18β-Glycyrrhetinic acid_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.37803
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.164274
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.109014
LDHA lactate dehydrogenase A 0.0913083
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.081238
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0793676
NDRG1 N-myc downstream regulated 1 0.0750889
PODXL podocalyxin-like 0.0620355
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0572318
CD44 CD44 molecule (Indian blood group) 0.0557226
INTS6 integrator complex subunit 6 0.0544316
AKAP12 A kinase (PRKA) anchor protein 12 0.0529241
B2M beta-2-microglobulin 0.0527948
ZNF841 zinc finger protein 841 0.0506147
RPL23 ribosomal protein L23 0.0498
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0476653
EXT1 exostosin glycosyltransferase 1 0.0472309
SLIT2 slit homolog 2 (Drosophila) 0.0466208
RPS3 ribosomal protein S3 0.0457406
CD59 CD59 molecule, complement regulatory protein 0.0452797
BASP1 brain abundant, membrane attached signal protein 1 0.04375
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0428145
CAVIN1 caveolae associated protein 1 0.0413246
ENO1 enolase 1, (alpha) 0.0393108
RPL12 ribosomal protein L12 0.0374964
TLE4 transducin-like enhancer of split 4 0.0369257
ZSWIM6 zinc finger, SWIM-type containing 6 0.0369125
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0359194
RPS12 ribosomal protein S12 0.0338435
TUBB4B tubulin, beta 4B class IVb 0.0320742
HLA-A major histocompatibility complex, class I, A 0.0320503
TPI1 triosephosphate isomerase 1 0.0313848
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0311701
RACK1 receptor for activated C kinase 1 0.0302318
CSNK1A1 casein kinase 1, alpha 1 0.0300428
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0297475
RPL26 ribosomal protein L26 0.0287726
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0286555
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0286475
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0281894
PTPRF protein tyrosine phosphatase, receptor type, F 0.028179
NAP1L1 nucleosome assembly protein 1-like 1 0.028063
PDLIM5 PDZ and LIM domain 5 0.027962
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0275216
RPL9 ribosomal protein L9 0.025947
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.025777
SMAD3 SMAD family member 3 0.0254422
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0253193
FLNB filamin B, beta 0.024852
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0247323
FAM107B family with sequence similarity 107, member B 0.024692
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0246059
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0241035
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0240422
MBNL1 muscleblind-like splicing regulator 1 0.0239336
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0237478
IRS2 insulin receptor substrate 2 0.0235357
NACA nascent polypeptide-associated complex alpha subunit 0.0234668
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0231463
ANGPTL4 angiopoietin-like 4 0.0224317
EZR ezrin 0.0223289
BRWD1 bromodomain and WD repeat domain containing 1 0.0223206
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0221001
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0216722
RPS17 ribosomal protein S17 0.0214982
SFTPA2 surfactant protein A2 0.0213873
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0210876
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0209357
APLP2 amyloid beta (A4) precursor-like protein 2 0.0209256
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0207994
PUM1 pumilio RNA-binding family member 1 0.0206265
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0205861
RPL18 ribosomal protein L18 0.0204945
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0204623
LOX lysyl oxidase 0.0202727
GMDS GDP-mannose 4,6-dehydratase 0.0202463
CENPU centromere protein U 0.0202291
COL12A1 collagen, type XII, alpha 1 0.0201328
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0200849
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0198261
DSCAM Down syndrome cell adhesion molecule 0.0198201
ENO2 enolase 2 (gamma, neuronal) 0.0197907
DST dystonin 0.0196002
ZCCHC7 zinc finger, CCHC domain containing 7 0.019437
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0193363
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0192736
SH3RF1 SH3 domain containing ring finger 1 0.0190493
TPP2 tripeptidyl peptidase II 0.0190371
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0190292
SP100 SP100 nuclear antigen 0.0190156
EXOC4 exocyst complex component 4 0.0189247
MAPK8 mitogen-activated protein kinase 8 0.0188617
RPL37A ribosomal protein L37a 0.0188596
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0188533
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0188012
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0186316
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0186096
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0185928
