| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25085173 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in [Pyr1]-Apelin-13 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CARD8 | caspase recruitment domain family, member 8 | 0.78 |
| PIP | prolactin-induced protein | 0.66 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.61 |
| CDK10 | cyclin-dependent kinase 10 | 0.49 |
| RMI2 | RecQ mediated genome instability 2 | 0.48 |
| MIDN | midnolin | 0.45 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.44 |
| MANEAL | mannosidase, endo-alpha-like | 0.43 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.43 |
| MSX1 | msh homeobox 1 | 0.42 |
| ODC1 | ornithine decarboxylase 1 | 0.42 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.41 |
| GPN2 | GPN-loop GTPase 2 | 0.4 |
| SUSD1 | sushi domain containing 1 | 0.4 |
| HOXA9 | homeobox A9 | 0.39 |
| RCAN3 | RCAN family member 3 | 0.37 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | 0.36 |
| SCARA3 | scavenger receptor class A, member 3 | 0.36 |
| AZIN1 | antizyme inhibitor 1 | 0.35 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.35 |
| RARG | retinoic acid receptor, gamma | 0.34 |
| CCDC57 | coiled-coil domain containing 57 | 0.34 |
| SEMA4F | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F | 0.33 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.33 |
| DXO | decapping exoribonuclease | 0.33 |
| KLHDC8B | kelch domain containing 8B | 0.33 |
| ZIC5 | Zic family member 5 | 0.32 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.32 |
| MCPH1 | microcephalin 1 | 0.32 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.32 |
| NADK | NAD kinase | 0.32 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.31 |
| ZNF778 | zinc finger protein 778 | 0.31 |
| DEPDC7 | DEP domain containing 7 | 0.31 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | 0.31 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.3 |
| ALKBH6 | alkB, alkylation repair homolog 6 (E. coli) | 0.3 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.3 |
| SLC16A10 | solute carrier family 16 (aromatic amino acid transporter), member 10 | 0.29 |
| DEDD | death effector domain containing | 0.29 |
| CADPS | Ca++-dependent secretion activator | 0.29 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.29 |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.29 |
| SYTL3 | synaptotagmin-like 3 | 0.29 |
| FBXO41 | F-box protein 41 | 0.29 |
| TMEM62 | transmembrane protein 62 | 0.29 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.29 |
| SATB1 | SATB homeobox 1 | 0.29 |
| RFLNB | refilin B | 0.28 |
| MTBP | MDM2 binding protein | 0.28 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.28 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | 0.28 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.28 |
| RGN | regucalcin | 0.28 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | 0.28 |
| TRNP1 | TMF1-regulated nuclear protein 1 | 0.28 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.28 |
| TMEM9 | transmembrane protein 9 | 0.27 |
| CCNF | cyclin F | 0.27 |
| FBXO44 | F-box protein 44 | 0.27 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.27 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | 0.27 |
| ZNF124 | zinc finger protein 124 | 0.27 |
| ARHGEF26 | Rho guanine nucleotide exchange factor (GEF) 26 | 0.26 |
| HINT3 | histidine triad nucleotide binding protein 3 | 0.26 |
| KLF13 | Kruppel-like factor 13 | 0.26 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.26 |
| TAOK2 | TAO kinase 2 | 0.26 |
| POLQ | polymerase (DNA directed), theta | 0.26 |
| CALU | calumenin | 0.26 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 0.26 |
| SNAI1 | snail family zinc finger 1 | 0.26 |
| YAF2 | YY1 associated factor 2 | 0.26 |
| RIC1 | RAB6A GEF complex partner 1 | 0.26 |
| ZNF696 | zinc finger protein 696 | 0.26 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.25 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.25 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | 0.25 |
| COPRS | coordinator of PRMT5, differentiation stimulator | 0.25 |
| CCNB1 | cyclin B1 | 0.25 |
| GEN1 | GEN1 Holliday junction 5' flap endonuclease | 0.25 |
| RNASEH1 | ribonuclease H1 | 0.25 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.25 |
| ZNF100 | zinc finger protein 100 | 0.25 |
| ZNF669 | zinc finger protein 669 | 0.25 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.25 |
| MIGA2 | mitoguardin 2 | 0.24 |
| GK5 | glycerol kinase 5 (putative) | 0.24 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.24 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.24 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.24 |
| CENPT | centromere protein T | 0.24 |
| COMMD5 | COMM domain containing 5 | 0.24 |
| MAGEF1 | melanoma antigen family F1 | 0.24 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.24 |
| PARD6G | par-6 family cell polarity regulator gamma | 0.24 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.24 |
| LYRM7 | LYR motif containing 7 | 0.24 |
