18β-Glycyrrhetinic acid_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.172832
VIM vimentin 0.152611
TMSB10 thymosin beta 10 0.131637
B2M beta-2-microglobulin 0.121742
FTL ferritin, light polypeptide 0.0963811
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0872121
TPT1 tumor protein, translationally-controlled 1 0.0760816
HLA-B major histocompatibility complex, class I, B 0.0747289
CD44 CD44 molecule (Indian blood group) 0.0738365
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0721085
IGFBP3 insulin-like growth factor binding protein 3 0.0653303
MT2A metallothionein 2A 0.064022
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.061568
EXT1 exostosin glycosyltransferase 1 0.0599394
RPL37A ribosomal protein L37a 0.0567012
CALU calumenin 0.0511604
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0499454
RND3 Rho family GTPase 3 0.0488257
HLA-A major histocompatibility complex, class I, A 0.0487202
AKAP9 A kinase (PRKA) anchor protein 9 0.0486492
ZSWIM6 zinc finger, SWIM-type containing 6 0.047327
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0469916
RAI14 retinoic acid induced 14 0.0459212
RPL23 ribosomal protein L23 0.0454062
RPL26 ribosomal protein L26 0.0449058
RACK1 receptor for activated C kinase 1 0.0444844
RPS19 ribosomal protein S19 0.0438952
RPL31 ribosomal protein L31 0.0420013
EIF1 eukaryotic translation initiation factor 1 0.0418578
RPS8 ribosomal protein S8 0.041677
RPL34 ribosomal protein L34 0.0414338
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0409337
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0406882
RPL12 ribosomal protein L12 0.0403168
RPS27A ribosomal protein S27a 0.0401581
HM13 histocompatibility (minor) 13 0.0393992
RPL19 ribosomal protein L19 0.0393075
ASPH aspartate beta-hydroxylase 0.0387841
RPL35A ribosomal protein L35a 0.0369753
RPS3 ribosomal protein S3 0.0365851
LMNA lamin A/C 0.0362791
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0361936
RPL37 ribosomal protein L37 0.0360595
NAV2 neuron navigator 2 0.0357333
PALM2AKAP2 PALM2 and AKAP2 fusion 0.035604
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0354582
IFITM3 interferon induced transmembrane protein 3 0.0354139
ARL4C ADP-ribosylation factor-like 4C 0.0352672
TTC3 tetratricopeptide repeat domain 3 0.0345967
RPS24 ribosomal protein S24 0.0345645
IFI6 interferon, alpha-inducible protein 6 0.0338537
GOLGB1 golgin B1 0.0337628
RPS17 ribosomal protein S17 0.0335861
HLA-C major histocompatibility complex, class I, C 0.0335697
KYNU kynureninase 0.0331505
RPL27 ribosomal protein L27 0.0331238
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0329518
CALR calreticulin 0.0329343
EHBP1 EH domain binding protein 1 0.0327374
SFTPA2 surfactant protein A2 0.0324649
PLIN2 perilipin 2 0.0320894
CTSD cathepsin D 0.0317986
RPS21 ribosomal protein S21 0.031713
EXOC4 exocyst complex component 4 0.0316109
IFI44L interferon-induced protein 44-like 0.0315345
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0315055
LOC112694756 uncharaterized LOC112694756 0.0307023
RPL9 ribosomal protein L9 0.0303723
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303709
CD63 CD63 molecule 0.0298661
APOL1 apolipoprotein L, 1 0.0298241
SP100 SP100 nuclear antigen 0.0293174
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0292256
LYST lysosomal trafficking regulator 0.0290306
RPL11 ribosomal protein L11 0.0288938
IFI27 interferon, alpha-inducible protein 27 0.0286
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0281852
TUBB4B tubulin, beta 4B class IVb 0.0280249
CSNK1A1 casein kinase 1, alpha 1 0.0279543
LDHA lactate dehydrogenase A 0.0277727
INTS6 integrator complex subunit 6 0.0276524
FAM107B family with sequence similarity 107, member B 0.0274636
RPS4X ribosomal protein S4, X-linked 0.0271953
RPS12 ribosomal protein S12 0.0270732
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0270668
RRBP1 ribosome binding protein 1 0.0269173
ACTG1 actin gamma 1 0.0267116
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0266112
ZBTB20 zinc finger and BTB domain containing 20 0.0265373
RSL1D1 ribosomal L1 domain containing 1 0.026303
HDAC9 histone deacetylase 9 0.0263002
GLIS3 GLIS family zinc finger 3 0.0262842
RPL28 ribosomal protein L28 0.0259897
BLZF1 basic leucine zipper nuclear factor 1 0.0257468
RPS13 ribosomal protein S13 0.0256763
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0253926
MYO1E myosin IE 0.0253875
CAVIN1 caveolae associated protein 1 0.0252159
RPL7A ribosomal protein L7a 0.0249948
DOCK5 dedicator of cytokinesis 5 0.0244448

decreased expression

Symbol Name Standardized Value
CSF1 colony stimulating factor 1 (macrophage) -0.109638
GLS2 glutaminase 2 (liver, mitochondrial) -0.0891027
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0811842
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0738722
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0615366
