14-3-3 protein binding Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. (Gene Ontology, GO_0071889)
External Link http://amigo.geneontology.org/amigo/term/GO:0071889
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16 genes performing the 14-3-3 protein binding molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARRB2 arrestin, beta 2
DAB2IP DAB2 interacting protein
DDIT4 DNA-damage-inducible transcript 4
HDAC7 histone deacetylase 7
IRS2 insulin receptor substrate 2
KIF13B kinesin family member 13B
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
RPTOR regulatory associated protein of MTOR, complex 1
SRPK2 SRSF protein kinase 2
SYNPO2 synaptopodin 2
TSC2 tuberous sclerosis 2
ZFP36 ZFP36 ring finger protein