18β-Glycyrrhetinic acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.301002
B2M beta-2-microglobulin 0.147667
AKAP12 A kinase (PRKA) anchor protein 12 0.140211
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104344
ASPH aspartate beta-hydroxylase 0.0974128
TIMP1 TIMP metallopeptidase inhibitor 1 0.0846685
NDRG1 N-myc downstream regulated 1 0.0842048
COL6A3 collagen, type VI, alpha 3 0.082107
STC1 stanniocalcin 1 0.0783082
FTL ferritin, light polypeptide 0.0776506
TPT1 tumor protein, translationally-controlled 1 0.076236
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0760558
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0746297
TGFBI transforming growth factor, beta-induced, 68kDa 0.0734661
RPL37A ribosomal protein L37a 0.072126
RPS3 ribosomal protein S3 0.0685452
VIM vimentin 0.0662028
LDHA lactate dehydrogenase A 0.0647816
RACK1 receptor for activated C kinase 1 0.0634917
LOX lysyl oxidase 0.0626605
HLA-A major histocompatibility complex, class I, A 0.0607607
RPS19 ribosomal protein S19 0.0575973
NAMPT nicotinamide phosphoribosyltransferase 0.0575838
HLA-B major histocompatibility complex, class I, B 0.0571817
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0566892
CD44 CD44 molecule (Indian blood group) 0.0531946
ENO1 enolase 1, (alpha) 0.0519351
EIF1 eukaryotic translation initiation factor 1 0.049662
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0495905
SMAD3 SMAD family member 3 0.0481402
RPL28 ribosomal protein L28 0.046682
CD59 CD59 molecule, complement regulatory protein 0.0456064
RPS8 ribosomal protein S8 0.043006
RPL12 ribosomal protein L12 0.0426332
PLAUR plasminogen activator, urokinase receptor 0.0417577
RPS27A ribosomal protein S27a 0.040752
RPS20 ribosomal protein S20 0.0406594
RPL37 ribosomal protein L37 0.0404169
WWTR1 WW domain containing transcription regulator 1 0.0393289
NFE2L1 nuclear factor, erythroid 2-like 1 0.0384238
MCFD2 multiple coagulation factor deficiency 2 0.0382758
RPL19 ribosomal protein L19 0.0381437
RPL35A ribosomal protein L35a 0.0360451
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0360217
RPL36 ribosomal protein L36 0.0357395
RPL23 ribosomal protein L23 0.0356566
RPS12 ribosomal protein S12 0.0356335
RPL18 ribosomal protein L18 0.0352745
RPS17 ribosomal protein S17 0.035162
OSMR oncostatin M receptor 0.0347558
MT1X metallothionein 1X 0.0342034
LOC112694756 uncharaterized LOC112694756 0.0336331
RIGI RNA sensor RIG-I 0.0335164
ZNF841 zinc finger protein 841 0.0332309
TIMP3 TIMP metallopeptidase inhibitor 3 0.0330598
FAM107B family with sequence similarity 107, member B 0.0329245
SEC61G Sec61 gamma subunit 0.0328498
LGALS1 lectin, galactoside-binding, soluble, 1 0.0318566
NACA nascent polypeptide-associated complex alpha subunit 0.0313753
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0310674
PGK1 phosphoglycerate kinase 1 0.030479
EGR1 early growth response 1 0.0304753
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0301134
RPL26 ribosomal protein L26 0.0300866
BACE2 beta-site APP-cleaving enzyme 2 0.0298037
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0297674
RPS6 ribosomal protein S6 0.0295637
RPL31 ribosomal protein L31 0.0292296
RPL9 ribosomal protein L9 0.028702
ANXA2 annexin A2 0.0282453
LOXL2 lysyl oxidase-like 2 0.0282248
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0282075
SEC31A SEC31 homolog A (S. cerevisiae) 0.0281521
TXNIP thioredoxin interacting protein 0.0275204
RPL11 ribosomal protein L11 0.0273884
ATF4 activating transcription factor 4 0.0269519
RPLP2 ribosomal protein, large, P2 0.0264677
COL5A1 collagen, type V, alpha 1 0.0263679
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0263261
LMAN1 lectin, mannose-binding, 1 0.02625
ZNF292 zinc finger protein 292 0.0260814
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0258439
MACF1 microtubule-actin crosslinking factor 1 0.0258164
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0246855
RPS27 ribosomal protein S27 0.0246199
CSDE1 cold shock domain containing E1, RNA-binding 0.024512
NFE2L2 nuclear factor, erythroid 2-like 2 0.0242577
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0239531
WSB1 WD repeat and SOCS box containing 1 0.023937
TPI1 triosephosphate isomerase 1 0.0239308
CLIC1 chloride intracellular channel 1 0.0238813
ZBTB20 zinc finger and BTB domain containing 20 0.0237865
RPL35 ribosomal protein L35 0.0237242
INHBA inhibin, beta A 0.0233931
RPS13 ribosomal protein S13 0.0231859
CAVIN1 caveolae associated protein 1 0.0231412
HIPK2 homeodomain interacting protein kinase 2 0.0231013
RPL38 ribosomal protein L38 0.02299
PTPRM protein tyrosine phosphatase, receptor type, M 0.022532
RPS24 ribosomal protein S24 0.022441

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.107813
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.083764
GRB10 growth factor receptor-bound protein 10 -0.0705493
TPM4 tropomyosin 4 -0.0633391
