18β-Glycyrrhetinic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.193755
RPS12 ribosomal protein S12 0.108209
RPL23 ribosomal protein L23 0.0867247
RPS3 ribosomal protein S3 0.0835078
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0723562
RPL37A ribosomal protein L37a 0.071041
RPS17 ribosomal protein S17 0.0579154
JUN jun proto-oncogene 0.0556058
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0548537
AKAP9 A kinase (PRKA) anchor protein 9 0.047601
RPL9 ribosomal protein L9 0.0468019
KLF6 Kruppel-like factor 6 0.0433691
SRRM2 serine/arginine repetitive matrix 2 0.0426753
RACK1 receptor for activated C kinase 1 0.0423043
IGF2 insulin-like growth factor 2 0.0420784
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0415885
MT2A metallothionein 2A 0.0387259
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0386303
PNN pinin, desmosome associated protein 0.0379952
RPL12 ribosomal protein L12 0.0374935
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0374895
GOLGA4 golgin A4 0.0366321
BCLAF1 BCL2-associated transcription factor 1 0.0366037
RPS6 ribosomal protein S6 0.0365422
EIF1 eukaryotic translation initiation factor 1 0.0358885
FTL ferritin, light polypeptide 0.0353898
ATF4 activating transcription factor 4 0.0351846
RPL18 ribosomal protein L18 0.0349312
CCDC88A coiled-coil domain containing 88A 0.0348324
SRSF11 serine/arginine-rich splicing factor 11 0.0345909
DSCAM Down syndrome cell adhesion molecule 0.0344892
RPL35 ribosomal protein L35 0.0332164
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0332041
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.031857
RCC1 regulator of chromosome condensation 1 0.0301399
AKAP12 A kinase (PRKA) anchor protein 12 0.0297074
ZFP36L1 ZFP36 ring finger protein-like 1 0.0293805
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0292436
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0289574
TMEM87A transmembrane protein 87A 0.0289104
PCNX4 pecanex 4 0.0283594
B2M beta-2-microglobulin 0.0282673
ZBTB20 zinc finger and BTB domain containing 20 0.0279885
RPS2 ribosomal protein S2 0.0279849
RHOB ras homolog family member B 0.0279173
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.027834
RPL37 ribosomal protein L37 0.0277384
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0276171
RPS4X ribosomal protein S4, X-linked 0.0274909
CLIP1 CAP-GLY domain containing linker protein 1 0.027051
CEP350 centrosomal protein 350kDa 0.0270401
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 0.0269317
PRRC2C proline-rich coiled-coil 2C 0.0266255
ISG15 ISG15 ubiquitin-like modifier 0.0262621
PRDX2 peroxiredoxin 2 0.0258402
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0258303
BRWD1 bromodomain and WD repeat domain containing 1 0.02557
ASPH aspartate beta-hydroxylase 0.0251851
ENO1 enolase 1, (alpha) 0.0244428
SON SON DNA binding protein 0.0243955
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0242764
BRD2 bromodomain containing 2 0.0238106
RPL31 ribosomal protein L31 0.0236806
WSB1 WD repeat and SOCS box containing 1 0.0236444
SNX3 sorting nexin 3 0.0236283
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0233108
ANKRD12 ankyrin repeat domain 12 0.0229569
FN1 fibronectin 1 0.0229085
SETD5 SET domain containing 5 0.0228094
SFPQ splicing factor proline/glutamine-rich 0.022383
ZNF608 zinc finger protein 608 0.0223077
LDHA lactate dehydrogenase A 0.0222595
ZNF146 zinc finger protein 146 0.0222031
NDRG1 N-myc downstream regulated 1 0.0220026
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0218686
DCAF7 DDB1 and CUL4 associated factor 7 0.0217523
SEM1 SEM1 26S proteasome subunit 0.0217095
RABGAP1L RAB GTPase activating protein 1-like 0.0216455
TPT1 tumor protein, translationally-controlled 1 0.0216099
TMSB10 thymosin beta 10 0.0215869
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.0214796
RPS27 ribosomal protein S27 0.0212795
SEC62 SEC62 homolog (S. cerevisiae) 0.0212415
USP8 ubiquitin specific peptidase 8 0.0211566
JMJD1C jumonji domain containing 1C 0.0209378
PDE4D phosphodiesterase 4D, cAMP-specific 0.020926
KMT5B lysine methyltransferase 5B 0.0209251
PARD3B par-3 family cell polarity regulator beta 0.0209033
RB1CC1 RB1-inducible coiled-coil 1 0.0205516
ATP5F1E ATP synthase F1 subunit epsilon 0.0203941
SET SET nuclear proto-oncogene 0.0202845
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0201947
SCAPER S-phase cyclin A-associated protein in the ER 0.0198434
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.019699
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0195665
MIER1 mesoderm induction early response 1, transcriptional regulator 0.019557
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0194105
EGFR epidermal growth factor receptor 0.0191348
USP22 ubiquitin specific peptidase 22 0.0189201
BRD4 bromodomain containing 4 0.0188891

decreased expression

Symbol Name Standardized Value
TENM3 teneurin transmembrane protein 3 -0.189862
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.111455
