γ-Oryzanol_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.10507
PABPC1 poly(A) binding protein, cytoplasmic 1 0.101982
ANXA1 annexin A1 0.0999281
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0905626
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0898588
PCBP2 poly(rC) binding protein 2 0.076541
EEF2 eukaryotic translation elongation factor 2 0.0764847
USP34 ubiquitin specific peptidase 34 0.0586443
FXR1 fragile X mental retardation, autosomal homolog 1 0.0533188
TPM3 tropomyosin 3 0.0509361
CCNL1 cyclin L1 0.0469671
ZBTB20 zinc finger and BTB domain containing 20 0.0462304
KDM2A lysine (K)-specific demethylase 2A 0.0426039
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0420452
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0395288
AKAP9 A kinase (PRKA) anchor protein 9 0.03906
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0365404
MGAT4C MGAT4 family, member C 0.0362282
VMP1 vacuole membrane protein 1 0.0349449
PCM1 pericentriolar material 1 0.0347066
BPTF bromodomain PHD finger transcription factor 0.0345213
BCAS3 breast carcinoma amplified sequence 3 0.0344762
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0337275
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0336215
ZNF292 zinc finger protein 292 0.0334423
MED13L mediator complex subunit 13-like 0.0331013
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0319123
CEP192 centrosomal protein 192kDa 0.0294601
PLK2 polo-like kinase 2 0.0290682
CPOX coproporphyrinogen oxidase 0.0287989
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0282826
EXOC6B exocyst complex component 6B 0.0281502
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278947
KIF5B kinesin family member 5B 0.0276993
XPO1 exportin 1 0.0275708
PHF21A PHD finger protein 21A 0.0272736
MBD5 methyl-CpG binding domain protein 5 0.0266603
SMYD3 SET and MYND domain containing 3 0.0265906
TXNRD1 thioredoxin reductase 1 0.0261605
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0260694
KMT2C lysine (K)-specific methyltransferase 2C 0.0256197
FER fer (fps/fes related) tyrosine kinase 0.0255273
ZNF638 zinc finger protein 638 0.0248436
PRKCI protein kinase C, iota 0.0246986
ATP11B ATPase, class VI, type 11B 0.0246397
CCN2 cellular communication network factor 2 0.0243458
CDK19 cyclin-dependent kinase 19 0.0242631
GPBP1 GC-rich promoter binding protein 1 0.0240636
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0239721
TBC1D5 TBC1 domain family, member 5 0.0237258
SPATS2 spermatogenesis associated, serine-rich 2 0.0235286
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0234327
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0232323
ANKIB1 ankyrin repeat and IBR domain containing 1 0.023105
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0222993
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.022062
NCOR1 nuclear receptor corepressor 1 0.0219924
TPR translocated promoter region, nuclear basket protein 0.0219795
NEBL nebulette 0.0218698
RICTOR RPTOR independent companion of MTOR, complex 2 0.0216562
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0215191
NIPBL Nipped-B homolog (Drosophila) 0.0214209
DCAF6 DDB1 and CUL4 associated factor 6 0.0211962
LRP6 low density lipoprotein receptor-related protein 6 0.0210555
KLHL24 kelch-like family member 24 0.0210269
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0209186
EPHA6 EPH receptor A6 0.0208642
CAMKMT calmodulin-lysine N-methyltransferase 0.020774
TBK1 TANK-binding kinase 1 0.0206403
WNK1 WNK lysine deficient protein kinase 1 0.0204002
MBNL1 muscleblind-like splicing regulator 1 0.0203716
ECT2 epithelial cell transforming 2 0.0202875
EDN1 endothelin 1 0.0202091
PICALM phosphatidylinositol binding clathrin assembly protein 0.0200704
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.019697
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0194802
HELZ helicase with zinc finger 0.0193707
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0192368
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0192128
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0191667
ENAH enabled homolog (Drosophila) 0.01911
CLDND1 claudin domain containing 1 0.0190087
ARHGAP12 Rho GTPase activating protein 12 0.0189578
SMC4 structural maintenance of chromosomes 4 0.018888
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0188812
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.018811
NUP58 nucleoporin 58 0.0187878
SRRM1 serine/arginine repetitive matrix 1 0.0185955
UBA6 ubiquitin-like modifier activating enzyme 6 0.0185741
BIRC6 baculoviral IAP repeat containing 6 0.0185357
CCSER1 coiled-coil serine-rich protein 1 0.0184912
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0183192
CHD7 chromodomain helicase DNA binding protein 7 0.0182785
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0182659
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0180448
