γ-Oryzanol_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.149249
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.120877
PSD3 pleckstrin and Sec7 domain containing 3 0.101533
POTEF POTE ankyrin domain family, member F 0.0998853
DST dystonin 0.0935902
EEF2 eukaryotic translation elongation factor 2 0.0895805
KTN1 kinectin 1 (kinesin receptor) 0.0860431
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.08336
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0700373
ZDHHC14 zinc finger, DHHC-type containing 14 0.0687787
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0679114
TP63 tumor protein p63 0.0655824
PLK2 polo-like kinase 2 0.0628247
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0616721
FMNL2 formin-like 2 0.0613896
ZFP36L1 ZFP36 ring finger protein-like 1 0.0610574
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0590786
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0582721
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0569915
ENO1 enolase 1, (alpha) 0.0563609
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.053651
ERRFI1 ERBB receptor feedback inhibitor 1 0.0514979
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0511409
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0488965
EHBP1 EH domain binding protein 1 0.0485689
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0478099
CAPRIN2 caprin family member 2 0.0477541
AKAP9 A kinase (PRKA) anchor protein 9 0.0465688
RUNX1 runt-related transcription factor 1 0.0464785
SET SET nuclear proto-oncogene 0.0452477
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0435809
VMP1 vacuole membrane protein 1 0.0432271
ANGPTL4 angiopoietin-like 4 0.0431625
DPYD dihydropyrimidine dehydrogenase 0.042132
CCNL1 cyclin L1 0.0414376
ENO2 enolase 2 (gamma, neuronal) 0.0412378
USP34 ubiquitin specific peptidase 34 0.0410421
B2M beta-2-microglobulin 0.0408899
MKI67 marker of proliferation Ki-67 0.0407691
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0404247
RAD51B RAD51 paralog B 0.0399394
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0398402
TXNIP thioredoxin interacting protein 0.038286
LDHA lactate dehydrogenase A 0.0377421
BPTF bromodomain PHD finger transcription factor 0.0375994
CENPF centromere protein F, 350/400kDa 0.0373276
HDAC9 histone deacetylase 9 0.0371517
TSC22D1 TSC22 domain family, member 1 0.0363457
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0362482
EPHA4 EPH receptor A4 0.0359553
TPM3 tropomyosin 3 0.0343343
ZNF638 zinc finger protein 638 0.0340842
MBNL2 muscleblind-like splicing regulator 2 0.034031
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0339865
TPR translocated promoter region, nuclear basket protein 0.0335783
CADM2 cell adhesion molecule 2 0.033577
PRRC2C proline-rich coiled-coil 2C 0.0331885
APP amyloid beta (A4) precursor protein 0.0327486
PCBP2 poly(rC) binding protein 2 0.032254
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0321034
RNF213 ring finger protein 213 0.0319981
CDK19 cyclin-dependent kinase 19 0.0318625
MYADM myeloid-associated differentiation marker 0.0318143
JMJD1C jumonji domain containing 1C 0.0308295
EREG epiregulin 0.0308207
TIMP2 TIMP metallopeptidase inhibitor 2 0.0306598
SRRM2 serine/arginine repetitive matrix 2 0.0306017
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.030336
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0301902
KMT2E lysine (K)-specific methyltransferase 2E 0.0300595
OSBPL8 oxysterol binding protein-like 8 0.0297116
VEGFA vascular endothelial growth factor A 0.0296811
PKM pyruvate kinase, muscle 0.0294864
MBD5 methyl-CpG binding domain protein 5 0.0291903
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0291637
SRSF11 serine/arginine-rich splicing factor 11 0.0291623
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0290443
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0290295
PTPRF protein tyrosine phosphatase, receptor type, F 0.0290097
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0288817
BRD2 bromodomain containing 2 0.0288515
SLK STE20-like kinase 0.028814
CXCL8 chemokine (C-X-C motif) ligand 8 0.0286268
GCLM glutamate-cysteine ligase, modifier subunit 0.0286236
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0286118
XPO1 exportin 1 0.0285904
SLC38A2 solute carrier family 38, member 2 0.0284332
TBC1D5 TBC1 domain family, member 5 0.0281841
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0280706
PCM1 pericentriolar material 1 0.0277835
MBNL1 muscleblind-like splicing regulator 1 0.027696
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.027677
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0276619
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0274435
TNS3 tensin 3 0.0273024
BRD4 bromodomain containing 4 0.0269754
LPP LIM domain containing preferred translocation partner in lipoma 0.0267529
EGR1 early growth response 1 0.0265953
