γ-Oryzanol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.188201
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0968603
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.080862
GRAMD1B GRAM domain containing 1B 0.0807512
ANO6 anoctamin 6 0.0579624
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.051631
RTN4 reticulon 4 0.0494752
KDM2A lysine (K)-specific demethylase 2A 0.0491839
CCNL1 cyclin L1 0.0488395
TFPI2 tissue factor pathway inhibitor 2 0.0455868
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0440724
EEF2 eukaryotic translation elongation factor 2 0.0439855
COPA coatomer protein complex, subunit alpha 0.0438312
XPO1 exportin 1 0.0429072
RAD51B RAD51 paralog B 0.0420929
JMJD1C jumonji domain containing 1C 0.0411363
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0394793
GPHN gephyrin 0.0392981
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0392637
TRIO trio Rho guanine nucleotide exchange factor 0.0389346
NF1 neurofibromin 1 0.0387347
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0377013
EXOC6B exocyst complex component 6B 0.0373365
GATAD2B GATA zinc finger domain containing 2B 0.0365569
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0349273
CTTNBP2NL CTTNBP2 N-terminal like 0.0337185
SFPQ splicing factor proline/glutamine-rich 0.0333837
CSNK1A1 casein kinase 1, alpha 1 0.0333209
BIRC6 baculoviral IAP repeat containing 6 0.0330272
ERRFI1 ERBB receptor feedback inhibitor 1 0.032979
TBC1D5 TBC1 domain family, member 5 0.0323498
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0321744
AKAP9 A kinase (PRKA) anchor protein 9 0.0321689
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0320619
MMP12 matrix metallopeptidase 12 0.0320609
DST dystonin 0.0320139
SINHCAF SIN3-HDAC complex associated factor 0.0317971
ERBIN erbb2 interacting protein 0.0317057
ZFAND3 zinc finger, AN1-type domain 3 0.0314832
ZMYM2 zinc finger, MYM-type 2 0.0314503
RICTOR RPTOR independent companion of MTOR, complex 2 0.0309148
MARCHF4 membrane associated ring-CH-type finger 4 0.030693
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0306753
USP34 ubiquitin specific peptidase 34 0.0301688
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0300508
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0299341
ELL2 elongation factor, RNA polymerase II, 2 0.0295814
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0293135
RUSC2 RUN and SH3 domain containing 2 0.0292411
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0290082
MSN moesin 0.0289719
TPM3 tropomyosin 3 0.0284345
MKI67 marker of proliferation Ki-67 0.0280731
SLC38A2 solute carrier family 38, member 2 0.0271768
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0271147
ANKRD12 ankyrin repeat domain 12 0.0267201
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0263399
CLTC clathrin, heavy chain (Hc) 0.0262956
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0262911
AFF4 AF4/FMR2 family, member 4 0.0261666
TAOK1 TAO kinase 1 0.0259837
RASAL2 RAS protein activator like 2 0.0259724
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0259411
NIPBL Nipped-B homolog (Drosophila) 0.0258666
LATS2 large tumor suppressor kinase 2 0.0256402
ANKRD36 ankyrin repeat domain 36 0.025332
FAF1 Fas (TNFRSF6) associated factor 1 0.0252393
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0250911
BBX bobby sox homolog (Drosophila) 0.0247075
SETD5 SET domain containing 5 0.0246488
PCBP2 poly(rC) binding protein 2 0.0245947
VMP1 vacuole membrane protein 1 0.0241144
MED13L mediator complex subunit 13-like 0.024058
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0240324
NABP1 nucleic acid binding protein 1 0.0239755
RAB6A RAB6A, member RAS oncogene family 0.0234127
WDPCP WD repeat containing planar cell polarity effector 0.0233985
DOCK5 dedicator of cytokinesis 5 0.0232695
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0232128
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0231745
CSDE1 cold shock domain containing E1, RNA-binding 0.0230913
BPTF bromodomain PHD finger transcription factor 0.0229009
NOTCH2 notch 2 0.0227772
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0227582
DARS1 aspartyl-tRNA synthetase 1 0.0226516
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0225669
R3HDM2 R3H domain containing 2 0.0224548
PTK2 protein tyrosine kinase 2 0.0224349
SND1 staphylococcal nuclease and tudor domain containing 1 0.0222943
RNF38 ring finger protein 38 0.0222499
PCM1 pericentriolar material 1 0.0220298
ADAM10 ADAM metallopeptidase domain 10 0.0219615
SERINC3 serine incorporator 3 0.0219132
SCAF11 SR-related CTD-associated factor 11 0.0219038
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0217357
RANBP17 RAN binding protein 17 0.0216827
