γ-Oryzanol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.124237
AKAP9 A kinase (PRKA) anchor protein 9 0.0918558
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0788774
TTC3 tetratricopeptide repeat domain 3 0.0657477
PRRC2C proline-rich coiled-coil 2C 0.0592755
COL6A3 collagen, type VI, alpha 3 0.0539333
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0535001
NAMPT nicotinamide phosphoribosyltransferase 0.051689
RNF145 ring finger protein 145 0.0506225
IL6 interleukin 6 0.050276
KDM2A lysine (K)-specific demethylase 2A 0.0492209
VIM vimentin 0.0487099
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0461767
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0447964
SEC31A SEC31 homolog A (S. cerevisiae) 0.0447248
RAB1A RAB1A, member RAS oncogene family 0.0443019
STC1 stanniocalcin 1 0.0422093
THOC2 THO complex 2 0.0417198
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.041601
COPA coatomer protein complex, subunit alpha 0.0415195
LMAN1 lectin, mannose-binding, 1 0.0409246
RBM25 RNA binding motif protein 25 0.0398908
TM4SF1 transmembrane 4 L six family member 1 0.0388159
DYNC2I1 dynein 2 intermediate chain 1 0.0371351
ASPH aspartate beta-hydroxylase 0.0366623
MACF1 microtubule-actin crosslinking factor 1 0.0365489
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0365453
DSCAM Down syndrome cell adhesion molecule 0.0362925
SAMD4A sterile alpha motif domain containing 4A 0.0362874
ANXA2 annexin A2 0.0360103
ANXA5 annexin A5 0.0358964
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0358579
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0356558
ZCCHC7 zinc finger, CCHC domain containing 7 0.0346081
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0343867
PTK2 protein tyrosine kinase 2 0.0340204
GPBP1 GC-rich promoter binding protein 1 0.0338937
BBS9 Bardet-Biedl syndrome 9 0.0338784
PGK1 phosphoglycerate kinase 1 0.0334623
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0331848
DDIT4 DNA-damage-inducible transcript 4 0.0325982
FKBP10 FK506 binding protein 10, 65 kDa 0.0325531
SPAG9 sperm associated antigen 9 0.0323867
BPTF bromodomain PHD finger transcription factor 0.0322168
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0320655
GCC2 GRIP and coiled-coil domain containing 2 0.0320114
SCAMP1 secretory carrier membrane protein 1 0.0315047
SCFD1 sec1 family domain containing 1 0.0313837
RHOA ras homolog family member A 0.031066
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0307129
MON2 MON2 homolog (S. cerevisiae) 0.0306748
LIMS1 LIM and senescent cell antigen-like domains 1 0.030239
DNAAF9 dynein axonemal assembly factor 9 0.0299714
VDAC1 voltage-dependent anion channel 1 0.029877
CALR calreticulin 0.029261
WDFY2 WD repeat and FYVE domain containing 2 0.0289747
STC2 stanniocalcin 2 0.0289618
TIMP3 TIMP metallopeptidase inhibitor 3 0.0288263
WDR26 WD repeat domain 26 0.0286959
LOX lysyl oxidase 0.0283674
RPS19 ribosomal protein S19 0.0280195
GOLGA4 golgin A4 0.0280138
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.02776
MMP12 matrix metallopeptidase 12 0.0277426
CAPN2 calpain 2, (m/II) large subunit 0.0272682
EHBP1 EH domain binding protein 1 0.0272275
CIRSR corepressor of RBPJ and splicing regulator 0.0271828
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0271541
GOLGB1 golgin B1 0.027076
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0270261
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0267849
CDK17 cyclin-dependent kinase 17 0.0266828
USP34 ubiquitin specific peptidase 34 0.0264117
EXOC4 exocyst complex component 4 0.0263483
TENT5A terminal nucleotidyltransferase 5A 0.0263031
TRIO trio Rho guanine nucleotide exchange factor 0.0262123
BIRC6 baculoviral IAP repeat containing 6 0.0261796
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0256933
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0256893
STAU1 staufen double-stranded RNA binding protein 1 0.0256062
LAMB3 laminin, beta 3 0.0254805
COL5A2 collagen, type V, alpha 2 0.0254375
IKBIP IKBKB interacting protein 0.0253846
TMED9 transmembrane emp24 protein transport domain containing 9 0.0253779
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0253677
PTPRM protein tyrosine phosphatase, receptor type, M 0.0250242
NCKAP1 NCK-associated protein 1 0.0249032
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0248437
TBC1D23 TBC1 domain family, member 23 0.0247464
BCL2L1 BCL2-like 1 0.0245795
EGFR epidermal growth factor receptor 0.0244908
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0244175
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0242315
ACTN1 actinin, alpha 1 0.0241964
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0241905
MORF4L2 mortality factor 4 like 2 0.02414
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0241307
PDE8A phosphodiesterase 8A 0.0240365
FTL ferritin, light polypeptide 0.0240156
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.023874

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.196394
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109181
