18β-Glycyrrhetinic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.260547
AKAP12 A kinase (PRKA) anchor protein 12 0.164037
NDRG1 N-myc downstream regulated 1 0.125394
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.109593
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.10886
TMSB10 thymosin beta 10 0.101245
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0844888
PODXL podocalyxin-like 0.0806477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0792633
LDHA lactate dehydrogenase A 0.0784808
LOX lysyl oxidase 0.0752315
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0730345
CD44 CD44 molecule (Indian blood group) 0.0728608
B2M beta-2-microglobulin 0.0704413
FLNB filamin B, beta 0.0700467
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0664481
KLF6 Kruppel-like factor 6 0.0584425
STC1 stanniocalcin 1 0.0560833
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0548011
RPL23 ribosomal protein L23 0.0516216
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0502092
HLA-A major histocompatibility complex, class I, A 0.0479657
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0474235
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0462705
EFNA5 ephrin-A5 0.0454642
EGFR epidermal growth factor receptor 0.04467
IFITM3 interferon induced transmembrane protein 3 0.0422757
RPS19 ribosomal protein S19 0.0419826
RPS3 ribosomal protein S3 0.0412859
LGALS1 lectin, galactoside-binding, soluble, 1 0.0412172
EIF1 eukaryotic translation initiation factor 1 0.0407944
RPS6 ribosomal protein S6 0.0402285
EZR ezrin 0.040157
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0401569
RACK1 receptor for activated C kinase 1 0.0398034
MSN moesin 0.0397605
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0375455
SFTPA2 surfactant protein A2 0.03568
TAGLN2 transgelin 2 0.034589
EEF2 eukaryotic translation elongation factor 2 0.0343226
RUNX1 runt-related transcription factor 1 0.0342749
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.034244
S100A11 S100 calcium binding protein A11 0.0342345
RPL36 ribosomal protein L36 0.0340682
C1D C1D nuclear receptor corepressor 0.0340147
LOC112694756 uncharaterized LOC112694756 0.0339368
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0330144
RPS12 ribosomal protein S12 0.0324101
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0323862
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0322131
TPI1 triosephosphate isomerase 1 0.0319969
RPL12 ribosomal protein L12 0.0319366
ATP13A3 ATPase type 13A3 0.030851
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0305292
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0305088
CSTB cystatin B (stefin B) 0.0301626
SMAD3 SMAD family member 3 0.0300222
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0298264
FTH1 ferritin, heavy polypeptide 1 0.0295468
ANKRD11 ankyrin repeat domain 11 0.0287956
ENO1 enolase 1, (alpha) 0.0287754
NAV2 neuron navigator 2 0.0287724
AFDN afadin, adherens junction formation factor 0.0285046
DOCK5 dedicator of cytokinesis 5 0.0284192
HDAC9 histone deacetylase 9 0.0283656
ENO2 enolase 2 (gamma, neuronal) 0.0283102
FTL ferritin, light polypeptide 0.028152
RPS27 ribosomal protein S27 0.0279548
PSD3 pleckstrin and Sec7 domain containing 3 0.0277468
AKAP9 A kinase (PRKA) anchor protein 9 0.0277108
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0272302
RPL37A ribosomal protein L37a 0.0271775
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0270441
FNDC3B fibronectin type III domain containing 3B 0.0268892
CBX3 chromobox homolog 3 0.0264771
SERINC1 serine incorporator 1 0.0261731
GLIS3 GLIS family zinc finger 3 0.0257473
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0252676
RPL31 ribosomal protein L31 0.0252407
ERBIN erbb2 interacting protein 0.0251127
SEPTIN9 septin 9 0.0250568
SRRM2 serine/arginine repetitive matrix 2 0.0250165
PKM pyruvate kinase, muscle 0.0249136
TUBB4B tubulin, beta 4B class IVb 0.0248587
AHNAK2 AHNAK nucleoprotein 2 0.0246564
PCBP2 poly(rC) binding protein 2 0.0245476
MCFD2 multiple coagulation factor deficiency 2 0.0241829
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0240879
PRELID2 PRELI domain containing 2 0.0239522
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0239074
TIMP2 TIMP metallopeptidase inhibitor 2 0.0238366
RAI1 retinoic acid induced 1 0.0237716
RPS17 ribosomal protein S17 0.023389
PTBP3 polypyrimidine tract binding protein 3 0.0233885
NOTCH2 notch 2 0.0233667
SQSTM1 sequestosome 1 0.0231977
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0230032
FLNA filamin A, alpha 0.0229983
RPL26 ribosomal protein L26 0.0228638
SON SON DNA binding protein 0.0225682

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.169269
ABI3BP ABI family, member 3 (NESH) binding protein -0.153116
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.123602
