18β-Glycyrrhetinic acid_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.260639
AREG amphiregulin 0.137988
TMSB10 thymosin beta 10 0.127643
TPI1 triosephosphate isomerase 1 0.120505
PCDH7 protocadherin 7 0.105086
RPS12 ribosomal protein S12 0.104346
RPS3 ribosomal protein S3 0.0943704
FTL ferritin, light polypeptide 0.0840574
ANXA1 annexin A1 0.0678744
RPL23 ribosomal protein L23 0.0677036
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0618339
RPL37A ribosomal protein L37a 0.0610914
RPL12 ribosomal protein L12 0.0605185
VIM vimentin 0.0563305
RPL36 ribosomal protein L36 0.055484
RPS27 ribosomal protein S27 0.0538629
MARCHF4 membrane associated ring-CH-type finger 4 0.0520611
RPS26 ribosomal protein S26 0.0511811
HLA-A major histocompatibility complex, class I, A 0.0503662
LDHA lactate dehydrogenase A 0.0487911
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0467315
RPL37 ribosomal protein L37 0.0466326
GARS1 glycyl-tRNA synthetase 1 0.0428048
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0420287
ANKRD12 ankyrin repeat domain 12 0.0411208
RPL9 ribosomal protein L9 0.0407734
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0400971
CNRIP1 cannabinoid receptor interacting protein 1 0.0391061
EZR ezrin 0.037869
RPS17 ribosomal protein S17 0.0373505
RPS6 ribosomal protein S6 0.0371105
RPL18 ribosomal protein L18 0.036857
CCN2 cellular communication network factor 2 0.036674
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0360485
CCDC88A coiled-coil domain containing 88A 0.0360233
RPS19 ribosomal protein S19 0.0357407
YBX3 Y box binding protein 3 0.035645
PRDX1 peroxiredoxin 1 0.0342288
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0334327
NEBL nebulette 0.0325455
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0323489
NACA nascent polypeptide-associated complex alpha subunit 0.0311597
CCSER1 coiled-coil serine-rich protein 1 0.0302712
NARS1 asparaginyl-tRNA synthetase 1 0.0299233
GJA1 gap junction protein, alpha 1, 43kDa 0.029808
LOC102724023 ES1 protein homolog, mitochondrial 0.0296689
ATP5F1E ATP synthase F1 subunit epsilon 0.0296205
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0294819
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0294337
RPS7 ribosomal protein S7 0.0289051
RPL10A ribosomal protein L10a 0.0285751
POTEF POTE ankyrin domain family, member F 0.02844
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0274057
SRRM2 serine/arginine repetitive matrix 2 0.0272016
EDN1 endothelin 1 0.0268771
PDE4D phosphodiesterase 4D, cAMP-specific 0.0267817
RIMS2 regulating synaptic membrane exocytosis 2 0.0267193
RABGAP1L RAB GTPase activating protein 1-like 0.0264998
EGFR epidermal growth factor receptor 0.0264916
RACK1 receptor for activated C kinase 1 0.0263495
PDGFC platelet derived growth factor C 0.0263476
MAP1B microtubule-associated protein 1B 0.0262012
HSPE1 heat shock 10kDa protein 1 0.0259674
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0256239
TMEM41B transmembrane protein 41B 0.0255845
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0253971
B2M beta-2-microglobulin 0.0247046
RPL21 ribosomal protein L21 0.0246041
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0242567
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0240431
PGK1 phosphoglycerate kinase 1 0.0235962
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0234294
LDHB lactate dehydrogenase B 0.0232778
MRPL33 mitochondrial ribosomal protein L33 0.023121
UQCRB ubiquinol-cytochrome c reductase binding protein 0.022899
FOXM1 forkhead box M1 0.0222026
EEF1G eukaryotic translation elongation factor 1 gamma 0.0221587
NCEH1 neutral cholesterol ester hydrolase 1 0.022
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 0.0219965
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.0218453
NDUFA4 NDUFA4, mitochondrial complex associated 0.0217191
RPS2 ribosomal protein S2 0.0214646
BIRC3 baculoviral IAP repeat containing 3 0.0212179
KTN1 kinectin 1 (kinesin receptor) 0.0210472
RPL11 ribosomal protein L11 0.021029
NAMPT nicotinamide phosphoribosyltransferase 0.0207231
RTN4 reticulon 4 0.0206336
NLGN1 neuroligin 1 0.0206134
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0205919
TUBB4B tubulin, beta 4B class IVb 0.0203917
SF3B6 splicing factor 3b, subunit 6, 14kDa 0.0203701
NUCB2 nucleobindin 2 0.0202462
IPO7 importin 7 0.0201733
PPID peptidylprolyl isomerase D 0.0200293
KDM5A lysine (K)-specific demethylase 5A 0.0196099
WSB1 WD repeat and SOCS box containing 1 0.0196089
CSNK1A1 casein kinase 1, alpha 1 0.0195335
RPL26 ribosomal protein L26 0.0194788
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.019467
SERINC1 serine incorporator 1 0.0191769

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.279896
ACTG1 actin gamma 1 -0.16914
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.1299
PTMA prothymosin, alpha -0.113418
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0857704
RAB7A RAB7A, member RAS oncogene family -0.0843551