SPAG9 sperm associated antigen 9 -0.0610447
ANKRD33B ankyrin repeat domain 33B -0.0579799
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0547027
OSBPL3 oxysterol binding protein-like 3 -0.0545085
CCL2 chemokine (C-C motif) ligand 2 -0.0542443
DENND2B DENN domain containing 2B -0.0534736
CADM1 cell adhesion molecule 1 -0.0530463
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0526957
UGCG UDP-glucose ceramide glucosyltransferase -0.052249
NRIP1 nuclear receptor interacting protein 1 -0.05137
ADAM9 ADAM metallopeptidase domain 9 -0.0512069
PTBP3 polypyrimidine tract binding protein 3 -0.0483519
SOD2 superoxide dismutase 2, mitochondrial -0.0477712
KMT2E lysine (K)-specific methyltransferase 2E -0.0456573
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0439943
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0435413
MARCHF6 membrane associated ring-CH-type finger 6 -0.0427032
ADAM17 ADAM metallopeptidase domain 17 -0.0425229
RTN4 reticulon 4 -0.0405745
ANKRD10 ankyrin repeat domain 10 -0.0401257
USP3 ubiquitin specific peptidase 3 -0.0395234
PTPRJ protein tyrosine phosphatase, receptor type, J -0.038251
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0379568
WAC WW domain containing adaptor with coiled-coil -0.0374122
XPO1 exportin 1 -0.0372643
FNDC3B fibronectin type III domain containing 3B -0.0369294
G0S2 G0/G1 switch 2 -0.0363268
RUNX1 runt-related transcription factor 1 -0.0362084
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0362056
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0358254
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0356592
ARHGAP26 Rho GTPase activating protein 26 -0.0344617
VCAM1 vascular cell adhesion molecule 1 -0.0341397
SP3 Sp3 transcription factor -0.0340963
SRPK2 SRSF protein kinase 2 -0.0334248
DDIT4 DNA-damage-inducible transcript 4 -0.0333847
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0325326
SBF2 SET binding factor 2 -0.0321571
MYH9 myosin, heavy chain 9, non-muscle -0.0320099
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0319766
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.03185
ITGAV integrin, alpha V -0.0315856
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0315312
SLMAP sarcolemma associated protein -0.0315059
QKI QKI, KH domain containing, RNA binding -0.0308089
INSIG1 insulin induced gene 1 -0.0307692
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0307058
KDM6A lysine (K)-specific demethylase 6A -0.0306115
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0305897
RBM39 RNA binding motif protein 39 -0.030366
FMNL2 formin-like 2 -0.0302142
CCNL1 cyclin L1 -0.029822
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0294536
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0291765
EML4 echinoderm microtubule associated protein like 4 -0.029011
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0288932
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0286597
ICAM1 intercellular adhesion molecule 1 -0.0285022
ANXA5 annexin A5 -0.0283968
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0281163
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0280438
PLPP3 phospholipid phosphatase 3 -0.0280352
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0279003
ACBD3 acyl-CoA binding domain containing 3 -0.0278085
TFG TRK-fused gene -0.0277189
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0276494
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0275389
ECPAS Ecm29 proteasome adaptor and scaffold -0.0273829
BIRC3 baculoviral IAP repeat containing 3 -0.0272407
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0271397
AZIN1 antizyme inhibitor 1 -0.0270973
AFTPH aftiphilin -0.0270459
ANLN anillin, actin binding protein -0.026816
NRP2 neuropilin 2 -0.0267519
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0266379
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0266139
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0266047
MYO1B myosin IB -0.0265816
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0264318
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0263304
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0261588
MATR3 matrin 3 -0.0261041
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0260912
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0259387
PRRC1 proline-rich coiled-coil 1 -0.0258721
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0256638
RAP1B RAP1B, member of RAS oncogene family -0.0254006
LCOR ligand dependent nuclear receptor corepressor -0.0253566
RNF145 ring finger protein 145 -0.0252867
STOM stomatin -0.0252212
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0250381
SETD5 SET domain containing 5 -0.0250125
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0249829
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0248085
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0247239