γ-Oryzanol_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.182156
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.121629
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.115743
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0891797
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0837761
DLG1 discs, large homolog 1 (Drosophila) 0.0787833
LOXL2 lysyl oxidase-like 2 0.0602402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0574299
FNDC3B fibronectin type III domain containing 3B 0.0547954
ELL2 elongation factor, RNA polymerase II, 2 0.0514691
NDRG1 N-myc downstream regulated 1 0.0514306
TRIO trio Rho guanine nucleotide exchange factor 0.0508604
UBC ubiquitin C 0.0497229
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0489005
MYADM myeloid-associated differentiation marker 0.0480591
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0479007
IGFBP3 insulin-like growth factor binding protein 3 0.0465348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0435468
FLNB filamin B, beta 0.0427176
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.04217
PLAT plasminogen activator, tissue 0.0421176
B2M beta-2-microglobulin 0.0413764
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0374354
VEGFA vascular endothelial growth factor A 0.0360967
OGA O-GlcNAcase 0.0347449
CALR calreticulin 0.0344709
OPTN optineurin 0.0324264
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0323056
FBN1 fibrillin 1 0.0320461
STC1 stanniocalcin 1 0.0297963
NAV2 neuron navigator 2 0.0295601
ERRFI1 ERBB receptor feedback inhibitor 1 0.029508
FNIP1 folliculin interacting protein 1 0.0295015
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0292614
DSCAM Down syndrome cell adhesion molecule 0.028879
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.028861
RTN4 reticulon 4 0.0285351
SBF2 SET binding factor 2 0.0278594
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0276313
IQGAP1 IQ motif containing GTPase activating protein 1 0.0275787
USP34 ubiquitin specific peptidase 34 0.0275507
DPYSL2 dihydropyrimidinase-like 2 0.0273636
SUCO SUN domain containing ossification factor 0.0268838
MMP12 matrix metallopeptidase 12 0.0265088
SEPTIN9 septin 9 0.0258934
ARFGEF3 ARFGEF family member 3 0.0256109
FAM107B family with sequence similarity 107, member B 0.0251766
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0245357
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.024521
COL8A1 collagen, type VIII, alpha 1 0.0244755
BACE2 beta-site APP-cleaving enzyme 2 0.0243639
APP amyloid beta (A4) precursor protein 0.0240969
PRELID2 PRELI domain containing 2 0.0240855
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0240641
EIF1 eukaryotic translation initiation factor 1 0.023772
GARS1 glycyl-tRNA synthetase 1 0.0236627
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0233483
MXI1 MAX interactor 1, dimerization protein 0.0231918
SETD5 SET domain containing 5 0.0230184
ADM adrenomedullin 0.0230031
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0229422
THBS2 thrombospondin 2 0.0227444
ARRDC3 arrestin domain containing 3 0.0227364
SOD2 superoxide dismutase 2, mitochondrial 0.0225806
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0225132
ZFP36L1 ZFP36 ring finger protein-like 1 0.0224963
KLF6 Kruppel-like factor 6 0.0221992
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0217608
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0217602
KLHL24 kelch-like family member 24 0.0214594
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0210661
ZNF292 zinc finger protein 292 0.0210497
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0210275
MAP4 microtubule-associated protein 4 0.0208111
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0207149
DSPP dentin sialophosphoprotein 0.0203647
ZBTB20 zinc finger and BTB domain containing 20 0.0202798
HELZ helicase with zinc finger 0.0201656
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0201214
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0199139
UGCG UDP-glucose ceramide glucosyltransferase 0.0198071
DST dystonin 0.019516
GOLGA4 golgin A4 0.0193688
EGFR epidermal growth factor receptor 0.0192883
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0192793
ANXA2 annexin A2 0.0192244
PTK2 protein tyrosine kinase 2 0.0191673
SQSTM1 sequestosome 1 0.0191328
LOX lysyl oxidase 0.0189422
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0189314
PDIA6 protein disulfide isomerase family A, member 6 0.0187995
RNF24 ring finger protein 24 0.018784
PCBP2 poly(rC) binding protein 2 0.0187018
LIMCH1 LIM and calponin homology domains 1 0.0184123
DDIT4 DNA-damage-inducible transcript 4 0.0183528
YEATS2 YEATS domain containing 2 0.0183216
RUNX1 runt-related transcription factor 1 0.0182747
KMT2E lysine (K)-specific methyltransferase 2E 0.0182372
MYOF myoferlin 0.0181918
