18β-Glycyrrhetinic acid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.411674
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.224613
MT2A metallothionein 2A 0.135548
TIMP1 TIMP metallopeptidase inhibitor 1 0.113682
RPL37A ribosomal protein L37a 0.110152
RPS12 ribosomal protein S12 0.105927
C3 complement component 3 0.105876
RPL23 ribosomal protein L23 0.0930268
IGFBP1 insulin-like growth factor binding protein 1 0.0817491
FTL ferritin, light polypeptide 0.0697401
TF transferrin 0.0655997
RPS19 ribosomal protein S19 0.0655193
RPL11 ribosomal protein L11 0.0630747
RPL31 ribosomal protein L31 0.0604678
RPS6 ribosomal protein S6 0.0571838
RPS8 ribosomal protein S8 0.0543714
RPL9 ribosomal protein L9 0.0538066
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0521521
VEGFA vascular endothelial growth factor A 0.0514159
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477383
AHSG alpha-2-HS-glycoprotein 0.0454258
RPS3 ribosomal protein S3 0.0441772
APOA1 apolipoprotein A-I 0.0441709
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0428485
RPL36 ribosomal protein L36 0.0427426
AFDN afadin, adherens junction formation factor 0.0414958
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0408478
ENO1 enolase 1, (alpha) 0.0397344
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0385416
SVIL supervillin 0.0372681
EEF2 eukaryotic translation elongation factor 2 0.0362405
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0361516
B2M beta-2-microglobulin 0.0356602
RPS17 ribosomal protein S17 0.0354932
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0352052
RPL12 ribosomal protein L12 0.034871
NDRG1 N-myc downstream regulated 1 0.0333353
RPS27 ribosomal protein S27 0.0321098
RACK1 receptor for activated C kinase 1 0.0320908
MBNL2 muscleblind-like splicing regulator 2 0.0319339
LDHA lactate dehydrogenase A 0.0318891
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0311715
RPS14 ribosomal protein S14 0.0292728
APOE apolipoprotein E 0.028954
RPL5 ribosomal protein L5 0.0287997
KLF6 Kruppel-like factor 6 0.0270504
RPLP0 ribosomal protein, large, P0 0.027026
RPS29 ribosomal protein S29 0.0260511
RPL26 ribosomal protein L26 0.0256096
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0248407
LCN2 lipocalin 2 0.0248171
INTS6 integrator complex subunit 6 0.0247843
RPS24 ribosomal protein S24 0.0247146
OSBPL8 oxysterol binding protein-like 8 0.02446
RPL7 ribosomal protein L7 0.0243755
RPL35A ribosomal protein L35a 0.0243095
RPS23 ribosomal protein S23 0.0229442
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0229003
RPLP2 ribosomal protein, large, P2 0.0228365
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0224676
FAM107B family with sequence similarity 107, member B 0.0223698
NACA nascent polypeptide-associated complex alpha subunit 0.0222471
EIF1 eukaryotic translation initiation factor 1 0.0222235
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.021942
RPS27A ribosomal protein S27a 0.0211315
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0209459
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0204397
RPL37 ribosomal protein L37 0.0196783
CCL20 chemokine (C-C motif) ligand 20 0.0195231
CFB complement factor B 0.0192639
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0191926
RPS5 ribosomal protein S5 0.0191711
RPL10A ribosomal protein L10a 0.019127
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0191132
CUL3 cullin 3 0.0190483
RPL35 ribosomal protein L35 0.0187598
ATP5F1E ATP synthase F1 subunit epsilon 0.0186945
PTMA prothymosin, alpha 0.0186353
CPE carboxypeptidase E 0.0182915
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0178808
HLA-A major histocompatibility complex, class I, A 0.0178648
FTH1 ferritin, heavy polypeptide 1 0.0176601
UQCRB ubiquinol-cytochrome c reductase binding protein 0.017603
ROMO1 reactive oxygen species modulator 1 0.0175649
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0174817
RPL38 ribosomal protein L38 0.0171973
RPL27 ribosomal protein L27 0.0171039
NIPBL Nipped-B homolog (Drosophila) 0.0168748
ITGB5 integrin, beta 5 0.0168496
FERMT2 fermitin family member 2 0.0167713
SIK3 SIK family kinase 3 0.0166963
IER2 immediate early response 2 0.016554
RPS11 ribosomal protein S11 0.0165154
TOP1 topoisomerase (DNA) I 0.0165034
RPL18 ribosomal protein L18 0.0164707
KIF21A kinesin family member 21A 0.0163082
RPLP1 ribosomal protein, large, P1 0.0162633
RPL34 ribosomal protein L34 0.0162521
AGO2 argonaute RISC catalytic component 2 0.0162298
BCL2L1 BCL2-like 1 0.016205

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.187765
AKAP12 A kinase (PRKA) anchor protein 12 -0.155754
NPAS2 neuronal PAS domain protein 2 -0.0860582
ZMYND8 zinc finger, MYND-type containing 8 -0.0821714
