18β-Glycyrrhetinic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.215763
NDRG1 N-myc downstream regulated 1 0.171197
AKAP12 A kinase (PRKA) anchor protein 12 0.118521
TMSB10 thymosin beta 10 0.108131
EFNA5 ephrin-A5 0.0950153
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0795115
FLNB filamin B, beta 0.0754343
EZR ezrin 0.0746239
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0727997
ITPRID2 ITPR interacting domain containing 2 0.0682992
RPL12 ribosomal protein L12 0.0667119
RPS3 ribosomal protein S3 0.0620308
EIF1 eukaryotic translation initiation factor 1 0.0618714
LAMC2 laminin, gamma 2 0.060872
KLF6 Kruppel-like factor 6 0.0606271
ARHGAP42 Rho GTPase activating protein 42 0.05914
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0558375
TPT1 tumor protein, translationally-controlled 1 0.0554709
RPL37A ribosomal protein L37a 0.0537023
RPL23 ribosomal protein L23 0.0530712
EGFR epidermal growth factor receptor 0.0509334
SACK1A scaffolding CK1 anchoring protein A 0.0495334
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0485553
VIM vimentin 0.0482258
ZSWIM6 zinc finger, SWIM-type containing 6 0.0471185
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0458788
LAMA4 laminin, alpha 4 0.0458574
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0448189
MT2A metallothionein 2A 0.042769
LDHA lactate dehydrogenase A 0.0425325
RPS12 ribosomal protein S12 0.0424723
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0424072
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0423158
RPS19 ribosomal protein S19 0.0422436
RPL11 ribosomal protein L11 0.0414668
PTPRF protein tyrosine phosphatase, receptor type, F 0.0410491
ERBIN erbb2 interacting protein 0.040407
FTL ferritin, light polypeptide 0.0384963
SGMS2 sphingomyelin synthase 2 0.0378308
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0377151
POTEF POTE ankyrin domain family, member F 0.0373258
VMP1 vacuole membrane protein 1 0.0362947
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.036054
MBNL1 muscleblind-like splicing regulator 1 0.0357232
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0355751
AREG amphiregulin 0.0349999
WWC1 WW and C2 domain containing 1 0.0347216
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0346157
TJP1 tight junction protein 1 0.0341153
RPL9 ribosomal protein L9 0.0327894
RPL37 ribosomal protein L37 0.0316468
CD44 CD44 molecule (Indian blood group) 0.0313282
CAPN2 calpain 2, (m/II) large subunit 0.0309114
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.030493
MAPK8 mitogen-activated protein kinase 8 0.0303213
PSD3 pleckstrin and Sec7 domain containing 3 0.0294421
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0294269
SEPTIN9 septin 9 0.029061
CAB39 calcium binding protein 39 0.0290563
RPL36 ribosomal protein L36 0.0290347
SERINC1 serine incorporator 1 0.028993
SMAD3 SMAD family member 3 0.0287682
TRIO trio Rho guanine nucleotide exchange factor 0.0287533
RPL26 ribosomal protein L26 0.0287269
AHNAK2 AHNAK nucleoprotein 2 0.0286803
BMAL2 basic helix-loop-helix ARNT like 2 0.0285633
GDA guanine deaminase 0.0283071
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0282559
NAP1L1 nucleosome assembly protein 1-like 1 0.0281953
RPS14 ribosomal protein S14 0.0278417
S100A11 S100 calcium binding protein A11 0.0276382
RPS24 ribosomal protein S24 0.0276081
DSPP dentin sialophosphoprotein 0.0271976
RAB2A RAB2A, member RAS oncogene family 0.0271582
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0268649
RPLP2 ribosomal protein, large, P2 0.0263517
RACK1 receptor for activated C kinase 1 0.0261354
RPS8 ribosomal protein S8 0.0260707
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259134
ENO1 enolase 1, (alpha) 0.0255394
PMM2 phosphomannomutase 2 0.025369
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0250263
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0248571
HSPA8 heat shock 70kDa protein 8 0.0248203
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0246611
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0246258
RASAL2 RAS protein activator like 2 0.0245824
RPL31 ribosomal protein L31 0.0237285
SRRM2 serine/arginine repetitive matrix 2 0.0236622
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0236526
STC1 stanniocalcin 1 0.0235895
HDAC9 histone deacetylase 9 0.0233718
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0233197
NACA nascent polypeptide-associated complex alpha subunit 0.0231627
PRRC2C proline-rich coiled-coil 2C 0.0230172
BCAR3 breast cancer anti-estrogen resistance 3 0.0226641
DUSP4 dual specificity phosphatase 4 0.0226286
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0225472
CARHSP1 calcium regulated heat stable protein 1, 24kDa 0.0218119
ATG12 autophagy related 12 0.0216235

decreased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.226786
FTH1 ferritin, heavy polypeptide 1 -0.118548
BAIAP2L1 BAI1-associated protein 2-like 1 -0.103798
IGFBP3 insulin-like growth factor binding protein 3 -0.0960244
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0951023
