18β-Glycyrrhetinic acid_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.208695
VIM vimentin 0.205063
NAMPT nicotinamide phosphoribosyltransferase 0.112518
AKAP12 A kinase (PRKA) anchor protein 12 0.107768
IFI16 interferon, gamma-inducible protein 16 0.106661
ASPH aspartate beta-hydroxylase 0.0915458
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0908908
ENO1 enolase 1, (alpha) 0.0879623
IGFBP5 insulin-like growth factor binding protein 5 0.0849755
NDRG1 N-myc downstream regulated 1 0.081169
TMSB10 thymosin beta 10 0.0793237
TAGLN2 transgelin 2 0.0739721
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0722929
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0708058
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0707294
IGFBP3 insulin-like growth factor binding protein 3 0.0695511
B2M beta-2-microglobulin 0.0671327
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0668566
CENPF centromere protein F, 350/400kDa 0.0632369
RPS12 ribosomal protein S12 0.0534126
TIMP3 TIMP metallopeptidase inhibitor 3 0.0524681
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0515119
LDHA lactate dehydrogenase A 0.049544
ANKRD12 ankyrin repeat domain 12 0.0491775
IFI6 interferon, alpha-inducible protein 6 0.0485059
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0482456
WSB1 WD repeat and SOCS box containing 1 0.0479972
TPT1 tumor protein, translationally-controlled 1 0.0477424
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0475738
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0450135
IFITM3 interferon induced transmembrane protein 3 0.0449905
PRELID2 PRELI domain containing 2 0.0435738
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0431924
RPL37A ribosomal protein L37a 0.0424214
FLNB filamin B, beta 0.0405222
TNNC1 troponin C type 1 (slow) 0.0405182
EXOC4 exocyst complex component 4 0.0405059
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0388762
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0386444
FMNL2 formin-like 2 0.0385098
ANXA2 annexin A2 0.0382867
NAP1L1 nucleosome assembly protein 1-like 1 0.037834
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0376692
RPLP1 ribosomal protein, large, P1 0.0367716
LGALS1 lectin, galactoside-binding, soluble, 1 0.0363413
GPC6 glypican 6 0.036147
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0360368
VCL vinculin 0.0358606
PCDH7 protocadherin 7 0.0357125
HLA-B major histocompatibility complex, class I, B 0.0351824
TPR translocated promoter region, nuclear basket protein 0.0348799
NAV2 neuron navigator 2 0.0348278
RPS19 ribosomal protein S19 0.0340413
ZSWIM6 zinc finger, SWIM-type containing 6 0.0337526
CAV1 caveolin 1, caveolae protein, 22kDa 0.0335359
ENO2 enolase 2 (gamma, neuronal) 0.0333913
IFITM1 interferon induced transmembrane protein 1 0.033385
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0322777
ADM adrenomedullin 0.0314062
OXR1 oxidation resistance 1 0.0312753
IFRD1 interferon-related developmental regulator 1 0.0310884
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0310631
OSMR oncostatin M receptor 0.0309018
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0308143
RPS3 ribosomal protein S3 0.0307102
NIPBL Nipped-B homolog (Drosophila) 0.030598
KTN1 kinectin 1 (kinesin receptor) 0.0303692
RPL23 ribosomal protein L23 0.0299199
RPL11 ribosomal protein L11 0.0298992
BACE2 beta-site APP-cleaving enzyme 2 0.0294814
RACK1 receptor for activated C kinase 1 0.0292428
TMEM178B transmembrane protein 178B 0.0291885
MT1X metallothionein 1X 0.0290905
SDC2 syndecan 2 0.0290728
DDIT4 DNA-damage-inducible transcript 4 0.0287602
RPL12 ribosomal protein L12 0.0286708
ACTN1 actinin, alpha 1 0.0286707
RPL31 ribosomal protein L31 0.0285396
RPL26 ribosomal protein L26 0.0283687
UQCRB ubiquinol-cytochrome c reductase binding protein 0.027841
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0276797
FTL ferritin, light polypeptide 0.0276493
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0275961
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0274798
RPL18 ribosomal protein L18 0.0273095
LOC112694756 uncharaterized LOC112694756 0.0272514
RPL36 ribosomal protein L36 0.0269548
SDCCAG8 serologically defined colon cancer antigen 8 0.0268232
RRBP1 ribosome binding protein 1 0.0266376
CAVIN1 caveolae associated protein 1 0.0266255
HP1BP3 heterochromatin protein 1, binding protein 3 0.0263541
AFDN afadin, adherens junction formation factor 0.0262849
PGK1 phosphoglycerate kinase 1 0.0258371
TM4SF1 transmembrane 4 L six family member 1 0.025726
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0256388
RPS6 ribosomal protein S6 0.0253125
RPL9 ribosomal protein L9 0.0252296
LOC102724023 ES1 protein homolog, mitochondrial 0.0252
YBX3 Y box binding protein 3 0.0250114
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0249857

decreased expression

Symbol Name Standardized Value
VGF VGF nerve growth factor inducible -0.177563
DCT dopachrome tautomerase -0.112661