ACTG1 actin gamma 1 -0.109105
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0925903
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0846712
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0822028
RAD51B RAD51 paralog B -0.0816682
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.076699
SLIT2 slit homolog 2 (Drosophila) -0.0735206
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0723589
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0675173
KDM3A lysine (K)-specific demethylase 3A -0.0649817
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.057473
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0568654
NCOR1 nuclear receptor corepressor 1 -0.0567979
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0563725
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0562617
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0558763
SMYD3 SET and MYND domain containing 3 -0.054095
TTC28 tetratricopeptide repeat domain 28 -0.0526293
TPD52 tumor protein D52 -0.0522616
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0516865
VCL vinculin -0.050763
OGA O-GlcNAcase -0.0503275
CELF2 CUGBP, Elav-like family member 2 -0.0462204
TUBB tubulin, beta class I -0.0457444
ENAH enabled homolog (Drosophila) -0.0455835
RPL34 ribosomal protein L34 -0.0452909
MKI67 marker of proliferation Ki-67 -0.045214
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0442674
WDR45B WD repeat domain 45B -0.0437537
FUS FUS RNA binding protein -0.0425414
MYL12B myosin, light chain 12B, regulatory -0.0424601
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0418485
MCTP1 multiple C2 domains, transmembrane 1 -0.0418263
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0417294
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0412333
VDAC1 voltage-dependent anion channel 1 -0.0411681
FOXO3 forkhead box O3 -0.0404086
PTMA prothymosin, alpha -0.0395763
ZFAND3 zinc finger, AN1-type domain 3 -0.0394161
ZNF544 zinc finger protein 544 -0.0393133
H1-0 H1.0 linker histone -0.0390169
PARD3 par-3 family cell polarity regulator -0.0382219
HMGB1 high mobility group box 1 -0.0377789
RPL8 ribosomal protein L8 -0.0376217
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.037178
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0368947
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0363321
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0354128
HDLBP high density lipoprotein binding protein -0.0350096
ZNF33A zinc finger protein 33A -0.0349227
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0346496
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.034359
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0342316
NPAS3 neuronal PAS domain protein 3 -0.0340768
RERE arginine-glutamic acid dipeptide (RE) repeats -0.033834
TMEM123 transmembrane protein 123 -0.033509
RPLP1 ribosomal protein, large, P1 -0.0331972
MDN1 MDN1, midasin homolog (yeast) -0.0329507
APP amyloid beta (A4) precursor protein -0.0328956
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0314507
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0314094
CBFB core-binding factor, beta subunit -0.0310965
SHROOM3 shroom family member 3 -0.0310681
MXI1 MAX interactor 1, dimerization protein -0.0306926
RIGI RNA sensor RIG-I -0.0304567
ZNF638 zinc finger protein 638 -0.0303595
RNMT RNA (guanine-7-) methyltransferase -0.0302645
FMNL2 formin-like 2 -0.0302002
NF1 neurofibromin 1 -0.0301792
RPS24 ribosomal protein S24 -0.0301712
TBC1D32 TBC1 domain family, member 32 -0.0297966
SREBF2 sterol regulatory element binding transcription factor 2 -0.029564
JAM3 junctional adhesion molecule 3 -0.0295598
GSK3B glycogen synthase kinase 3 beta -0.0292788
MIPOL1 mirror-image polydactyly 1 -0.029195
BLTP2 bridge-like lipid transfer protein family member 2 -0.0291463
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0290973
ACACA acetyl-CoA carboxylase alpha -0.0289761
ZFP64 ZFP64 zinc finger protein -0.0286972
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0284292
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0283926
STAU1 staufen double-stranded RNA binding protein 1 -0.0282437
CD2AP CD2-associated protein -0.0281437
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.0277927
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0276763
DEK DEK proto-oncogene -0.0276219
SNX14 sorting nexin 14 -0.0276166
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0274667
TRIO trio Rho guanine nucleotide exchange factor -0.0274468
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.0273099
PFN1 profilin 1 -0.0272221
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0271291
TMEM135 transmembrane protein 135 -0.0269818
NT5C2 5'-nucleotidase, cytosolic II -0.0269767
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0269758
CHD4 chromodomain helicase DNA binding protein 4 -0.0269088
RYBP RING1 and YY1 binding protein -0.0267762
SOX4 SRY (sex determining region Y)-box 4 -0.0265254