B2M beta-2-microglobulin -0.108238
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0862059
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0822831
MEF2A myocyte enhancer factor 2A -0.0763751
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0749405
IGFBP3 insulin-like growth factor binding protein 3 -0.0735665
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0708405
ZNF395 zinc finger protein 395 -0.0646578
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0618319
PTMA prothymosin, alpha -0.0571259
SMYD3 SET and MYND domain containing 3 -0.056964
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0526952
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0521698
TRA2A transformer 2 alpha homolog (Drosophila) -0.0519261
ANLN anillin, actin binding protein -0.0503781
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0500906
IGFBP7 insulin-like growth factor binding protein 7 -0.0490975
PRELID2 PRELI domain containing 2 -0.0476182
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0469558
FUS FUS RNA binding protein -0.0453544
SETD5 SET domain containing 5 -0.0450372
FAM13B family with sequence similarity 13, member B -0.0445819
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0439084
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0432681
PDIA4 protein disulfide isomerase family A, member 4 -0.0423366
PRKCA protein kinase C, alpha -0.0410006
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.04088
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0405992
AVL9 AVL9 homolog (S. cerevisiase) -0.0402945
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0400697
MAPK8 mitogen-activated protein kinase 8 -0.0396753
CCDC88A coiled-coil domain containing 88A -0.0387641
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0384637
FNDC3B fibronectin type III domain containing 3B -0.0382893
SUB1 SUB1 homolog (S. cerevisiae) -0.037866
JARID2 jumonji, AT rich interactive domain 2 -0.037097
ELL2 elongation factor, RNA polymerase II, 2 -0.0368681
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0368005
MYOF myoferlin -0.036564
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0363793
TGFBI transforming growth factor, beta-induced, 68kDa -0.0363345
RPS2 ribosomal protein S2 -0.0359778
CKAP5 cytoskeleton associated protein 5 -0.0358992
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0353466
COL6A1 collagen, type VI, alpha 1 -0.0350939
PPME1 protein phosphatase methylesterase 1 -0.0347009
RNF24 ring finger protein 24 -0.0344211
LCORL ligand dependent nuclear receptor corepressor-like -0.0341377
COL4A1 collagen, type IV, alpha 1 -0.0337513
WDPCP WD repeat containing planar cell polarity effector -0.0337114
WDR45B WD repeat domain 45B -0.0335123
TENT4A terminal nucleotidyltransferase 4A -0.0334094
CCNI cyclin I -0.0332916
STAG2 stromal antigen 2 -0.0329665
DPYD dihydropyrimidine dehydrogenase -0.0327368
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0323203
SYNRG synergin, gamma -0.0316946
LAMB1 laminin, beta 1 -0.0315605
KMT2E lysine (K)-specific methyltransferase 2E -0.0314333
SDK1 sidekick cell adhesion molecule 1 -0.0313473
IARS1 isoleucyl-tRNA synthetase 1 -0.0312737
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0312152
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0309387
AKAP12 A kinase (PRKA) anchor protein 12 -0.0308213
MKI67 marker of proliferation Ki-67 -0.0307537
ATP11B ATPase, class VI, type 11B -0.0304213
COL5A1 collagen, type V, alpha 1 -0.0304085
SMAD3 SMAD family member 3 -0.0303841
UBE2H ubiquitin-conjugating enzyme E2H -0.0301821
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0299103
ANKRD33B ankyrin repeat domain 33B -0.0296405
CAV1 caveolin 1, caveolae protein, 22kDa -0.0294451
CDC42SE2 CDC42 small effector 2 -0.029301
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0292563
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0290953
RPL11 ribosomal protein L11 -0.0287206
RERE arginine-glutamic acid dipeptide (RE) repeats -0.028499
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0284383
PTN pleiotrophin -0.0283961
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0281831
SKIC3 SKI3 subunit of superkiller complex -0.0281215
ZSWIM6 zinc finger, SWIM-type containing 6 -0.028063
RACK1 receptor for activated C kinase 1 -0.0280572
UBXN4 UBX domain protein 4 -0.0279582
LDHA lactate dehydrogenase A -0.0277192
CKAP2 cytoskeleton associated protein 2 -0.0277163
HOOK2 hook microtubule-tethering protein 2 -0.0274279
RAD51B RAD51 paralog B -0.027227
JAG1 jagged 1 -0.0269816
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0269744
SCAF11 SR-related CTD-associated factor 11 -0.0268084
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0266046
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0265298
MBNL1 muscleblind-like splicing regulator 1 -0.0264818
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0264783
CADM1 cell adhesion molecule 1 -0.0264575
MAML3 mastermind-like 3 (Drosophila) -0.0263238
PDS5B PDS5 cohesin associated factor B -0.026261