CYLD cylindromatosis (turban tumor syndrome) 0.0181468

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.107455
PODXL podocalyxin-like -0.0583024
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0461677
S100A10 S100 calcium binding protein A10 -0.0427849
COL5A1 collagen, type V, alpha 1 -0.0415503
FN1 fibronectin 1 -0.0377431
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.03312
RIGI RNA sensor RIG-I -0.0325979
PRSS23 protease, serine, 23 -0.0316835
MX2 MX dynamin-like GTPase 2 -0.030575
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0297713
LMNA lamin A/C -0.0289712
POTEF POTE ankyrin domain family, member F -0.0287622
SAMD9 sterile alpha motif domain containing 9 -0.0279807
CDH13 cadherin 13 -0.0269402
ABI3BP ABI family, member 3 (NESH) binding protein -0.0264423
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0259849
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0246415
AHNAK AHNAK nucleoprotein -0.0242066
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0241252
PLXNA2 plexin A2 -0.0240836
SUCNR1 succinate receptor 1 -0.0236943
ISG15 ISG15 ubiquitin-like modifier -0.0232749
S100A4 S100 calcium binding protein A4 -0.0230653
MEIS2 Meis homeobox 2 -0.0229179
LOC112694756 uncharaterized LOC112694756 -0.0225662
IFITM3 interferon induced transmembrane protein 3 -0.0221195
HLA-B major histocompatibility complex, class I, B -0.0217709
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0215416
MAP1B microtubule-associated protein 1B -0.0208137
SORBS2 sorbin and SH3 domain containing 2 -0.0204819
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0203153
HLA-C major histocompatibility complex, class I, C -0.0197014
CD59 CD59 molecule, complement regulatory protein -0.0196058
NAV1 neuron navigator 1 -0.0187575
IL7R interleukin 7 receptor -0.0187263
IFITM1 interferon induced transmembrane protein 1 -0.0185278
SMC4 structural maintenance of chromosomes 4 -0.018446
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0182849
IFI6 interferon, alpha-inducible protein 6 -0.0180121
LRRC17 leucine rich repeat containing 17 -0.0173294
COL5A2 collagen, type V, alpha 2 -0.0172565
FRMD4A FERM domain containing 4A -0.0170614
TPM1 tropomyosin 1 (alpha) -0.0169914
GLIS3 GLIS family zinc finger 3 -0.0169831
SP100 SP100 nuclear antigen -0.016976
MED13L mediator complex subunit 13-like -0.0166814
FLNA filamin A, alpha -0.0163534
OASL 2'-5'-oligoadenylate synthetase-like -0.0162503
RPL35A ribosomal protein L35a -0.0160514
SLC38A1 solute carrier family 38, member 1 -0.0159841
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0158169
ACTG1 actin gamma 1 -0.0156628
SAMD9L sterile alpha motif domain containing 9-like -0.015507
TNS3 tensin 3 -0.0150159
FBXL7 F-box and leucine-rich repeat protein 7 -0.0145883
TRABD2B TraB domain containing 2B -0.0144049
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0142932
TUBB4B tubulin, beta 4B class IVb -0.0142497
HSPB1 heat shock 27kDa protein 1 -0.014068
VEGFC vascular endothelial growth factor C -0.0140561
CCND1 cyclin D1 -0.0137182
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0136509
CDK6 cyclin-dependent kinase 6 -0.013361
MBNL1 muscleblind-like splicing regulator 1 -0.0133581
KRT81 keratin 81, type II -0.0133263
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0132938
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0131082
TUBB tubulin, beta class I -0.0129772
RPL28 ribosomal protein L28 -0.0129197
PMP22 peripheral myelin protein 22 -0.0127986
IPO9 importin 9 -0.0127977
TAGLN2 transgelin 2 -0.0127865
NPR2 natriuretic peptide receptor 2 -0.0126225
RACK1 receptor for activated C kinase 1 -0.0125768
RPLP1 ribosomal protein, large, P1 -0.0125703
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0124725
EDF1 endothelial differentiation-related factor 1 -0.0123427
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0123173
DGKG diacylglycerol kinase, gamma 90kDa -0.0122973
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.0122673
WWTR1 WW domain containing transcription regulator 1 -0.0122528
ECM1 extracellular matrix protein 1 -0.0122352
PCDH7 protocadherin 7 -0.0121677
RPS24 ribosomal protein S24 -0.0120752
RPL19 ribosomal protein L19 -0.011953
VAV2 vav 2 guanine nucleotide exchange factor -0.0119029
NALF1 NALCN channel auxiliary factor 1 -0.0118751
GSE1 Gse1 coiled-coil protein -0.01179
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0117684
IGFBP6 insulin-like growth factor binding protein 6 -0.0117682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0117489
FMN2 formin 2 -0.0114302
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.0114125
FLT1 fms-related tyrosine kinase 1 -0.011288
IFI16 interferon, gamma-inducible protein 16 -0.0110933
HMGB1 high mobility group box 1 -0.0110729
EFNA5 ephrin-A5 -0.0110104
ZNF217 zinc finger protein 217 -0.0109858
SCLT1 sodium channel and clathrin linker 1 -0.0109077