FNDC3B fibronectin type III domain containing 3B -0.0788395
MAML2 mastermind-like 2 (Drosophila) -0.0743561
TMEM123 transmembrane protein 123 -0.0700932
APOA2 apolipoprotein A-II -0.0686087
ASPH aspartate beta-hydroxylase -0.0627457
EHBP1 EH domain binding protein 1 -0.0626551
MSI2 musashi RNA-binding protein 2 -0.0621192
DST dystonin -0.0576262
FN1 fibronectin 1 -0.0566521
GMDS GDP-mannose 4,6-dehydratase -0.0553005
PEG3 paternally expressed 3 -0.0536129
CP ceruloplasmin (ferroxidase) -0.0535651
GPC6 glypican 6 -0.0528518
FRMD5 FERM domain containing 5 -0.0515986
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0504369
ZBTB20 zinc finger and BTB domain containing 20 -0.0480351
VCL vinculin -0.0460754
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0456925
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0452141
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0442443
SOX5 SRY (sex determining region Y)-box 5 -0.0428596
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0425706
TM4SF1 transmembrane 4 L six family member 1 -0.0424489
RNF213 ring finger protein 213 -0.0407798
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0405924
KIAA1217 KIAA1217 -0.0400793
LRMDA leucine rich melanocyte differentiation associated -0.0398481
STAU1 staufen double-stranded RNA binding protein 1 -0.0388948
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0383148
GPC3 glypican 3 -0.0382499
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0370194
H1-0 H1.0 linker histone -0.0365851
EML4 echinoderm microtubule associated protein like 4 -0.0357977
KDM3A lysine (K)-specific demethylase 3A -0.0351911
NHSL1 NHS-like 1 -0.0345444
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0344471
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0343427
FMNL2 formin-like 2 -0.03378
MX2 MX dynamin-like GTPase 2 -0.0333332
PARD3 par-3 family cell polarity regulator -0.0320905
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0314454
HMGA1 high mobility group AT-hook 1 -0.0291612
ATXN1 ataxin 1 -0.028835
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0287129
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0284137
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0282414
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.02782
FERMT1 fermitin family member 1 -0.0276686
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0270991
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0270714
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0269612
CANX calnexin -0.0269174
SDC4 syndecan 4 -0.0268637
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0258961
TPM4 tropomyosin 4 -0.0256582
RIGI RNA sensor RIG-I -0.025119
PTK2 protein tyrosine kinase 2 -0.0246182
ARFGEF3 ARFGEF family member 3 -0.0244818
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.024223
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0241743
RBM39 RNA binding motif protein 39 -0.0241393
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0239067
NPR2 natriuretic peptide receptor 2 -0.0238353
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0238095
ELL2 elongation factor, RNA polymerase II, 2 -0.0237764
PTCHD4 patched domain containing 4 -0.0235588
EXT1 exostosin glycosyltransferase 1 -0.0233624
FAT1 FAT atypical cadherin 1 -0.0232326
HMGA2 high mobility group AT-hook 2 -0.0230278
WAC WW domain containing adaptor with coiled-coil -0.0230235
ENKUR enkurin, TRPC channel interacting protein -0.0230233
TRIM26 tripartite motif containing 26 -0.0226827
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.022218
MAP4 microtubule-associated protein 4 -0.0221921
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.021704
CNKSR3 CNKSR family member 3 -0.0217029
CUX1 cut-like homeobox 1 -0.0211961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0210682
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0210657
IFIH1 interferon induced with helicase C domain 1 -0.0210585
EPAS1 endothelial PAS domain protein 1 -0.021002
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0209324
MRTFA myocardin related transcription factor A -0.0208254
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.020711
CKAP4 cytoskeleton-associated protein 4 -0.0203267
PATJ PATJ crumbs cell polarity complex component -0.020131
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0198612
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0197567
DEK DEK proto-oncogene -0.0195838
SESTD1 SEC14 and spectrin domains 1 -0.019555
LPP LIM domain containing preferred translocation partner in lipoma -0.0195331
ACTG1 actin gamma 1 -0.0193513
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0192139
KPNB1 karyopherin (importin) beta 1 -0.0192102
PHF21A PHD finger protein 21A -0.0191943
SOX4 SRY (sex determining region Y)-box 4 -0.0188146