DNER delta/notch-like EGF repeat containing 0.0263852
CSNK1A1 casein kinase 1, alpha 1 0.0263767

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.284277
TMSB10 thymosin beta 10 -0.135333
LOC112694756 uncharaterized LOC112694756 -0.0825112
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0771613
AHNAK AHNAK nucleoprotein -0.0719296
RPL35A ribosomal protein L35a -0.0703077
RPL12 ribosomal protein L12 -0.0446212
RPLP1 ribosomal protein, large, P1 -0.0428566
TPT1 tumor protein, translationally-controlled 1 -0.0423301
KDM3A lysine (K)-specific demethylase 3A -0.041571
RPS8 ribosomal protein S8 -0.0400401
RPL26 ribosomal protein L26 -0.0382013
RPS24 ribosomal protein S24 -0.0380929
RTN4 reticulon 4 -0.0371486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0371363
PYGB phosphorylase, glycogen; brain -0.0354418
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0347372
HDLBP high density lipoprotein binding protein -0.03329
RPL23 ribosomal protein L23 -0.0328907
RPL34 ribosomal protein L34 -0.0328717
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0327478
WARS1 tryptophanyl-tRNA synthetase 1 -0.0324909
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0311529
GNAS GNAS complex locus -0.0307942
TMEM41B transmembrane protein 41B -0.0295537
RPS27A ribosomal protein S27a -0.0294495
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0277852
MARCHF6 membrane associated ring-CH-type finger 6 -0.0270694
RPL6 ribosomal protein L6 -0.0270601
ARF1 ADP-ribosylation factor 1 -0.0269421
RPLP0 ribosomal protein, large, P0 -0.0268813
BZW1 basic leucine zipper and W2 domains 1 -0.0266205
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0257291
RPL4 ribosomal protein L4 -0.0253633
RPS4X ribosomal protein S4, X-linked -0.0253517
YBX1 Y box binding protein 1 -0.0251557
RPL11 ribosomal protein L11 -0.0237125
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0235435
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.023367
NAMPT nicotinamide phosphoribosyltransferase -0.0231646
TMSB4X thymosin beta 4, X-linked -0.0231594
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.02308
SRGN serglycin -0.0228657
OLA1 Obg-like ATPase 1 -0.022853
RPL9 ribosomal protein L9 -0.0227828
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0225651
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0218182
RAB1A RAB1A, member RAS oncogene family -0.021748
RPL38 ribosomal protein L38 -0.0217466
CFDP1 craniofacial development protein 1 -0.0215878
GOLT1B golgi transport 1B -0.0214864
PDIA5 protein disulfide isomerase family A, member 5 -0.0213459
EMP1 epithelial membrane protein 1 -0.0211329
TMEM263 transmembrane protein 263 -0.0210813
CANX calnexin -0.0210747
RPS6 ribosomal protein S6 -0.0207098
RHEB Ras homolog enriched in brain -0.0205291
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0203682
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0203333
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0202014
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0201015
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0199927
RPS23 ribosomal protein S23 -0.019898
PTMA prothymosin, alpha -0.0195798
ZNF267 zinc finger protein 267 -0.0195721
SEPTIN2 septin 2 -0.0193303
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0192745
RRBP1 ribosome binding protein 1 -0.0191358
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0190943
AGO2 argonaute RISC catalytic component 2 -0.0190496
RPS20 ribosomal protein S20 -0.0189218
HMGB2 high mobility group box 2 -0.0187514
SLC38A1 solute carrier family 38, member 1 -0.0186641
MAPK8 mitogen-activated protein kinase 8 -0.0184726
RPL19 ribosomal protein L19 -0.0184386
RPL30 ribosomal protein L30 -0.0184313
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0184274
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0184204
MECP2 methyl CpG binding protein 2 -0.0182888
OGA O-GlcNAcase -0.0182127
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0182022
SPRY4 sprouty homolog 4 (Drosophila) -0.0179578
SENP5 SUMO1/sentrin specific peptidase 5 -0.0179144
ETNK1 ethanolamine kinase 1 -0.0176988
ZNF644 zinc finger protein 644 -0.0176263
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0176164
RPS28 ribosomal protein S28 -0.0175886
RPL37 ribosomal protein L37 -0.0175489
CALU calumenin -0.0174736
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0174734
ELOVL5 ELOVL fatty acid elongase 5 -0.0174637
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0174529
FBXO34 F-box protein 34 -0.0173177
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.017202
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.017146
NPR2 natriuretic peptide receptor 2 -0.017122
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0169604
ZFAND3 zinc finger, AN1-type domain 3 -0.0167512
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0166522
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0165943