18β-Glycyrrhetinic acid_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.182096
B2M beta-2-microglobulin 0.149684
FTL ferritin, light polypeptide 0.128361
LMO7 LIM domain 7 0.112016
FGFR2 fibroblast growth factor receptor 2 0.110937
RPL23 ribosomal protein L23 0.110287
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.105995
TMC5 transmembrane channel-like 5 0.105946
EZR ezrin 0.105878
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.099199
TMSB10 thymosin beta 10 0.0894016
S100P S100 calcium binding protein P 0.0666689
RPS3 ribosomal protein S3 0.0665692
RPS12 ribosomal protein S12 0.0660227
LCN2 lipocalin 2 0.0658752
EIF1 eukaryotic translation initiation factor 1 0.0647236
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0640153
RPS19 ribosomal protein S19 0.0639914
EMP1 epithelial membrane protein 1 0.0631941
DSPP dentin sialophosphoprotein 0.0577419
RPL12 ribosomal protein L12 0.0555942
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.053208
EPCAM epithelial cell adhesion molecule 0.0517501
ASPH aspartate beta-hydroxylase 0.0495787
ENO1 enolase 1, (alpha) 0.0482672
ANXA2 annexin A2 0.048237
LIMA1 LIM domain and actin binding 1 0.0477647
PGK1 phosphoglycerate kinase 1 0.0477067
APLP2 amyloid beta (A4) precursor-like protein 2 0.0476454
RPL18 ribosomal protein L18 0.0465933
LOC102724023 ES1 protein homolog, mitochondrial 0.0464811
HLA-A major histocompatibility complex, class I, A 0.0462054
RPL26 ribosomal protein L26 0.0460124
IFI27 interferon, alpha-inducible protein 27 0.0451564
RPS17 ribosomal protein S17 0.0447116
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0445757
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0444515
ANXA1 annexin A1 0.0444127
MYOF myoferlin 0.0414464
KLF6 Kruppel-like factor 6 0.0405674
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.039605
AGR3 anterior gradient 3 0.0395811
KRT19 keratin 19, type I 0.0394578
AKAP13 A kinase (PRKA) anchor protein 13 0.0384954
EFNA5 ephrin-A5 0.0379036
RPS27 ribosomal protein S27 0.0372877
RPL37A ribosomal protein L37a 0.0372065
IFI6 interferon, alpha-inducible protein 6 0.0369075
TUBB4B tubulin, beta 4B class IVb 0.0366908
RPL9 ribosomal protein L9 0.0366773
NCEH1 neutral cholesterol ester hydrolase 1 0.0358052
SFTPA2 surfactant protein A2 0.0355758
SEPTIN9 septin 9 0.0353687
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0352332
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.034565
ALCAM activated leukocyte cell adhesion molecule 0.0344906
IFITM1 interferon induced transmembrane protein 1 0.0343962
RPL31 ribosomal protein L31 0.0340004
TPT1 tumor protein, translationally-controlled 1 0.0337919
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0332019
IFITM3 interferon induced transmembrane protein 3 0.0328979
RPS6 ribosomal protein S6 0.0327487
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0325107
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0323868
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0317492
TXNIP thioredoxin interacting protein 0.030758
MYO1E myosin IE 0.03063
TMEM45B transmembrane protein 45B 0.0304744
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0302103
TMSB4X thymosin beta 4, X-linked 0.0298596
UBB ubiquitin B 0.0296538
FTH1 ferritin, heavy polypeptide 1 0.0291969
MBNL1 muscleblind-like splicing regulator 1 0.028818
PTPRK protein tyrosine phosphatase, receptor type, K 0.0287909
RPL11 ribosomal protein L11 0.0287498
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0287332
LAMB3 laminin, beta 3 0.0285527
FAT1 FAT atypical cadherin 1 0.0284655
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0281675
KRT18 keratin 18, type I 0.0281326
RPL35 ribosomal protein L35 0.0280754
PRRC2C proline-rich coiled-coil 2C 0.0280488
MBNL2 muscleblind-like splicing regulator 2 0.0273505
SERINC1 serine incorporator 1 0.0269548
MYO6 myosin VI 0.0266369
EXT1 exostosin glycosyltransferase 1 0.0266038
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0264166
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0263922
MYH9 myosin, heavy chain 9, non-muscle 0.0260261
NDUFA4 NDUFA4, mitochondrial complex associated 0.0258049
SQSTM1 sequestosome 1 0.0255782
LDHA lactate dehydrogenase A 0.0255574
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0249758
NAMPT nicotinamide phosphoribosyltransferase 0.0245429
SMAD3 SMAD family member 3 0.0244739
RPL19 ribosomal protein L19 0.0243479
BAIAP2L1 BAI1-associated protein 2-like 1 0.0242125
