18β-Glycyrrhetinic acid_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.368939
B2M beta-2-microglobulin 0.169676
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.151897
ALCAM activated leukocyte cell adhesion molecule 0.118803
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0999789
LMO7 LIM domain 7 0.0999291
POTEF POTE ankyrin domain family, member F 0.0955143
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0915659
RASAL2 RAS protein activator like 2 0.084051
AKAP13 A kinase (PRKA) anchor protein 13 0.0801107
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0786862
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0772394
SLC35F3 solute carrier family 35, member F3 0.0724812
PDE4D phosphodiesterase 4D, cAMP-specific 0.0722821
MTSS1 metastasis suppressor 1 0.0712247
LDHA lactate dehydrogenase A 0.0711548
PDLIM5 PDZ and LIM domain 5 0.0694278
TPT1 tumor protein, translationally-controlled 1 0.0658371
PLS3 plastin 3 0.0647437
FTH1 ferritin, heavy polypeptide 1 0.0628026
PODXL podocalyxin-like 0.0615286
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0601451
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0574651
RCOR1 REST corepressor 1 0.056581
IFI6 interferon, alpha-inducible protein 6 0.0550399
PICALM phosphatidylinositol binding clathrin assembly protein 0.0543962
CALB1 calbindin 1, 28kDa 0.0536526
MSN moesin 0.053006
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0513629
MT2A metallothionein 2A 0.0497366
IFITM1 interferon induced transmembrane protein 1 0.0485186
PSD3 pleckstrin and Sec7 domain containing 3 0.0481304
CD44 CD44 molecule (Indian blood group) 0.0457315
TAGLN2 transgelin 2 0.0457264
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0453215
HLA-A major histocompatibility complex, class I, A 0.0448868
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.044506
TPI1 triosephosphate isomerase 1 0.0443307
PCDH1 protocadherin 1 0.0441108
ZSWIM6 zinc finger, SWIM-type containing 6 0.0436621
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0436033
DIAPH1 diaphanous-related formin 1 0.0435495
MACF1 microtubule-actin crosslinking factor 1 0.0419425
BCAR3 breast cancer anti-estrogen resistance 3 0.0410312
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.040418
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0403008
RNF217 ring finger protein 217 0.0400356
RPS3 ribosomal protein S3 0.0398065
CAV1 caveolin 1, caveolae protein, 22kDa 0.0394704
IFI27 interferon, alpha-inducible protein 27 0.0388229
SULF2 sulfatase 2 0.0385506
TSC22D1 TSC22 domain family, member 1 0.0375777
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0373156
SIK3 SIK family kinase 3 0.0371732
CDK6 cyclin-dependent kinase 6 0.03708
GRB10 growth factor receptor-bound protein 10 0.0366203
IFI44L interferon-induced protein 44-like 0.0362822
ISG15 ISG15 ubiquitin-like modifier 0.0359098
FTL ferritin, light polypeptide 0.0358023
KTN1 kinectin 1 (kinesin receptor) 0.035638
RPS17 ribosomal protein S17 0.0355969
HMGA2 high mobility group AT-hook 2 0.0355349
CSTB cystatin B (stefin B) 0.0351496
MT1E metallothionein 1E 0.0350248
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0345983
EFNA5 ephrin-A5 0.0344177
RPS12 ribosomal protein S12 0.0341989
DPYD dihydropyrimidine dehydrogenase 0.0340239
INTS6 integrator complex subunit 6 0.0335961
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0335784
ANO1 anoctamin 1, calcium activated chloride channel 0.0334557
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.031762
FLG filaggrin 0.0316388
RPS6 ribosomal protein S6 0.0315415
SAMD9 sterile alpha motif domain containing 9 0.0313784
ENO1 enolase 1, (alpha) 0.0311679
ZFP36L1 ZFP36 ring finger protein-like 1 0.0309807
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0305442
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0303738
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0301935
KLF5 Kruppel-like factor 5 (intestinal) 0.0301767
LAMC2 laminin, gamma 2 0.0300831
RPL37 ribosomal protein L37 0.0294637
EGFR epidermal growth factor receptor 0.0291315
RND3 Rho family GTPase 3 0.0290207
MDK midkine (neurite growth-promoting factor 2) 0.028977
ZMIZ1 zinc finger, MIZ-type containing 1 0.0287948
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0287657
RPL12 ribosomal protein L12 0.0274694
PTK2 protein tyrosine kinase 2 0.0274308
RABGAP1L RAB GTPase activating protein 1-like 0.0273618
HLA-B major histocompatibility complex, class I, B 0.0273258
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0273129
HSPG2 heparan sulfate proteoglycan 2 0.0270413
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0268606
TJP1 tight junction protein 1 0.026722
OXSR1 oxidative stress responsive 1 0.026663
RSAD2 radical S-adenosyl methionine domain containing 2 0.0265632
DPYSL2 dihydropyrimidinase-like 2 0.0264821
STC1 stanniocalcin 1 0.0264438

