γ-Oryzanol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.228696
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.183183
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0997056
VEGFA vascular endothelial growth factor A 0.0967896
EEF2 eukaryotic translation elongation factor 2 0.0903563
AKAP12 A kinase (PRKA) anchor protein 12 0.0892051
ADM adrenomedullin 0.0824826
UGCG UDP-glucose ceramide glucosyltransferase 0.0756953
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.075337
ZFP36L1 ZFP36 ring finger protein-like 1 0.0665396
FTL ferritin, light polypeptide 0.0638324
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0634449
B2M beta-2-microglobulin 0.0606359
IGFBP3 insulin-like growth factor binding protein 3 0.0603465
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.059452
NDRG1 N-myc downstream regulated 1 0.0544669
TXNIP thioredoxin interacting protein 0.0506301
FN1 fibronectin 1 0.0505618
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0501098
LDHA lactate dehydrogenase A 0.0493953
VCAN versican 0.0475848
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.044706
PLIN2 perilipin 2 0.0414342
VMP1 vacuole membrane protein 1 0.0413676
UBC ubiquitin C 0.0412267
EIF1 eukaryotic translation initiation factor 1 0.0407927
STC2 stanniocalcin 2 0.0394326
CDK19 cyclin-dependent kinase 19 0.0391571
SLC38A2 solute carrier family 38, member 2 0.0389419
OPTN optineurin 0.0388963
SFTPA2 surfactant protein A2 0.0375366
AKAP9 A kinase (PRKA) anchor protein 9 0.0372385
BPTF bromodomain PHD finger transcription factor 0.0368675
PCBP2 poly(rC) binding protein 2 0.0359399
TIMP2 TIMP metallopeptidase inhibitor 2 0.0352955
STC1 stanniocalcin 1 0.0349446
WASF2 WAS protein family, member 2 0.0336971
DIAPH2 diaphanous-related formin 2 0.0332115
EHBP1 EH domain binding protein 1 0.0331947
BTG1 B-cell translocation gene 1, anti-proliferative 0.033001
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0320777
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0312133
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0308963
RAI14 retinoic acid induced 14 0.0308946
BRD2 bromodomain containing 2 0.0308508
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0308446
RND3 Rho family GTPase 3 0.0306515
FNIP1 folliculin interacting protein 1 0.0306317
CCNL1 cyclin L1 0.0301752
SNX3 sorting nexin 3 0.0301741
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0296597
HDAC9 histone deacetylase 9 0.029565
FRMD4A FERM domain containing 4A 0.0290579
MBNL1 muscleblind-like splicing regulator 1 0.0289528
EGR1 early growth response 1 0.0289054
RPS6 ribosomal protein S6 0.0286244
HLA-A major histocompatibility complex, class I, A 0.0286183
HMGA2 high mobility group AT-hook 2 0.0283544
TNS3 tensin 3 0.0276474
MT2A metallothionein 2A 0.0255191
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0254768
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0254035
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0253954
UBA6 ubiquitin-like modifier activating enzyme 6 0.0250702
CXCL8 chemokine (C-X-C motif) ligand 8 0.0249087
C3 complement component 3 0.0249073
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0248011
BASP1 brain abundant, membrane attached signal protein 1 0.0247348
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0246943
ASTN2 astrotactin 2 0.0244506
ENO2 enolase 2 (gamma, neuronal) 0.0243624
EGFR epidermal growth factor receptor 0.0241377
DEPP1 DEPP autophagy regulator 1 0.0237903
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0237541
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0235818
LOC102724023 ES1 protein homolog, mitochondrial 0.0235649
PCM1 pericentriolar material 1 0.0234512
MSN moesin 0.023424
ESYT2 extended synaptotagmin-like protein 2 0.0233789
KMT2E lysine (K)-specific methyltransferase 2E 0.0232528
ZCCHC7 zinc finger, CCHC domain containing 7 0.0232305
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.023008
TAOK3 TAO kinase 3 0.0229607
JUN jun proto-oncogene 0.0229461
NBEAL1 neurobeachin-like 1 0.0223151
RPS13 ribosomal protein S13 0.0221215
SERINC3 serine incorporator 3 0.0219763
FNBP4 formin binding protein 4 0.0218707
MYADM myeloid-associated differentiation marker 0.0218023
GRN granulin 0.0217172
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0217029
MMP12 matrix metallopeptidase 12 0.0216889
N4BP2L2 NEDD4 binding protein 2-like 2 0.0215248
FLNB filamin B, beta 0.02145
TMF1 TATA element modulatory factor 1 0.0214237
CSDE1 cold shock domain containing E1, RNA-binding 0.021065
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0210241
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0207939
SCARB1 scavenger receptor class B, member 1 0.0207825
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0206427

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.111066
