γ-Oryzanol_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description γ-Oryzanol perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the γ-Oryzanol_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0983754
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0732818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0680931
TPX2 TPX2, microtubule-associated 0.0592426
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0583107
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0579782
KIF5B kinesin family member 5B 0.0567269
PTMA prothymosin, alpha 0.0565262
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.053984
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0536445
IGFBP3 insulin-like growth factor binding protein 3 0.0486447
NAMPT nicotinamide phosphoribosyltransferase 0.0473208
CALU calumenin 0.045426
EEF2 eukaryotic translation elongation factor 2 0.0447164
SMC4 structural maintenance of chromosomes 4 0.0447023
ANLN anillin, actin binding protein 0.0434067
AKAP9 A kinase (PRKA) anchor protein 9 0.0423111
CENPF centromere protein F, 350/400kDa 0.041716
CKAP2 cytoskeleton associated protein 2 0.0413484
ANXA1 annexin A1 0.0402977
TXNRD1 thioredoxin reductase 1 0.0397878
NUP58 nucleoporin 58 0.0397613
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0387473
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0385726
MKI67 marker of proliferation Ki-67 0.0377388
DSCAM Down syndrome cell adhesion molecule 0.0376583
DIAPH3 diaphanous-related formin 3 0.0373297
CKAP5 cytoskeleton associated protein 5 0.0365649
MIS18BP1 MIS18 binding protein 1 0.0360619
SQSTM1 sequestosome 1 0.0354419
YAP1 Yes-associated protein 1 0.0350005
SRP54 signal recognition particle 54kDa 0.0343913
ANKRD28 ankyrin repeat domain 28 0.0343267
GOLGB1 golgin B1 0.0340289
MT2A metallothionein 2A 0.0337957
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0337144
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0335764
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0333947
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0330176
HILPDA hypoxia inducible lipid droplet-associated 0.0328041
COG5 component of oligomeric golgi complex 5 0.0327521
APLP2 amyloid beta (A4) precursor-like protein 2 0.0326128
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0324904
SYCP2 synaptonemal complex protein 2 0.0321295
RSRC2 arginine/serine-rich coiled-coil 2 0.0317357
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0315661
MORF4L2 mortality factor 4 like 2 0.0314201
SPAG9 sperm associated antigen 9 0.0313746
YBX3 Y box binding protein 3 0.0311407
DEK DEK proto-oncogene 0.0310864
RBM39 RNA binding motif protein 39 0.0310726
KIAA1958 KIAA1958 0.0309655
CEP250 centrosomal protein 250kDa 0.0303274
NIPBL Nipped-B homolog (Drosophila) 0.0301921
RPS12 ribosomal protein S12 0.0301563
CANX calnexin 0.0301066
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0298137
KIAA1328 KIAA1328 0.0293395
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0289399
NCAPD2 non-SMC condensin I complex, subunit D2 0.0284179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0284154
IARS1 isoleucyl-tRNA synthetase 1 0.0281795
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0279974
SGO2 shugoshin 2 0.0275431
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0273313
EIF1 eukaryotic translation initiation factor 1 0.0272271
ECT2 epithelial cell transforming 2 0.0270583
HJURP Holliday junction recognition protein 0.0268081
PIBF1 progesterone immunomodulatory binding factor 1 0.0264688
RBM27 RNA binding motif protein 27 0.0264591
RB1CC1 RB1-inducible coiled-coil 1 0.0260795
RPL37A ribosomal protein L37a 0.0260609
ARL15 ADP-ribosylation factor-like 15 0.0260605
GARS1 glycyl-tRNA synthetase 1 0.0260506
RAB1A RAB1A, member RAS oncogene family 0.0260464
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0259573
CCNB1 cyclin B1 0.0255837
PAPOLA poly(A) polymerase alpha 0.0250976
COPB1 coatomer protein complex, subunit beta 1 0.0250213
SKP1 S-phase kinase-associated protein 1 0.024877
ANKHD1 ankyrin repeat and KH domain containing 1 0.0248061
CDC27 cell division cycle 27 0.0248004
RRBP1 ribosome binding protein 1 0.0246953
TM9SF2 transmembrane 9 superfamily member 2 0.024555
CEP295 centrosomal protein 295kDa 0.0243962
PCBP2 poly(rC) binding protein 2 0.0243178
ATP11B ATPase, class VI, type 11B 0.0243151
PDGFA platelet-derived growth factor alpha polypeptide 0.0242011
FUS FUS RNA binding protein 0.0241855
MATR3 matrin 3 0.0239152
FAM13A family with sequence similarity 13, member A 0.0238464
KIF20B kinesin family member 20B 0.0236943
FRYL FRY-like 0.0235933
PDE4D phosphodiesterase 4D, cAMP-specific 0.0235813
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0234172
KNL1 kinetochore scaffold 1 0.0233102
WDR45B WD repeat domain 45B 0.0233077
RPL12 ribosomal protein L12 0.023278
AFF4 AF4/FMR2 family, member 4 0.0229911
CLTC clathrin, heavy chain (Hc) 0.0229307

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.113295
PRKCA protein kinase C, alpha -0.0922099