| CDC25B | cell division cycle 25B | 0.24 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN3 | tetraspanin 3 | -0.83 |
| ZNF319 | zinc finger protein 319 | -0.8 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.7 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | -0.67 |
| NRP1 | neuropilin 1 | -0.59 |
| KIAA1107 | KIAA1107 | -0.58 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.58 |
| TBX3 | T-box 3 | -0.54 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.53 |
| ADIRF | adipogenesis regulatory factor | -0.53 |
| C5ORF24 | chromosome 5 open reading frame 24 | -0.51 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.49 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.49 |
| ZNF160 | zinc finger protein 160 | -0.48 |
| HBA1 | hemoglobin, alpha 1 | -0.48 |
| SMIM19 | small integral membrane protein 19 | -0.48 |
| C19ORF25 | chromosome 19 open reading frame 25 | -0.47 |
| CD63 | CD63 molecule | -0.47 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | -0.45 |
| FTL | ferritin, light polypeptide | -0.44 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.44 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | -0.43 |
| FN1 | fibronectin 1 | -0.42 |
| NOTCH3 | notch 3 | -0.41 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.4 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.4 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.4 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.4 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.39 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.39 |
| ZNF16 | zinc finger protein 16 | -0.38 |
| RNF149 | ring finger protein 149 | -0.38 |
| SLC38A1 | solute carrier family 38, member 1 | -0.38 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.38 |
| GDF15 | growth differentiation factor 15 | -0.37 |
| PDE9A | phosphodiesterase 9A | -0.37 |
| METTL25 | methyltransferase like 25 | -0.36 |
| RNF13 | ring finger protein 13 | -0.35 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.35 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.35 |
| QPCTL | glutaminyl-peptide cyclotransferase-like | -0.34 |
| RBM47 | RNA binding motif protein 47 | -0.34 |
| S100A6 | S100 calcium binding protein A6 | -0.34 |
| PLPP3 | phospholipid phosphatase 3 | -0.34 |
| NENF | neudesin neurotrophic factor | -0.34 |
| ZNF624 | zinc finger protein 624 | -0.34 |
| DOCK10 | dedicator of cytokinesis 10 | -0.34 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -0.33 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | -0.33 |
| ADCK5 | aarF domain containing kinase 5 | -0.33 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.32 |
| BCDIN3D | BCDIN3 domain containing | -0.32 |
| NCOA7 | nuclear receptor coactivator 7 | -0.32 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.32 |
| LMBRD1 | LMBR1 domain containing 1 | -0.32 |
| MISP3 | MISP family member 3 | -0.32 |
| TMEM184C | transmembrane protein 184C | -0.32 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.31 |
| TMEM231 | transmembrane protein 231 | -0.31 |
| SPPL2B | signal peptide peptidase like 2B | -0.31 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.31 |
| ZFP90 | ZFP90 zinc finger protein | -0.31 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.3 |
| NIBAN1 | niban apoptosis regulator 1 | -0.3 |
| TMPO | thymopoietin | -0.3 |
| STMN2 | stathmin 2 | -0.3 |
| LRRK2 | leucine-rich repeat kinase 2 | -0.3 |
| S100A14 | S100 calcium binding protein A14 | -0.3 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.3 |
| HM13 | histocompatibility (minor) 13 | -0.29 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.29 |
| CCND3 | cyclin D3 | -0.29 |
| FAM122A | family with sequence similarity 122A | -0.29 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.29 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.29 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | -0.29 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.28 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | -0.28 |
| KIAA0513 | KIAA0513 | -0.28 |
| YBEY | ybeY metallopeptidase (putative) | -0.28 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.28 |
| CBR1 | carbonyl reductase 1 | -0.28 |
| RHBDD1 | rhomboid domain containing 1 | -0.28 |
| PLD3 | phospholipase D family, member 3 | -0.28 |
| TMSB10 | thymosin beta 10 | -0.28 |
| TYMP | thymidine phosphorylase | -0.28 |
| GLRX | glutaredoxin (thioltransferase) | -0.27 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -0.27 |
| MT2A | metallothionein 2A | -0.27 |
| RAB33B | RAB33B, member RAS oncogene family | -0.27 |
| KLK7 | kallikrein-related peptidase 7 | -0.27 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.27 |
| TXN2 | thioredoxin 2 | -0.26 |
| TMEM59 | transmembrane protein 59 | -0.26 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.26 |
| AMOTL1 | angiomotin like 1 | -0.26 |
| STK19 | serine/threonine kinase 19 | -0.26 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | -0.26 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | -0.26 |