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.110848
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0777208
MYH9 myosin, heavy chain 9, non-muscle -0.0757544
NAMPT nicotinamide phosphoribosyltransferase -0.06578
FNDC3B fibronectin type III domain containing 3B -0.0655894
STAT1 signal transducer and activator of transcription 1, 91kDa -0.060836
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0596009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0573296
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0461492
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0443576
NAV2 neuron navigator 2 -0.0420756
RTN4 reticulon 4 -0.037499
ZFAND3 zinc finger, AN1-type domain 3 -0.0371217
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0362945
TPT1 tumor protein, translationally-controlled 1 -0.0354451
RRBP1 ribosome binding protein 1 -0.0353383
VCL vinculin -0.0347139
HLA-C major histocompatibility complex, class I, C -0.0344942
RBM39 RNA binding motif protein 39 -0.0336058
FLNA filamin A, alpha -0.0327391
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.032118
KDM3A lysine (K)-specific demethylase 3A -0.0318617
SPAG9 sperm associated antigen 9 -0.0316585
SOD2 superoxide dismutase 2, mitochondrial -0.0305762
TMSB10 thymosin beta 10 -0.030346
RPL23 ribosomal protein L23 -0.0302792
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0298973
RPL26 ribosomal protein L26 -0.0287761
ZNFX1 zinc finger, NFX1-type containing 1 -0.0287588
MAPK8 mitogen-activated protein kinase 8 -0.0277167
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0276492
RIGI RNA sensor RIG-I -0.0270939
DENND5A DENN/MADD domain containing 5A -0.0270907
IFI16 interferon, gamma-inducible protein 16 -0.0269223
THBS2 thrombospondin 2 -0.0269202
AFDN afadin, adherens junction formation factor -0.0260494
SMAD3 SMAD family member 3 -0.0253435
IER3 immediate early response 3 -0.0252086
ICAM1 intercellular adhesion molecule 1 -0.0250556
RPS24 ribosomal protein S24 -0.0245012
OSMR oncostatin M receptor -0.0239469
SYAP1 synapse associated protein 1 -0.0238733
SLC38A1 solute carrier family 38, member 1 -0.023564
TPM4 tropomyosin 4 -0.0234484
AHNAK AHNAK nucleoprotein -0.0234159
BICC1 BicC family RNA binding protein 1 -0.0231573
TOP1 topoisomerase (DNA) I -0.0228584
RAD21 RAD21 homolog (S. pombe) -0.0225416
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0225008
RPL35A ribosomal protein L35a -0.0221463
TM9SF3 transmembrane 9 superfamily member 3 -0.0221452
NAV1 neuron navigator 1 -0.0220706
SRGN serglycin -0.0219879
CRY1 cryptochrome circadian clock 1 -0.0210032
EXT1 exostosin glycosyltransferase 1 -0.0209173
KLF6 Kruppel-like factor 6 -0.0208419
RPL4 ribosomal protein L4 -0.0208382
NPR2 natriuretic peptide receptor 2 -0.0205394
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0205058
RAD51B RAD51 paralog B -0.0205007
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0203814
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0201794
SNX9 sorting nexin 9 -0.0201286
ANKRD10 ankyrin repeat domain 10 -0.0201148
RPL6 ribosomal protein L6 -0.0200749
WTAP Wilms tumor 1 associated protein -0.0196771
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0195572
MX1 MX dynamin-like GTPase 1 -0.0195461
LOC112694756 uncharaterized LOC112694756 -0.0195455
GLIPR1 GLI pathogenesis-related 1 -0.0191981
RPS2 ribosomal protein S2 -0.0190837
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0190809
NT5E 5'-nucleotidase, ecto (CD73) -0.0188439
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0187651
PSD3 pleckstrin and Sec7 domain containing 3 -0.0186211
PTK2 protein tyrosine kinase 2 -0.0186142
NALF1 NALCN channel auxiliary factor 1 -0.0185905
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0184556
WDR26 WD repeat domain 26 -0.0183632
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0183596
GNAS GNAS complex locus -0.0182346
PRRC2B proline-rich coiled-coil 2B -0.0181521
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0180781
PDE10A phosphodiesterase 10A -0.0179568
TNNC1 troponin C type 1 (slow) -0.0177631
HMGB1 high mobility group box 1 -0.0176791
TRAF3IP2 TRAF3 interacting protein 2 -0.0176779
KLHL5 kelch-like family member 5 -0.0176771
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0176392
TBC1D5 TBC1 domain family, member 5 -0.0176103
THBS1 thrombospondin 1 -0.0175875
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0173523
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0173521
STAT2 signal transducer and activator of transcription 2, 113kDa -0.0171642
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0170357
NUP98 nucleoporin 98kDa -0.0168062
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0165767
LCORL ligand dependent nuclear receptor corepressor-like -0.0165314
UBE2O ubiquitin-conjugating enzyme E2O -0.0165238