DST dystonin -0.0783324
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0685868
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0656279
HMGA2 high mobility group AT-hook 2 -0.0620183
TMSB10 thymosin beta 10 -0.0584642
ANGPTL4 angiopoietin-like 4 -0.0584287
ZBTB20 zinc finger and BTB domain containing 20 -0.0572306
CD44 CD44 molecule (Indian blood group) -0.0547714
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0538789
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0531167
NALCN sodium leak channel, non selective -0.0502713
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.050153
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0490239
PRSS23 protease, serine, 23 -0.0485561
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0476165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0463817
POTEF POTE ankyrin domain family, member F -0.0461177
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0444923
TPT1 tumor protein, translationally-controlled 1 -0.0436614
RAI14 retinoic acid induced 14 -0.0435014
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0423125
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0417243
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0407054
FMNL2 formin-like 2 -0.0406345
SVIL supervillin -0.0403009
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0400696
NPAS2 neuronal PAS domain protein 2 -0.0399207
PRR16 proline rich 16 -0.0393567
NT5E 5'-nucleotidase, ecto (CD73) -0.0387925
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0387384
THSD4 thrombospondin, type I, domain containing 4 -0.0385382
DPYD dihydropyrimidine dehydrogenase -0.0383522
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0382273
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0381971
OSMR oncostatin M receptor -0.0375713
AKAP13 A kinase (PRKA) anchor protein 13 -0.0371944
PCED1B PC-esterase domain containing 1B -0.0365099
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0353477
LDHA lactate dehydrogenase A -0.0345343
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0342478
PARD3 par-3 family cell polarity regulator -0.0337537
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0335909
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0333291
FTH1 ferritin, heavy polypeptide 1 -0.0333175
TIMP1 TIMP metallopeptidase inhibitor 1 -0.032756
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0320508
FMN1 formin 1 -0.0316206
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.029943
PLEK2 pleckstrin 2 -0.0293239
PTPRG protein tyrosine phosphatase, receptor type, G -0.0292123
SLC38A2 solute carrier family 38, member 2 -0.0283054
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0281252
NAV3 neuron navigator 3 -0.028119
PODXL podocalyxin-like -0.028108
EGFR epidermal growth factor receptor -0.0280123
RAD51B RAD51 paralog B -0.0278881
EFNA5 ephrin-A5 -0.0278519
PTK2 protein tyrosine kinase 2 -0.0272001
FLNB filamin B, beta -0.0266785
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0261484
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.02607
NDRG1 N-myc downstream regulated 1 -0.0259387
ZFHX3 zinc finger homeobox 3 -0.0256711
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0254949
BTBD9 BTB (POZ) domain containing 9 -0.0248606
RSAD2 radical S-adenosyl methionine domain containing 2 -0.024812
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0246585
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0245152
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0242208
SDCCAG8 serologically defined colon cancer antigen 8 -0.0239917
ENO2 enolase 2 (gamma, neuronal) -0.023506
LOC112694756 uncharaterized LOC112694756 -0.0235048
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0233691
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0233665
ZMYND8 zinc finger, MYND-type containing 8 -0.0229522
LAMA5 laminin, alpha 5 -0.0229055
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0229025
AEBP2 AE binding protein 2 -0.0227293
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0225925
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0224541
SH3KBP1 SH3-domain kinase binding protein 1 -0.0222013
WARS1 tryptophanyl-tRNA synthetase 1 -0.022147
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0220363
FAM3C family with sequence similarity 3, member C -0.0219736
ATXN1 ataxin 1 -0.0219518
TMEM14B transmembrane protein 14B -0.0218571
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0209856
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0208606
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0206979
MACF1 microtubule-actin crosslinking factor 1 -0.0203269
CDCP1 CUB domain containing protein 1 -0.0202614
UNC13A unc-13 homolog A (C. elegans) -0.020106
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0200456
ITGB4 integrin, beta 4 -0.0196644
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0195764
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0194365
ACER3 alkaline ceramidase 3 -0.0192279
KIAA1671 KIAA1671 -0.0191615