| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 18β-Glycyrrhetinic acid perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 18β-Glycyrrhetinic acid_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.22115 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.187197 |
| VEGFA | vascular endothelial growth factor A | 0.183415 |
| MT2A | metallothionein 2A | 0.175214 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.133277 |
| TMSB10 | thymosin beta 10 | 0.0731108 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0667778 |
| HLA-A | major histocompatibility complex, class I, A | 0.0561215 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.054472 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0528086 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0527855 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0515007 |
| LDHA | lactate dehydrogenase A | 0.0514096 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0511921 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.050411 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0499586 |
| B2M | beta-2-microglobulin | 0.0480963 |
| MAP1B | microtubule-associated protein 1B | 0.0462091 |
| RPL23 | ribosomal protein L23 | 0.0429961 |
| CD44 | CD44 molecule (Indian blood group) | 0.0425956 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0407137 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0392568 |
| HMGA2 | high mobility group AT-hook 2 | 0.0384222 |
| RPS19 | ribosomal protein S19 | 0.0372403 |
| MSN | moesin | 0.0362945 |
| TAGLN2 | transgelin 2 | 0.0348737 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0340987 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0332757 |
| ENO1 | enolase 1, (alpha) | 0.0332517 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0324755 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.031873 |
| SON | SON DNA binding protein | 0.0315095 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0307658 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0307069 |
| HDAC9 | histone deacetylase 9 | 0.0306333 |
| POSTN | periostin, osteoblast specific factor | 0.0306045 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0303427 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0300962 |
| SQLE | squalene epoxidase | 0.030088 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0293238 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0292108 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0288607 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.028802 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.0281875 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0281861 |
| PKM | pyruvate kinase, muscle | 0.0280669 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0276327 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0275169 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0268689 |
| BBX | bobby sox homolog (Drosophila) | 0.0268031 |
| EGR1 | early growth response 1 | 0.0267347 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0266865 |
| PCBP2 | poly(rC) binding protein 2 | 0.0265648 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0265324 |
| DSTN | destrin (actin depolymerizing factor) | 0.0264001 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0259747 |
| HMGA1 | high mobility group AT-hook 1 | 0.0257654 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0249076 |
| RPS6 | ribosomal protein S6 | 0.0248981 |
| RPL18 | ribosomal protein L18 | 0.0246714 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.024002 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0236649 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0233796 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0232802 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0232744 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0232074 |
| ATP13A3 | ATPase type 13A3 | 0.0231387 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0230684 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0229865 |
| PFN1 | profilin 1 | 0.0229256 |
| RPL12 | ribosomal protein L12 | 0.0229002 |
| TPI1 | triosephosphate isomerase 1 | 0.0226958 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0224879 |
| RASA2 | RAS p21 protein activator 2 | 0.0221661 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0221132 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0219272 |
| SMAD3 | SMAD family member 3 | 0.0218087 |
| TRAM1 | translocation associated membrane protein 1 | 0.0215702 |
| VMP1 | vacuole membrane protein 1 | 0.0215252 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0214686 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0214174 |
| LOX | lysyl oxidase | 0.021217 |
| SPAG9 | sperm associated antigen 9 | 0.0211843 |
| NAV2 | neuron navigator 2 | 0.0209339 |
| AXL | AXL receptor tyrosine kinase | 0.020632 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0205135 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0204549 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0204541 |
| PGM3 | phosphoglucomutase 3 | 0.0203162 |
| FTL | ferritin, light polypeptide | 0.0200409 |
| RPL7 | ribosomal protein L7 | 0.0200047 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0198523 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0197825 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0196778 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0196491 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0194778 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0194774 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0194154 |
| RBM25 | RNA binding motif protein 25 | 0.0193743 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0191836 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.318972 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.163828 |
| IER3 | immediate early response 3 | -0.159651 |
| COL1A2 | collagen, type I, alpha 2 | -0.139746 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.123645 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.119669 |
| COL5A1 | collagen, type V, alpha 1 | -0.117039 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.115474 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112121 |
| CDH13 | cadherin 13 | -0.106676 |
| TPM4 | tropomyosin 4 | -0.0951888 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0652335 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0552381 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0550502 |
| VIM | vimentin | -0.0509412 |
| CADM1 | cell adhesion molecule 1 | -0.0500937 |
| ACTG1 | actin gamma 1 | -0.0493851 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.048615 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0462912 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0433024 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0429282 |
| CAVIN1 | caveolae associated protein 1 | -0.041311 |
| LOXL2 | lysyl oxidase-like 2 | -0.0411154 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0396155 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0395911 |
| IL6 | interleukin 6 | -0.0395155 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0380987 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0375456 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0366919 |
| CLMP | CXADR-like membrane protein | -0.0363761 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0359704 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0345794 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0345462 |
| MTDH | metadherin | -0.0343589 |
| RUNX1 | runt-related transcription factor 1 | -0.0339858 |
| GNAS | GNAS complex locus | -0.033983 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0333381 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0325175 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323201 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0321862 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0317562 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0316946 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0308453 |
| CCDC91 | coiled-coil domain containing 91 | -0.0303791 |
| CALU | calumenin | -0.0299668 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0287615 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0282218 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0280666 |
| CALD1 | caldesmon 1 | -0.027861 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.027855 |
| RPS8 | ribosomal protein S8 | -0.0271854 |
| FBN1 | fibrillin 1 | -0.0264046 |
| YEATS2 | YEATS domain containing 2 | -0.0262592 |
| ZFHX3 | zinc finger homeobox 3 | -0.0262335 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0260395 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0260393 |
| RPL35A | ribosomal protein L35a | -0.0258321 |
| RLF | rearranged L-myc fusion | -0.0256906 |
| AHNAK | AHNAK nucleoprotein | -0.0252639 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0249951 |
| UBC | ubiquitin C | -0.0249127 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0246835 |
| RPL38 | ribosomal protein L38 | -0.0238346 |
| ADM | adrenomedullin | -0.0237776 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0233776 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0232179 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0230623 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0223097 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0219039 |
| HLA-E | major histocompatibility complex, class I, E | -0.0216326 |
| S100A10 | S100 calcium binding protein A10 | -0.0212047 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0211149 |
| CTSB | cathepsin B | -0.0210289 |
| BNC2 | basonuclin 2 | -0.0209295 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0208794 |
| S100A6 | S100 calcium binding protein A6 | -0.0207935 |
| CUX1 | cut-like homeobox 1 | -0.0207392 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0204709 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0203419 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0202922 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0198795 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0196294 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.019593 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0194338 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0194311 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0194152 |
| MMP3 | matrix metallopeptidase 3 | -0.019358 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0191606 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0191279 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0191113 |
| PDE10A | phosphodiesterase 10A | -0.0189702 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0189029 |
| MTSS1 | metastasis suppressor 1 | -0.0189015 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.018768 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0187001 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0186048 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.018591 |
| SAFB2 | scaffold attachment factor B2 | -0.0185852 |
| STC1 | stanniocalcin 1 | -0.0183441 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0182368 |
