C2 calcium-dependent domain containing 4C | -0.26 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | -0.26 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.25 |
| SAMD8 | sterile alpha motif domain containing 8 | -0.25 |
| OSCP1 | organic solute carrier partner 1 | -0.25 |
| MEGF8 | multiple EGF-like-domains 8 | -0.25 |
| SCAND1 | SCAN domain containing 1 | -0.25 |
| CAV2 | caveolin 2 | -0.25 |