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.092295
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0895721
CEMIP cell migration inducing protein, hyaluronan binding -0.0808932
NAMPT nicotinamide phosphoribosyltransferase -0.0746773
CUL4B cullin 4B -0.0631645
RBM39 RNA binding motif protein 39 -0.0539657
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0509988
KDM3A lysine (K)-specific demethylase 3A -0.0491751
GOLGA4 golgin A4 -0.048663
CANX calnexin -0.0484394
MYOF myoferlin -0.0483772
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0478329
KIAA1217 KIAA1217 -0.0460927
OGA O-GlcNAcase -0.0455785
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0449428
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.044443
TMSB10 thymosin beta 10 -0.0436966
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0414877
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.040984
PLAT plasminogen activator, tissue -0.0405229
NPEPPS aminopeptidase puromycin sensitive -0.0386914
LMNA lamin A/C -0.0386458
COPB1 coatomer protein complex, subunit beta 1 -0.0384894
KRT17 keratin 17, type I -0.0375453
CLU clusterin -0.037446
TMSB4X thymosin beta 4, X-linked -0.0366605
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0357522
ANKRD33B ankyrin repeat domain 33B -0.0349394
HDLBP high density lipoprotein binding protein -0.0339924
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0329804
EMP1 epithelial membrane protein 1 -0.0327409
PTMA prothymosin, alpha -0.0327071
AHNAK AHNAK nucleoprotein -0.0320422
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0317801
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0310149
HM13 histocompatibility (minor) 13 -0.0307691
CALR calreticulin -0.0307459
SULF1 sulfatase 1 -0.0306152
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0305738
SDC4 syndecan 4 -0.0295678
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0291782
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0291049
CFDP1 craniofacial development protein 1 -0.0291035
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0289233
KMT2E lysine (K)-specific methyltransferase 2E -0.028624
TTC3 tetratricopeptide repeat domain 3 -0.0284618
TMEM263 transmembrane protein 263 -0.0284425
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0284199
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0283126
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0280856
NCOA3 nuclear receptor coactivator 3 -0.0279863
FOXO1 forkhead box O1 -0.0279603
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.027652
RPS21 ribosomal protein S21 -0.0273516
EFHD2 EF-hand domain family, member D2 -0.0269365
PRELID2 PRELI domain containing 2 -0.0267146
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0265553
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0264552
IFI16 interferon, gamma-inducible protein 16 -0.0263539
SEC31A SEC31 homolog A (S. cerevisiae) -0.0262062
H1-0 H1.0 linker histone -0.0257542
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.0257406
LMAN1 lectin, mannose-binding, 1 -0.0250837
GARS1 glycyl-tRNA synthetase 1 -0.0246125
PNISR PNN-interacting serine/arginine-rich protein -0.0245829
WDR26 WD repeat domain 26 -0.024336
TOP1 topoisomerase (DNA) I -0.0242944
NF1 neurofibromin 1 -0.0242582
LNPEP leucyl/cystinyl aminopeptidase -0.0240343
RAB1A RAB1A, member RAS oncogene family -0.0237342
DENND4C DENN/MADD domain containing 4C -0.0236052
COG6 component of oligomeric golgi complex 6 -0.0235616
DLG1 discs, large homolog 1 (Drosophila) -0.0234867
LIFR leukemia inhibitory factor receptor alpha -0.0232655
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0231657
MORF4L2 mortality factor 4 like 2 -0.0230732
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0230677
METTL15 methyltransferase like 15 -0.0230299
CD99 CD99 molecule -0.0229491
RLF rearranged L-myc fusion -0.0229431
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0228588
RIN2 Ras and Rab interactor 2 -0.0228386
EXOC6B exocyst complex component 6B -0.0226163
MON2 MON2 homolog (S. cerevisiae) -0.0225785
GNAS GNAS complex locus -0.0222975
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0222749
ARHGAP29 Rho GTPase activating protein 29 -0.0222298
VDAC1 voltage-dependent anion channel 1 -0.022173
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.022125
IER3 immediate early response 3 -0.0221014
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.022094
S100A10 S100 calcium binding protein A10 -0.0220874
EHBP1 EH domain binding protein 1 -0.0220263
SLC45A4 solute carrier family 45, member 4 -0.0219874
HIP1 huntingtin interacting protein 1 -0.0219654
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0219553
ACBD3 acyl-CoA binding domain containing 3 -0.0219472
CAVIN1 caveolae associated protein 1 -0.0217027
SEC24D SEC24 family member D -0.0216178