SFPQ splicing factor proline/glutamine-rich 0.018506
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.018494

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.236473
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146865
NALF1 NALCN channel auxiliary factor 1 -0.143354
HLA-B major histocompatibility complex, class I, B -0.128129
ABI3BP ABI family, member 3 (NESH) binding protein -0.116216
IGFBP3 insulin-like growth factor binding protein 3 -0.110197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108814
UGCG UDP-glucose ceramide glucosyltransferase -0.107277
PDIA3 protein disulfide isomerase family A, member 3 -0.0979631
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0950945
DEK DEK proto-oncogene -0.0876768
MARCKS myristoylated alanine-rich protein kinase C substrate -0.082768
CANX calnexin -0.0684007
PTMA prothymosin, alpha -0.0664838
TPM1 tropomyosin 1 (alpha) -0.0643317
POSTN periostin, osteoblast specific factor -0.0638646
FTL ferritin, light polypeptide -0.0618294
FTH1 ferritin, heavy polypeptide 1 -0.0598011
ACTG1 actin gamma 1 -0.0583037
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0580569
DLG1 discs, large homolog 1 (Drosophila) -0.0578363
SULF1 sulfatase 1 -0.0559018
SLC12A8 solute carrier family 12, member 8 -0.0548425
PLCB4 phospholipase C, beta 4 -0.0538563
TPM4 tropomyosin 4 -0.0524953
TMSB4X thymosin beta 4, X-linked -0.0521279
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.051729
KRT7 keratin 7, type II -0.0508556
CALR calreticulin -0.0502358
GOLGA4 golgin A4 -0.0498328
SBF2 SET binding factor 2 -0.0496785
FNDC3B fibronectin type III domain containing 3B -0.0476893
F3 coagulation factor III (thromboplastin, tissue factor) -0.0448537
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.044466
CTSD cathepsin D -0.0444245
PFN1 profilin 1 -0.0443659
TRIO trio Rho guanine nucleotide exchange factor -0.0434566
MAP4 microtubule-associated protein 4 -0.0414029
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0405853
KPNB1 karyopherin (importin) beta 1 -0.0404942
POTEF POTE ankyrin domain family, member F -0.0390936
VIM vimentin -0.0377337
HMGB1 high mobility group box 1 -0.0369975
S100A6 S100 calcium binding protein A6 -0.0368673
CCDC80 coiled-coil domain containing 80 -0.036758
PHACTR1 phosphatase and actin regulator 1 -0.0363136
UBE2K ubiquitin-conjugating enzyme E2K -0.0361447
INSIG1 insulin induced gene 1 -0.0358927
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0350594
ADAM9 ADAM metallopeptidase domain 9 -0.0349746
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.034886
RHOBTB3 Rho-related BTB domain containing 3 -0.0342117
MMP12 matrix metallopeptidase 12 -0.0341089
PKM pyruvate kinase, muscle -0.0337132
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.033553
STMN1 stathmin 1 -0.0333499
TXNRD1 thioredoxin reductase 1 -0.0323999
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0319989
TUBB tubulin, beta class I -0.0314834
NPEPPS aminopeptidase puromycin sensitive -0.0311399
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0309572
CCBE1 collagen and calcium binding EGF domains 1 -0.0305307
SETD5 SET domain containing 5 -0.029918
ZMYND8 zinc finger, MYND-type containing 8 -0.0291477
S100A10 S100 calcium binding protein A10 -0.0289425
CCNL1 cyclin L1 -0.0284728
TMEM178B transmembrane protein 178B -0.0275492
WAC WW domain containing adaptor with coiled-coil -0.0274373
COPA coatomer protein complex, subunit alpha -0.0270584
RAB7A RAB7A, member RAS oncogene family -0.0270103
TPM3 tropomyosin 3 -0.0270056
MAP1B microtubule-associated protein 1B -0.0268891
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0268774
NUP153 nucleoporin 153kDa -0.0266821
UBC ubiquitin C -0.0261876
STAU1 staufen double-stranded RNA binding protein 1 -0.0257759
MYO9B myosin IXB -0.0255706
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0252686
IGFBP5 insulin-like growth factor binding protein 5 -0.0252652
RPL35A ribosomal protein L35a -0.0252375
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0251682
CUX1 cut-like homeobox 1 -0.0251424
TRAM1 translocation associated membrane protein 1 -0.024955
RAP1B RAP1B, member of RAS oncogene family -0.0249486
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0247733
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0247638
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0247236
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0246845
COL5A2 collagen, type V, alpha 2 -0.0246473
NCOR2 nuclear receptor corepressor 2 -0.0244464
MARCHF7 membrane associated ring-CH-type finger 7 -0.0243549
RPS13 ribosomal protein S13 -0.0241803
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0241186
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0238653
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0237815
NAV1 neuron navigator 1 -0.0236883
MPZL1 myelin protein zero-like 1 -0.0236678
GGNBP2 gametogenetin binding protein 2 -0.0231899
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0231216