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0929207
F3 coagulation factor III (thromboplastin, tissue factor) -0.0902324
VCAN versican -0.0731658
SKAP2 src kinase associated phosphoprotein 2 -0.072781
PTMA prothymosin, alpha -0.0702773
LMTK2 lemur tyrosine kinase 2 -0.0702524
ANTXR2 anthrax toxin receptor 2 -0.0692751
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0692578
TPM4 tropomyosin 4 -0.0686211
CLMP CXADR-like membrane protein -0.0666768
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0656058
LMO7 LIM domain 7 -0.0604894
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0603253
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0592786
FAM3C family with sequence similarity 3, member C -0.0592319
PARD3 par-3 family cell polarity regulator -0.0578928
ARF4 ADP-ribosylation factor 4 -0.056516
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0557662
MXD1 MAX dimerization protein 1 -0.0555063
TRRAP transformation/transcription domain-associated protein -0.0550653
SMC3 structural maintenance of chromosomes 3 -0.0549973
UBE2H ubiquitin-conjugating enzyme E2H -0.0540766
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0521544
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0517246
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0516499
MAML2 mastermind-like 2 (Drosophila) -0.051457
SPAG9 sperm associated antigen 9 -0.0509216
PRSS3 protease, serine, 3 -0.0505582
ADAM9 ADAM metallopeptidase domain 9 -0.0492521
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.048542
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0465724
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0464615
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0452297
RAB1A RAB1A, member RAS oncogene family -0.0446707
BIRC6 baculoviral IAP repeat containing 6 -0.0446196
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0437018
TPM3 tropomyosin 3 -0.0432151
LY6E lymphocyte antigen 6 complex, locus E -0.0425941
SLMAP sarcolemma associated protein -0.0425158
ZMYND8 zinc finger, MYND-type containing 8 -0.0419533
RABGAP1L RAB GTPase activating protein 1-like -0.0419504
ESYT2 extended synaptotagmin-like protein 2 -0.0413246
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0408151
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.040728
MCL1 myeloid cell leukemia 1 -0.0402577
RIOK3 RIO kinase 3 -0.0398644
GREB1L growth regulation by estrogen in breast cancer-like -0.0393795
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0391654
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0386065
CD2AP CD2-associated protein -0.0381179
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0369378
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0369325
PTK2 protein tyrosine kinase 2 -0.0367879
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0367436
AK1 adenylate kinase 1 -0.0359705
SEC31A SEC31 homolog A (S. cerevisiae) -0.0359202
UPP1 uridine phosphorylase 1 -0.0352113
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.0350359
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0349992
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0346948
HMGA1 high mobility group AT-hook 1 -0.034685
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0343991
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0336057
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0334164
ITCH itchy E3 ubiquitin protein ligase -0.0333162
KDM2A lysine (K)-specific demethylase 2A -0.0332402
TXNIP thioredoxin interacting protein -0.0331951
ABHD3 abhydrolase domain containing 3 -0.0331941
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0327536
COPA coatomer protein complex, subunit alpha -0.0325305
DIAPH2 diaphanous-related formin 2 -0.0322909
WASF2 WAS protein family, member 2 -0.0316993
KCMF1 potassium channel modulatory factor 1 -0.0316101
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0314856
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0312972
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0311032
ADAM17 ADAM metallopeptidase domain 17 -0.030978
KDM5B lysine (K)-specific demethylase 5B -0.0309125
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0306413
NT5C2 5'-nucleotidase, cytosolic II -0.0302987
RNF213 ring finger protein 213 -0.0300979
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0300939
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.029912
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0292824
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.029216
FERMT1 fermitin family member 1 -0.0291411
LUC7L LUC7-like (S. cerevisiae) -0.0289839
FNBP4 formin binding protein 4 -0.0287978
RAP1B RAP1B, member of RAS oncogene family -0.0286766
PDE4D phosphodiesterase 4D, cAMP-specific -0.0285759
COL17A1 collagen, type XVII, alpha 1 -0.0280536
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0278045
MCU mitochondrial calcium uniporter -0.0277739
SBF2 SET binding factor 2 -0.0277008
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0273485