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.114084
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.110886
IGFBP3 insulin-like growth factor binding protein 3 -0.103855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.101117
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.100929
COL5A1 collagen, type V, alpha 1 -0.0938279
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0904458
S100A10 S100 calcium binding protein A10 -0.0862488
RIGI RNA sensor RIG-I -0.0857954
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0854222
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0850677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0841843
MAP1B microtubule-associated protein 1B -0.083133
SUCNR1 succinate receptor 1 -0.0801259
SAMD9 sterile alpha motif domain containing 9 -0.0785102
NAV1 neuron navigator 1 -0.0733842
LMNA lamin A/C -0.0715448
SLC39A11 solute carrier family 39, member 11 -0.0689436
SLC38A1 solute carrier family 38, member 1 -0.0685253
MX2 MX dynamin-like GTPase 2 -0.0681532
S100A6 S100 calcium binding protein A6 -0.0607727
COL1A2 collagen, type I, alpha 2 -0.0594967
SORBS2 sorbin and SH3 domain containing 2 -0.0583008
HLA-B major histocompatibility complex, class I, B -0.0574126
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0569928
CUX1 cut-like homeobox 1 -0.0558736
IL7R interleukin 7 receptor -0.0536252
SPAG9 sperm associated antigen 9 -0.0519651
KRT81 keratin 81, type II -0.0513545
LRRC17 leucine rich repeat containing 17 -0.0503586
CANX calnexin -0.0490988
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0488296
PRSS23 protease, serine, 23 -0.0481924
OASL 2'-5'-oligoadenylate synthetase-like -0.047946
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0477313
TPM1 tropomyosin 1 (alpha) -0.0475525
MSI2 musashi RNA-binding protein 2 -0.0472596
MEIS2 Meis homeobox 2 -0.0471179
COL1A1 collagen, type I, alpha 1 -0.0460429
IFIH1 interferon induced with helicase C domain 1 -0.0440129
S100A4 S100 calcium binding protein A4 -0.0438183
WARS1 tryptophanyl-tRNA synthetase 1 -0.0422929
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0419262
PTMA prothymosin, alpha -0.0402511
TNS3 tensin 3 -0.0375481
COL3A1 collagen, type III, alpha 1 -0.0373218
SH3KBP1 SH3-domain kinase binding protein 1 -0.0367489
FNDC3A fibronectin type III domain containing 3A -0.0362551
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.035572
HLA-C major histocompatibility complex, class I, C -0.0351459
VIM vimentin -0.0348885
IFI16 interferon, gamma-inducible protein 16 -0.0347318
COL5A2 collagen, type V, alpha 2 -0.0335819
PLXNA2 plexin A2 -0.0335673
ACTG1 actin gamma 1 -0.0323453
GNAS GNAS complex locus -0.0320421
SAMD9L sterile alpha motif domain containing 9-like -0.031822
CCND1 cyclin D1 -0.0316617
MED13L mediator complex subunit 13-like -0.0312915
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0312385
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0311203
FLT1 fms-related tyrosine kinase 1 -0.0304484
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0304371
CDH13 cadherin 13 -0.0301573
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0301057
TPM4 tropomyosin 4 -0.0292081
CKAP4 cytoskeleton-associated protein 4 -0.0291632
DLG1 discs, large homolog 1 (Drosophila) -0.0289736
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0286546
TMSB4X thymosin beta 4, X-linked -0.0284731
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0283804
COPA coatomer protein complex, subunit alpha -0.0275095
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0267538
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0266445
SRPK2 SRSF protein kinase 2 -0.0261228
KPNB1 karyopherin (importin) beta 1 -0.0259509
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0257927
NPR2 natriuretic peptide receptor 2 -0.0255974
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0253848
ZMYND8 zinc finger, MYND-type containing 8 -0.0253843
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.025296
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0252334
RAB1A RAB1A, member RAS oncogene family -0.0250049
CYTH3 cytohesin 3 -0.0242991
ZNFX1 zinc finger, NFX1-type containing 1 -0.0240691
SAR1A secretion associated, Ras related GTPase 1A -0.0239906
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0236528
IGFBP6 insulin-like growth factor binding protein 6 -0.0236141
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0231815
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0227154
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0224717
TUBB tubulin, beta class I -0.022356
HMGB1 high mobility group box 1 -0.0221642
H3-3B H3.3 histone B -0.0220972
LY6E lymphocyte antigen 6 complex, locus E -0.0217201
COL8A1 collagen, type VIII, alpha 1 -0.0214641
FGF13 fibroblast growth factor 13 -0.021324