TPT1 tumor protein, translationally-controlled 1 -0.0790565
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0758132
IFIH1 interferon induced with helicase C domain 1 -0.0654338
MYL12B myosin, light chain 12B, regulatory -0.0642453
USP34 ubiquitin specific peptidase 34 -0.0637252
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0621357
MMP12 matrix metallopeptidase 12 -0.0590665
TMEM123 transmembrane protein 123 -0.0590454
CANX calnexin -0.0578841
TAS2R14 taste receptor, type 2, member 14 -0.0547977
FUS FUS RNA binding protein -0.0515558
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0490233
UBC ubiquitin C -0.0486765
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0485535
MED13L mediator complex subunit 13-like -0.0484214
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0477065
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0472268
VDAC1 voltage-dependent anion channel 1 -0.0444117
RPL34 ribosomal protein L34 -0.0437298
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0436174
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0435979
H1-0 H1.0 linker histone -0.043247
KPNB1 karyopherin (importin) beta 1 -0.0430595
ZNF804A zinc finger protein 804A -0.0429945
AHNAK AHNAK nucleoprotein -0.0428337
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0425024
TM4SF1 transmembrane 4 L six family member 1 -0.0418002
CDK12 cyclin-dependent kinase 12 -0.0416498
KDM3A lysine (K)-specific demethylase 3A -0.0412807
VMP1 vacuole membrane protein 1 -0.0403513
RSL1D1 ribosomal L1 domain containing 1 -0.040316
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0399636
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0394374
S100A10 S100 calcium binding protein A10 -0.038173
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0374399
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0373926
RAB10 RAB10, member RAS oncogene family -0.0371892
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0370796
EHBP1 EH domain binding protein 1 -0.0366846
TUBB tubulin, beta class I -0.0364293
RAB1A RAB1A, member RAS oncogene family -0.0362818
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0361104
TUBA1C tubulin, alpha 1c -0.0353796
NF1 neurofibromin 1 -0.0351667
ZFAND3 zinc finger, AN1-type domain 3 -0.035052
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0347157
KHSRP KH-type splicing regulatory protein -0.0347153
RPS21 ribosomal protein S21 -0.0345652
FBXO11 F-box protein 11 -0.0341446
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0340357
NSD2 nuclear receptor binding SET domain protein 2 -0.033821
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.033568
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0333409
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0329723
RPL8 ribosomal protein L8 -0.0327696
HMGA2 high mobility group AT-hook 2 -0.0326974
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0319124
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0318269
GSK3B glycogen synthase kinase 3 beta -0.031652
MKI67 marker of proliferation Ki-67 -0.0310883
BIRC6 baculoviral IAP repeat containing 6 -0.0305607
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0304717
ATP5F1B ATP synthase F1 subunit beta -0.0303389
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0302631
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.030113
SPDYA speedy/RINGO cell cycle regulator family member A -0.0300429
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0296765
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0295914
KCMF1 potassium channel modulatory factor 1 -0.029494
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0294483
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0292762
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0290471
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0289716
HMGA1 high mobility group AT-hook 1 -0.0288927
NABP1 nucleic acid binding protein 1 -0.0288466
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0287903
TUBA1B tubulin, alpha 1b -0.0286122
GNAS GNAS complex locus -0.0285707
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0284881
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0280585
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0279995
MARCHF6 membrane associated ring-CH-type finger 6 -0.027286
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0266764
SNX14 sorting nexin 14 -0.0266506
RBMX RNA binding motif protein, X-linked -0.0266358
SLC38A1 solute carrier family 38, member 1 -0.026558
SPAG9 sperm associated antigen 9 -0.0264465
ZNF207 zinc finger protein 207 -0.0263008
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0261314
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0260033
RPS27A ribosomal protein S27a -0.0257448
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0255627
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0255007
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0251172