FN1 fibronectin 1 -0.0549935
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0462727
GLS2 glutaminase 2 (liver, mitochondrial) -0.0454098
POTEF POTE ankyrin domain family, member F -0.0445976
PTMA prothymosin, alpha -0.0444574
DST dystonin -0.0442515
HILPDA hypoxia inducible lipid droplet-associated -0.0438123
RAB7A RAB7A, member RAS oncogene family -0.0436271
CENPF centromere protein F, 350/400kDa -0.0396268
PDIA3 protein disulfide isomerase family A, member 3 -0.0390978
SDK1 sidekick cell adhesion molecule 1 -0.0388858
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0364888
NLGN1 neuroligin 1 -0.0360495
PTPRG protein tyrosine phosphatase, receptor type, G -0.0353141
CENPE centromere protein E, 312kDa -0.0351026
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0350786
NAV2 neuron navigator 2 -0.0349957
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0348486
CD99 CD99 molecule -0.03478
SPAG9 sperm associated antigen 9 -0.033534
TPX2 TPX2, microtubule-associated -0.0328667
ACTG1 actin gamma 1 -0.0314998
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0313377
NAV1 neuron navigator 1 -0.0312528
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0308136
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0304154
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0303104
COMMD10 COMM domain containing 10 -0.0301345
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0300653
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0300309
COG5 component of oligomeric golgi complex 5 -0.0298749
TNS3 tensin 3 -0.0296142
TRA2A transformer 2 alpha homolog (Drosophila) -0.0294214
ITGAV integrin, alpha V -0.0293414
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0289481
EGFR epidermal growth factor receptor -0.0288753
PKM pyruvate kinase, muscle -0.0286832
PTGES2 prostaglandin E synthase 2 -0.0284717
TUBA1B tubulin, alpha 1b -0.0282166
BIRC6 baculoviral IAP repeat containing 6 -0.0279669
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0275292
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0272906
ACBD3 acyl-CoA binding domain containing 3 -0.0271818
ANLN anillin, actin binding protein -0.0266731
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0261668
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0259717
PDE4D phosphodiesterase 4D, cAMP-specific -0.0259258
LCORL ligand dependent nuclear receptor corepressor-like -0.0253341
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0250666
CUX1 cut-like homeobox 1 -0.0250287
DIAPH3 diaphanous-related formin 3 -0.0247105
PIAS2 protein inhibitor of activated STAT, 2 -0.0245057
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0243245
MMP12 matrix metallopeptidase 12 -0.0240995
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0237316
COL5A2 collagen, type V, alpha 2 -0.0235828
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.023549
XYLT1 xylosyltransferase I -0.0235242
SBF2 SET binding factor 2 -0.0234651
MAP1B microtubule-associated protein 1B -0.023232
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0230581
BRD2 bromodomain containing 2 -0.0230513
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0230093
MAP4 microtubule-associated protein 4 -0.0228857
COPA coatomer protein complex, subunit alpha -0.0226003
NALF1 NALCN channel auxiliary factor 1 -0.0225777
PCDHB16 protocadherin beta 16 -0.022558
KCMF1 potassium channel modulatory factor 1 -0.0224857
CFDP1 craniofacial development protein 1 -0.022372
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0222906
UBAP2 ubiquitin associated protein 2 -0.0221267
ADAM9 ADAM metallopeptidase domain 9 -0.0221175
LCOR ligand dependent nuclear receptor corepressor -0.0221115
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0220252
RAB1A RAB1A, member RAS oncogene family -0.0219577
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0218288
KPNB1 karyopherin (importin) beta 1 -0.0216092
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0214102
SETX senataxin -0.021346
TCERG1 transcription elongation regulator 1 -0.0212489
UBE2K ubiquitin-conjugating enzyme E2K -0.0212488
CANX calnexin -0.0211335
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0211058
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0209869
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0208922
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0208381
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0208354
ZNF451 zinc finger protein 451 -0.0207108
ZFAND3 zinc finger, AN1-type domain 3 -0.0205723
DCAF7 DDB1 and CUL4 associated factor 7 -0.0204051
SENP6 SUMO1/sentrin specific peptidase 6 -0.0203525
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0203428
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0201479
SCLT1 sodium channel and clathrin linker 1 -0.020146
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -0.0201442
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0200207