CUL3 cullin 3 0.0216661
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0216623
BCAS3 breast carcinoma amplified sequence 3 0.0214809
WNK1 WNK lysine deficient protein kinase 1 0.0212599

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.244187
TMSB10 thymosin beta 10 -0.139745
PTMA prothymosin, alpha -0.121453
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116856
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0780109
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0769959
VIM vimentin -0.0596417
MCL1 myeloid cell leukemia 1 -0.0565438
RPL23 ribosomal protein L23 -0.0548926
RPS8 ribosomal protein S8 -0.0521403
RPL35A ribosomal protein L35a -0.0513722
RPL37A ribosomal protein L37a -0.0502373
RPLP1 ribosomal protein, large, P1 -0.0497021
RPL26 ribosomal protein L26 -0.0485392
RPS21 ribosomal protein S21 -0.043743
TPT1 tumor protein, translationally-controlled 1 -0.0432869
RPS12 ribosomal protein S12 -0.0430992
ACTG1 actin gamma 1 -0.0421264
RPS19 ribosomal protein S19 -0.0420226
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0413095
RPL37 ribosomal protein L37 -0.0398304
RPS27A ribosomal protein S27a -0.0388754
IFI6 interferon, alpha-inducible protein 6 -0.0386891
RPL34 ribosomal protein L34 -0.0384835
RPS3 ribosomal protein S3 -0.0381164
YBX1 Y box binding protein 1 -0.0380269
RYR3 ryanodine receptor 3 -0.037497
RPS29 ribosomal protein S29 -0.0374282
RPL12 ribosomal protein L12 -0.0365613
RPS15 ribosomal protein S15 -0.036233
HLA-B major histocompatibility complex, class I, B -0.0360537
HMGA2 high mobility group AT-hook 2 -0.0360503
TPM2 tropomyosin 2 (beta) -0.035942
RPS24 ribosomal protein S24 -0.0348375
RPS27 ribosomal protein S27 -0.0345749
PRELID2 PRELI domain containing 2 -0.0341393
S100A10 S100 calcium binding protein A10 -0.0334357
THSD4 thrombospondin, type I, domain containing 4 -0.0325333
RPL36 ribosomal protein L36 -0.0324585
RPL38 ribosomal protein L38 -0.0323462
CALR calreticulin -0.0322236
NCOA7 nuclear receptor coactivator 7 -0.0320848
RPLP2 ribosomal protein, large, P2 -0.031084
FTL ferritin, light polypeptide -0.0296778
FNDC3B fibronectin type III domain containing 3B -0.0296424
RPL31 ribosomal protein L31 -0.0295211
WWOX WW domain containing oxidoreductase -0.0289543
RPL19 ribosomal protein L19 -0.0281131
GNAS GNAS complex locus -0.0279016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0274983
RPS17 ribosomal protein S17 -0.0274554
RPL11 ribosomal protein L11 -0.027277
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0270885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.02661
CAVIN1 caveolae associated protein 1 -0.026165
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0253198
RPS20 ribosomal protein S20 -0.0251381
NAP1L1 nucleosome assembly protein 1-like 1 -0.0250137
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.02481
RPL8 ribosomal protein L8 -0.0244949
PDE10A phosphodiesterase 10A -0.0243385
IER3 immediate early response 3 -0.0238559
RPL32 ribosomal protein L32 -0.0237679
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0233538
AKAP12 A kinase (PRKA) anchor protein 12 -0.0231435
RPL35 ribosomal protein L35 -0.0224027
RAB7A RAB7A, member RAS oncogene family -0.0218193
RACK1 receptor for activated C kinase 1 -0.0217951
RPS4X ribosomal protein S4, X-linked -0.0212941
RPS6 ribosomal protein S6 -0.0208003
RPL27 ribosomal protein L27 -0.0207534
RPL28 ribosomal protein L28 -0.0205927
RPL7A ribosomal protein L7a -0.0205426
RPS16 ribosomal protein S16 -0.0205387
RPS2 ribosomal protein S2 -0.0200514
PRH1 proline-rich protein HaeIII subfamily 1 -0.0200403
NEK10 NIMA-related kinase 10 -0.0199993
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0199644
RIMS2 regulating synaptic membrane exocytosis 2 -0.0195249
TRA2A transformer 2 alpha homolog (Drosophila) -0.0194879
RPS23 ribosomal protein S23 -0.0193572
RPS25 ribosomal protein S25 -0.0192505
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0188504
RPL9 ribosomal protein L9 -0.0188484
STYK1 serine/threonine/tyrosine kinase 1 -0.0188474
RPS10 ribosomal protein S10 -0.0187829
AEBP2 AE binding protein 2 -0.0186435
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0186432
AHNAK AHNAK nucleoprotein -0.0185838
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0185331
PDLIM5 PDZ and LIM domain 5 -0.0184574
LRRC23 leucine rich repeat containing 23 -0.0184074
ARMH4 armadillo like helical domain containing 4 -0.0183409
RPL5 ribosomal protein L5 -0.0177097
STPG4 sperm-tail PG-rich repeat containing 4 -0.0176065
SEPTIN2 septin 2 -0.0174819
ATP5F1E ATP synthase F1 subunit epsilon -0.0174152
WNT2B wingless-type MMTV integration site family, member 2B -0.0172818
TEX14 testis expressed 14 -0.0171795
CANX calnexin -0.0170845