18β-Glycyrrhetinic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.171535
NDRG1 N-myc downstream regulated 1 0.130633
LAMA4 laminin, alpha 4 0.121228
RPL23 ribosomal protein L23 0.0988034
LAMB3 laminin, beta 3 0.0886335
ENO1 enolase 1, (alpha) 0.0851409
AKAP12 A kinase (PRKA) anchor protein 12 0.0813758
B2M beta-2-microglobulin 0.0699803
EZR ezrin 0.0690727
C15ORF48 chromosome 15 open reading frame 48 0.0595736
HLA-A major histocompatibility complex, class I, A 0.0559321
LDHA lactate dehydrogenase A 0.0555309
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0537674
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0526002
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0515669
AHNAK2 AHNAK nucleoprotein 2 0.0495009
LAMC2 laminin, gamma 2 0.0457504
EIF1 eukaryotic translation initiation factor 1 0.0451924
ERRFI1 ERBB receptor feedback inhibitor 1 0.0449759
ANXA1 annexin A1 0.0439432
RPS3 ribosomal protein S3 0.0437723
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0429671
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0429413
RPL11 ribosomal protein L11 0.0425298
FAM110C family with sequence similarity 110, member C 0.0406881
BZW1 basic leucine zipper and W2 domains 1 0.0400129
ARHGAP5 Rho GTPase activating protein 5 0.0391995
SMAD3 SMAD family member 3 0.038474
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.038245
KRT19 keratin 19, type I 0.0381436
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0376675
BLZF1 basic leucine zipper nuclear factor 1 0.0373309
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0369207
GRB10 growth factor receptor-bound protein 10 0.0362373
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0361116
KLF6 Kruppel-like factor 6 0.036001
ANXA2 annexin A2 0.0359024
ZSWIM6 zinc finger, SWIM-type containing 6 0.0357906
RPL37A ribosomal protein L37a 0.0352906
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347871
APLP2 amyloid beta (A4) precursor-like protein 2 0.0334371
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0331231
FAM13A family with sequence similarity 13, member A 0.0329152
SFTPA2 surfactant protein A2 0.0322537
RPS19 ribosomal protein S19 0.0306864
SGMS2 sphingomyelin synthase 2 0.030146
BACE2 beta-site APP-cleaving enzyme 2 0.0297959
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0293276
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0290978
RACK1 receptor for activated C kinase 1 0.029082
GOLGB1 golgin B1 0.0282006
RPS17 ribosomal protein S17 0.028193
VEGFA vascular endothelial growth factor A 0.0279314
MXI1 MAX interactor 1, dimerization protein 0.0277689
MAP1B microtubule-associated protein 1B 0.0274946
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0274403
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0272551
MTSS1 metastasis suppressor 1 0.0272241
JAK1 Janus kinase 1 0.0272225
KDM3A lysine (K)-specific demethylase 3A 0.0270358
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0270267
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0266985
RPL12 ribosomal protein L12 0.0266589
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.026399
LCN2 lipocalin 2 0.0261776
ZMIZ1 zinc finger, MIZ-type containing 1 0.026174
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.026156
FTL ferritin, light polypeptide 0.026126
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0257711
NAP1L1 nucleosome assembly protein 1-like 1 0.0256163
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0254802
RPL37 ribosomal protein L37 0.0251884
CSNK1A1 casein kinase 1, alpha 1 0.025104
ASPH aspartate beta-hydroxylase 0.0250858
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0250203
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0249629
FLNB filamin B, beta 0.0249156
IRS2 insulin receptor substrate 2 0.0246634
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0240682
SERINC1 serine incorporator 1 0.0240141
SACK1A scaffolding CK1 anchoring protein A 0.0237592
ESYT2 extended synaptotagmin-like protein 2 0.0230907
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0226404
SH3KBP1 SH3-domain kinase binding protein 1 0.0224838
SAMD9 sterile alpha motif domain containing 9 0.0223855
INTS6 integrator complex subunit 6 0.0222668
TAGLN2 transgelin 2 0.0221731
SEPTIN2 septin 2 0.0212076
ALCAM activated leukocyte cell adhesion molecule 0.0209764
TES testin LIM domain protein 0.0208391
RPS12 ribosomal protein S12 0.0204181
CSTB cystatin B (stefin B) 0.0203833
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0202679
RPL31 ribosomal protein L31 0.020219
RPS24 ribosomal protein S24 0.0201111
SRSF5 serine/arginine-rich splicing factor 5 0.0199234
TFPI2 tissue factor pathway inhibitor 2 0.0198881
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0198247
VIM vimentin 0.0197693
ANGPTL4 angiopoietin-like 4 0.0197564

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.11434
PARD3 par-3 family cell polarity regulator -0.0995639
