γ-Oryzanol_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.152883
LMO7 LIM domain 7 0.142592
SYNE2 spectrin repeat containing, nuclear envelope 2 0.12215
RNF213 ring finger protein 213 0.0968092
MBNL2 muscleblind-like splicing regulator 2 0.0967038
EPSTI1 epithelial stromal interaction 1 (breast) 0.0922268
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0918494
FNDC3B fibronectin type III domain containing 3B 0.0844691
ZMYND8 zinc finger, MYND-type containing 8 0.0824856
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0813982
CCNL1 cyclin L1 0.078987
DSPP dentin sialophosphoprotein 0.0755526
LYZ lysozyme 0.0716721
ZNF292 zinc finger protein 292 0.0689942
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0688193
GMDS GDP-mannose 4,6-dehydratase 0.0661945
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0656974
RAD51B RAD51 paralog B 0.0649705
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0610124
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0607113
ENO1 enolase 1, (alpha) 0.0587057
EXT1 exostosin glycosyltransferase 1 0.0572068
NPSR1 neuropeptide S receptor 1 0.0554728
ITGA6 integrin, alpha 6 0.0552768
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0551744
TSC22D1 TSC22 domain family, member 1 0.052998
BTBD9 BTB (POZ) domain containing 9 0.0525795
TRIO trio Rho guanine nucleotide exchange factor 0.0507952
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0503201
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0496805
TSHZ2 teashirt zinc finger homeobox 2 0.0483386
RIGI RNA sensor RIG-I 0.0482043
ARHGAP26 Rho GTPase activating protein 26 0.0480177
MX1 MX dynamin-like GTPase 1 0.0477007
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0474921
PHF3 PHD finger protein 3 0.0441915
EPS8 epidermal growth factor receptor pathway substrate 8 0.0440509
IGFBP3 insulin-like growth factor binding protein 3 0.0436652
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0432185
SP100 SP100 nuclear antigen 0.0425199
DST dystonin 0.0417059
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0416689
GOLGB1 golgin B1 0.0414022
VMP1 vacuole membrane protein 1 0.0408663
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.040674
MAML2 mastermind-like 2 (Drosophila) 0.0401702
KIF16B kinesin family member 16B 0.0393917
STS steroid sulfatase (microsomal), isozyme S 0.0377228
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0377026
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0374237
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0372154
EZR ezrin 0.0371277
EGR1 early growth response 1 0.034893
ERCC5 excision repair cross-complementation group 5 0.034717
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0346373
FNDC3A fibronectin type III domain containing 3A 0.0344329
GCLC glutamate-cysteine ligase, catalytic subunit 0.0337722
SORBS1 sorbin and SH3 domain containing 1 0.0332671
AREG amphiregulin 0.0331967
PRKCA protein kinase C, alpha 0.0331787
PGK1 phosphoglycerate kinase 1 0.0330299
ADAM10 ADAM metallopeptidase domain 10 0.0329035
TMED2 transmembrane emp24 domain trafficking protein 2 0.0325148
DSCAM Down syndrome cell adhesion molecule 0.0309994
PCED1B PC-esterase domain containing 1B 0.0307432
PADI1 peptidyl arginine deiminase, type I 0.0306577
AFF1 AF4/FMR2 family, member 1 0.030544
RAB6A RAB6A, member RAS oncogene family 0.0304692
DGKH diacylglycerol kinase, eta 0.0304315
IGF1R insulin-like growth factor 1 receptor 0.0304095
SSH2 slingshot protein phosphatase 2 0.0303162
AKAP13 A kinase (PRKA) anchor protein 13 0.0302712
MUC20 mucin 20, cell surface associated 0.030239
TAOK3 TAO kinase 3 0.0300456
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0299663
GRK3 G protein-coupled receptor kinase 3 0.0295923
COPA coatomer protein complex, subunit alpha 0.0294693
APOL1 apolipoprotein L, 1 0.0294204
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0292371
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0292236
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0291473
DSTN destrin (actin depolymerizing factor) 0.029002
MX2 MX dynamin-like GTPase 2 0.0289978
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0289681
ZFP36L1 ZFP36 ring finger protein-like 1 0.0286102
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.028392
BCLAF1 BCL2-associated transcription factor 1 0.0279799
AKAP9 A kinase (PRKA) anchor protein 9 0.0278739
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0277748
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0275913
LPP LIM domain containing preferred translocation partner in lipoma 0.0274948
MACC1 metastasis associated in colon cancer 1 0.0269586
PTK2 protein tyrosine kinase 2 0.0268886
SCARB1 scavenger receptor class B, member 1 0.0268882
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0267204
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0263419
VEGFA vascular endothelial growth factor A 0.0260875
CALR calreticulin 0.0260794