COPA coatomer protein complex, subunit alpha 0.0180308
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0180299
USP9X ubiquitin specific peptidase 9, X-linked 0.0179938
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0179172
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0178785

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.233256
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174894
PDE4D phosphodiesterase 4D, cAMP-specific -0.107753
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.106044
VIM vimentin -0.0941945
PTMA prothymosin, alpha -0.0904973
ACTG1 actin gamma 1 -0.0805442
NLGN1 neuroligin 1 -0.0754563
RPL35A ribosomal protein L35a -0.0743765
MYL12B myosin, light chain 12B, regulatory -0.0710771
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0693806
TPT1 tumor protein, translationally-controlled 1 -0.0672968
HMGA2 high mobility group AT-hook 2 -0.0621035
RPLP1 ribosomal protein, large, P1 -0.0611725
NAP1L1 nucleosome assembly protein 1-like 1 -0.057547
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0552202
FTL ferritin, light polypeptide -0.0543872
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.052546
RPL26 ribosomal protein L26 -0.0510081
RPL23 ribosomal protein L23 -0.050302
RPS6 ribosomal protein S6 -0.0472873
AHNAK AHNAK nucleoprotein -0.0456451
RPS24 ribosomal protein S24 -0.0448483
RPS21 ribosomal protein S21 -0.044048
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0431672
DLC1 DLC1 Rho GTPase activating protein -0.0427831
RPL11 ribosomal protein L11 -0.0426761
RPL34 ribosomal protein L34 -0.0424007
RPL19 ribosomal protein L19 -0.041147
RPL12 ribosomal protein L12 -0.0400022
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0380922
RPS8 ribosomal protein S8 -0.0378124
RPS27A ribosomal protein S27a -0.0377657
GNAS GNAS complex locus -0.0375257
PDGFC platelet derived growth factor C -0.0366437
RPS23 ribosomal protein S23 -0.0365066
RPLP2 ribosomal protein, large, P2 -0.0359233
RAB7A RAB7A, member RAS oncogene family -0.0353832
RPL37A ribosomal protein L37a -0.035128
RPL36 ribosomal protein L36 -0.0338408
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0335233
RPL37 ribosomal protein L37 -0.0333935
RPLP0 ribosomal protein, large, P0 -0.03325
ZNF804A zinc finger protein 804A -0.0332255
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0324121
RPS19 ribosomal protein S19 -0.0319321
CELF2 CUGBP, Elav-like family member 2 -0.0312559
RPL9 ribosomal protein L9 -0.0309431
IFIH1 interferon induced with helicase C domain 1 -0.0307903
BCHE butyrylcholinesterase -0.0306433
LOC112694756 uncharaterized LOC112694756 -0.0297544
RPS3 ribosomal protein S3 -0.0289582
RPS12 ribosomal protein S12 -0.0287075
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0281913
S100A10 S100 calcium binding protein A10 -0.0272401
YAP1 Yes-associated protein 1 -0.0268489
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0265736
RPS14 ribosomal protein S14 -0.0265068
RPL27A ribosomal protein L27a -0.0264403
VCL vinculin -0.0264321
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0261815
RPS29 ribosomal protein S29 -0.0259685
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0258363
RPL36A ribosomal protein L36a -0.0256472
YBX1 Y box binding protein 1 -0.0255342
RPL38 ribosomal protein L38 -0.0253139
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0253047
RPL31 ribosomal protein L31 -0.0246112
CNRIP1 cannabinoid receptor interacting protein 1 -0.0244567
CANX calnexin -0.024361
RPL13A ribosomal protein L13a -0.0240667
HMGB1 high mobility group box 1 -0.0238899
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0236105
ZNF217 zinc finger protein 217 -0.0232851
CCND1 cyclin D1 -0.0231757
EDARADD EDAR-associated death domain -0.0231669
KPNB1 karyopherin (importin) beta 1 -0.0229675
RACK1 receptor for activated C kinase 1 -0.0227163
RASAL2 RAS protein activator like 2 -0.0226143
RPL35 ribosomal protein L35 -0.0223274
TUBB tubulin, beta class I -0.0222994
RPL27 ribosomal protein L27 -0.0221586
RPS20 ribosomal protein S20 -0.0221483
RPS5 ribosomal protein S5 -0.0221425
HMGA1 high mobility group AT-hook 1 -0.0217806
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0216964
ATP5F1E ATP synthase F1 subunit epsilon -0.0216535
EIF1 eukaryotic translation initiation factor 1 -0.0213229
TMEM123 transmembrane protein 123 -0.021303
RPS13 ribosomal protein S13 -0.0210737
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.020704
SLC38A1 solute carrier family 38, member 1 -0.0205897
ANKRD11 ankyrin repeat domain 11 -0.020474
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0201614
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0201539
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0201506
CDK17 cyclin-dependent kinase 17 -0.0198732
TAS2R14 taste receptor, type 2, member 14 -0.0196997
KLF6 Kruppel-like factor 6 -0.0196815
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0195821