HLA-B major histocompatibility complex, class I, B -0.0884546
MUC4 mucin 4, cell surface associated -0.081256
ACTG1 actin gamma 1 -0.0764502
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0759035
FNDC3B fibronectin type III domain containing 3B -0.0754246
ARHGAP26 Rho GTPase activating protein 26 -0.0705712
PTMA prothymosin, alpha -0.0678382
PATJ PATJ crumbs cell polarity complex component -0.0647409
MMP7 matrix metallopeptidase 7 -0.0639785
RNF213 ring finger protein 213 -0.0615905
RTN4 reticulon 4 -0.060177
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0599857
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0582304
NPEPPS aminopeptidase puromycin sensitive -0.0561276
NT5C2 5'-nucleotidase, cytosolic II -0.0545826
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0530536
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0506768
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0504391
CCNL1 cyclin L1 -0.0497244
UBE2H ubiquitin-conjugating enzyme E2H -0.0495123
PCDH7 protocadherin 7 -0.0492643
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0483582
TPM1 tropomyosin 1 (alpha) -0.0479004
MX1 MX dynamin-like GTPase 1 -0.0476991
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0474313
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0467011
TAPBP TAP binding protein (tapasin) -0.0460722
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0454544
AKAP13 A kinase (PRKA) anchor protein 13 -0.0453952
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0446316
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0436036
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0435386
S100A6 S100 calcium binding protein A6 -0.0435339
MAML2 mastermind-like 2 (Drosophila) -0.0430559
TMEM165 transmembrane protein 165 -0.0426217
SPAG9 sperm associated antigen 9 -0.0426032
OSMR oncostatin M receptor -0.0423819
MX2 MX dynamin-like GTPase 2 -0.0423759
STRN3 striatin, calmodulin binding protein 3 -0.040687
MACC1 metastasis associated in colon cancer 1 -0.0405611
PLAT plasminogen activator, tissue -0.0403481
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0397069
DST dystonin -0.0396177
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0395976
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0391317
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0386471
WWC1 WW and C2 domain containing 1 -0.0381246
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0378249
ACTN4 actinin, alpha 4 -0.0375713
INSIG1 insulin induced gene 1 -0.037428
RAB6A RAB6A, member RAS oncogene family -0.037235
BCL2L1 BCL2-like 1 -0.0365627
JMJD1C jumonji domain containing 1C -0.0363958
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0363809
TMOD3 tropomodulin 3 (ubiquitous) -0.0358285
CP ceruloplasmin (ferroxidase) -0.0353684
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0352488
CDK6 cyclin-dependent kinase 6 -0.0348012
MCU mitochondrial calcium uniporter -0.034785
NPC1 Niemann-Pick disease, type C1 -0.0341222
ADAM9 ADAM metallopeptidase domain 9 -0.0341086
MACF1 microtubule-actin crosslinking factor 1 -0.0339471
GSK3B glycogen synthase kinase 3 beta -0.0337028
PDIA3 protein disulfide isomerase family A, member 3 -0.0337024
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0333347
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0329733
NUP58 nucleoporin 58 -0.0328665
WAC WW domain containing adaptor with coiled-coil -0.03271
CFLAR CASP8 and FADD-like apoptosis regulator -0.0324559
TC2N tandem C2 domains, nuclear -0.0324505
CD2AP CD2-associated protein -0.0322096
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0319886
JUP junction plakoglobin -0.0319856
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0319516
IFI27 interferon, alpha-inducible protein 27 -0.0318265
NCKAP5 NCK-associated protein 5 -0.0313135
PKM pyruvate kinase, muscle -0.031264
NRP1 neuropilin 1 -0.0308189
TSC22D2 TSC22 domain family, member 2 -0.0303322
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0301414
WARS1 tryptophanyl-tRNA synthetase 1 -0.0300611
ZFAND3 zinc finger, AN1-type domain 3 -0.0298325
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0296623
UBE2K ubiquitin-conjugating enzyme E2K -0.0291772
PTK2 protein tyrosine kinase 2 -0.0288538
F3 coagulation factor III (thromboplastin, tissue factor) -0.0288141
RBM47 RNA binding motif protein 47 -0.028763
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0286009
ANXA11 annexin A11 -0.0283393
PMP22 peripheral myelin protein 22 -0.0282076
PDLIM5 PDZ and LIM domain 5 -0.0280841
DPYD dihydropyrimidine dehydrogenase -0.0280018
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0278719
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0268123
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0265925
SREBF2 sterol regulatory element binding transcription factor 2 -0.0264227
C6ORF132 chromosome 6 open reading frame 132 -0.0263981
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0263104