LOC102724023 ES1 protein homolog, mitochondrial 0.0258508
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0253987

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0884448
TPT1 tumor protein, translationally-controlled 1 -0.0882943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0724789
RHOBTB3 Rho-related BTB domain containing 3 -0.064087
RPS6 ribosomal protein S6 -0.0594052
RPLP1 ribosomal protein, large, P1 -0.0533831
RPL34 ribosomal protein L34 -0.0449472
HLA-C major histocompatibility complex, class I, C -0.0424344
RPL35A ribosomal protein L35a -0.040999
LOC112694756 uncharaterized LOC112694756 -0.040555
RPL23 ribosomal protein L23 -0.0377695
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0376012
RNF43 ring finger protein 43 -0.0307396
RPL7L1 ribosomal protein L7-like 1 -0.0306566
RPL19 ribosomal protein L19 -0.0303115
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0293471
LCN2 lipocalin 2 -0.0271158
RPL26 ribosomal protein L26 -0.0260347
ANKRD10 ankyrin repeat domain 10 -0.025439
SREBF2 sterol regulatory element binding transcription factor 2 -0.0250133
S100A6 S100 calcium binding protein A6 -0.0247356
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0245327
RUNX1 runt-related transcription factor 1 -0.0241634
RPLP0 ribosomal protein, large, P0 -0.0239243
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0239104
GNAS GNAS complex locus -0.0237859
SERINC5 serine incorporator 5 -0.0229867
SDC4 syndecan 4 -0.0228129
RPS24 ribosomal protein S24 -0.0222703
RPL12 ribosomal protein L12 -0.0219955
EIF1 eukaryotic translation initiation factor 1 -0.0217298
SHB Src homology 2 domain containing adaptor protein B -0.0215542
ATP11A ATPase, class VI, type 11A -0.0215005
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0213711
HMGB1 high mobility group box 1 -0.0205426
AHI1 Abelson helper integration site 1 -0.0204696
MARCHF6 membrane associated ring-CH-type finger 6 -0.0203821
HBS1L HBS1-like translational GTPase -0.0200764
RPL11 ribosomal protein L11 -0.0197384
RPL30 ribosomal protein L30 -0.0195669
NRIP1 nuclear receptor interacting protein 1 -0.0194455
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0186695
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.0186639
RPS28 ribosomal protein S28 -0.01854
HDLBP high density lipoprotein binding protein -0.018433
RPS8 ribosomal protein S8 -0.0182167
HMGB2 high mobility group box 2 -0.0174161
RRBP1 ribosome binding protein 1 -0.0170759
RPS23 ribosomal protein S23 -0.016446
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0164102
RPS13 ribosomal protein S13 -0.0162201
GLO1 glyoxalase I -0.0161954
RPL27A ribosomal protein L27a -0.0160998
HLA-A major histocompatibility complex, class I, A -0.0158929
HDAC4 histone deacetylase 4 -0.015818
FUS FUS RNA binding protein -0.0157915
FOXO3 forkhead box O3 -0.0157229
SH3RF1 SH3 domain containing ring finger 1 -0.0156092
SENP5 SUMO1/sentrin specific peptidase 5 -0.0156049
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0156022
HLA-E major histocompatibility complex, class I, E -0.0153507
RPS4X ribosomal protein S4, X-linked -0.0153377
ACTN4 actinin, alpha 4 -0.0152117
IER3 immediate early response 3 -0.0151569
RPL38 ribosomal protein L38 -0.015144
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0147334
WWOX WW domain containing oxidoreductase -0.0147296
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0146179
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0144098
MSI2 musashi RNA-binding protein 2 -0.0143769
SEC62 SEC62 homolog (S. cerevisiae) -0.0142664
PRSS2 protease, serine, 2 (trypsin 2) -0.0141775
RPS16 ribosomal protein S16 -0.0141415
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0140513
CD164 CD164 molecule, sialomucin -0.0138827
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0138017
H3-3B H3.3 histone B -0.0137997
FBXO9 F-box protein 9 -0.0137738
TTC39B tetratricopeptide repeat domain 39B -0.0136678
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0135765
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0135411
TMSB10 thymosin beta 10 -0.0134621
TMEM51 transmembrane protein 51 -0.0134537
RPL7 ribosomal protein L7 -0.0133442
RPL32 ribosomal protein L32 -0.0132665
RPLP2 ribosomal protein, large, P2 -0.0132464
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0132055
MECP2 methyl CpG binding protein 2 -0.0131311
S100A9 S100 calcium binding protein A9 -0.0131104
MATR3 matrin 3 -0.0130038
ITGB8 integrin, beta 8 -0.0129203
ARF1 ADP-ribosylation factor 1 -0.0129134
ATP5F1E ATP synthase F1 subunit epsilon -0.0129104
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0128714
CACUL1 CDK2-associated, cullin domain 1 -0.0127781
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0127361
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0127354
ELP4 elongator acetyltransferase complex subunit 4 -0.0127327
PHIP pleckstrin homology domain interacting protein -0.0127141
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0126376