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0942813
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0812428
NAV3 neuron navigator 3 -0.0664945
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0616475
PDIA3 protein disulfide isomerase family A, member 3 -0.0532596
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0496132
GDF15 growth differentiation factor 15 -0.0469584
NBAS neuroblastoma amplified sequence -0.0468139
KMT2C lysine (K)-specific methyltransferase 2C -0.0465367
TRIM2 tripartite motif containing 2 -0.0458525
HMCN1 hemicentin 1 -0.0449314
MYO10 myosin X -0.04225
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0398489
CALU calumenin -0.0387463
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0383033
MACROD2 MACRO domain containing 2 -0.0380475
UBE2H ubiquitin-conjugating enzyme E2H -0.036484
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0359033
FRMD4A FERM domain containing 4A -0.0358982
PDE10A phosphodiesterase 10A -0.0319883
SETD5 SET domain containing 5 -0.0310011
NLGN1 neuroligin 1 -0.0307754
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0303767
AHCYL2 adenosylhomocysteinase-like 2 -0.0299537
INSIG1 insulin induced gene 1 -0.0288831
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0287971
SCFD2 sec1 family domain containing 2 -0.02878
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0286244
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0283683
TULP4 tubby like protein 4 -0.028109
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0275387
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0273229
LAMB1 laminin, beta 1 -0.0270512
ANKRD28 ankyrin repeat domain 28 -0.0263306
RFX7 regulatory factor X, 7 -0.0261683
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0255008
SOX5 SRY (sex determining region Y)-box 5 -0.0254355
POM121 POM121 transmembrane nucleoporin -0.0253269
C1ORF21 chromosome 1 open reading frame 21 -0.0253209
SRPK2 SRSF protein kinase 2 -0.0248994
GNAS GNAS complex locus -0.0243555
HSPG2 heparan sulfate proteoglycan 2 -0.024284
DST dystonin -0.0239854
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0239769
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0231972
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0227314
RNF24 ring finger protein 24 -0.0225346
LSAMP limbic system-associated membrane protein -0.0223911
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0222987
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.022268
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0221077
SREBF2 sterol regulatory element binding transcription factor 2 -0.022038
HILPDA hypoxia inducible lipid droplet-associated -0.0218011
CDK14 cyclin-dependent kinase 14 -0.0215223
BSG basigin (Ok blood group) -0.0215019
TMEM123 transmembrane protein 123 -0.021087
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -0.0208997
RBM33 RNA binding motif protein 33 -0.0206598
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0206261
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0204406
GOLGA4 golgin A4 -0.0201314
CASD1 CAS1 domain containing 1 -0.0200929
MITF microphthalmia-associated transcription factor -0.0199174
CYB5R3 cytochrome b5 reductase 3 -0.0199062
CD109 CD109 molecule -0.0198453
CALD1 caldesmon 1 -0.019786
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0193877
MDM4 MDM4, p53 regulator -0.0192089
MICU2 mitochondrial calcium uptake 2 -0.0189654
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0189515
FBXL7 F-box and leucine-rich repeat protein 7 -0.018795
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0187373
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0186537
S100A6 S100 calcium binding protein A6 -0.0186441
MIDEAS mitotic deacetylase associated SANT domain protein -0.0186038
COL19A1 collagen, type XIX, alpha 1 -0.0185229
WDR45B WD repeat domain 45B -0.0184706
NRCAM neuronal cell adhesion molecule -0.0183388
SESN3 sestrin 3 -0.0183289
FRMD6 FERM domain containing 6 -0.0182165
C10ORF90 chromosome 10 open reading frame 90 -0.0178857
RNF144A ring finger protein 144A -0.0178507
UBE3C ubiquitin protein ligase E3C -0.0177249
CTTNBP2 cortactin binding protein 2 -0.0176978
SCARB1 scavenger receptor class B, member 1 -0.017559
EPHA3 EPH receptor A3 -0.0175308
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0174613
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -0.0172223
HSPB1 heat shock 27kDa protein 1 -0.0170752
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0170582
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0168609
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0168247
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0167896
PTCHD4 patched domain containing 4 -0.0167731
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.016739
STXBP1 syntaxin binding protein 1 -0.0167358
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0166937
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0166179