NDRG1 N-myc downstream regulated 1 0.0241648
CAVIN1 caveolae associated protein 1 0.024093
CLDN4 claudin 4 0.0240728

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.183973
GMDS GDP-mannose 4,6-dehydratase -0.069091
TMEM123 transmembrane protein 123 -0.0653469
PTMA prothymosin, alpha -0.0650579
MAML2 mastermind-like 2 (Drosophila) -0.0634305
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0570798
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0518846
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0491686
PDIA3 protein disulfide isomerase family A, member 3 -0.0490483
IARS1 isoleucyl-tRNA synthetase 1 -0.0474948
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0447952
INSIG1 insulin induced gene 1 -0.0432711
CD46 CD46 molecule, complement regulatory protein -0.0419137
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0378557
RUNX1 runt-related transcription factor 1 -0.0373952
CDK6 cyclin-dependent kinase 6 -0.0373937
ACTG1 actin gamma 1 -0.0348417
CCNL1 cyclin L1 -0.0327799
WARS1 tryptophanyl-tRNA synthetase 1 -0.0326303
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0324047
TRPS1 trichorhinophalangeal syndrome I -0.0316876
DEK DEK proto-oncogene -0.0305543
TNIK TRAF2 and NCK interacting kinase -0.0301579
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0296558
KRT7 keratin 7, type II -0.0281193
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0281191
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0277584
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0275572
BIRC6 baculoviral IAP repeat containing 6 -0.0270059
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0268559
S100A10 S100 calcium binding protein A10 -0.0267788
SRPK2 SRSF protein kinase 2 -0.0264349
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0254322
ANO1 anoctamin 1, calcium activated chloride channel -0.0250454
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.024881
TCF12 transcription factor 12 -0.0248316
SETD5 SET domain containing 5 -0.0244406
RAB6A RAB6A, member RAS oncogene family -0.0237021
S100A6 S100 calcium binding protein A6 -0.0233201
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0232675
ZNF609 zinc finger protein 609 -0.0231077
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0230563
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0228689
CAMKMT calmodulin-lysine N-methyltransferase -0.0226499
PFN1 profilin 1 -0.0225956
C6ORF132 chromosome 6 open reading frame 132 -0.0223594
POTEF POTE ankyrin domain family, member F -0.0219718
TPM4 tropomyosin 4 -0.0215947
CCND1 cyclin D1 -0.0212215
WASF2 WAS protein family, member 2 -0.0211909
ACACA acetyl-CoA carboxylase alpha -0.0204248
NFIA nuclear factor I/A -0.0203354
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0198006
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0197842
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0194688
H1-0 H1.0 linker histone -0.0194116
GNAS GNAS complex locus -0.0190912
PCDHB16 protocadherin beta 16 -0.0190309
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.018992
SMC4 structural maintenance of chromosomes 4 -0.0189659
SREBF2 sterol regulatory element binding transcription factor 2 -0.0188675
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0188014
EPSTI1 epithelial stromal interaction 1 (breast) -0.0187231
NHSL1 NHS-like 1 -0.0186726
TMPRSS4 transmembrane protease, serine 4 -0.0186597
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0186085
FASN fatty acid synthase -0.0184567
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0180026
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0179906
AGR2 anterior gradient 2 -0.0177169
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0174237
DLG1 discs, large homolog 1 (Drosophila) -0.0174236
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0174172
PRKCA protein kinase C, alpha -0.017263
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0172193
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0168962
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0168282
ARHGAP32 Rho GTPase activating protein 32 -0.0168154
SETX senataxin -0.0167676
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0166091
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0165242
CUX1 cut-like homeobox 1 -0.0164732
TAS2R14 taste receptor, type 2, member 14 -0.0164559
SRPK1 SRSF protein kinase 1 -0.0163795
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0162424
FOXK2 forkhead box K2 -0.0162255
PTK2 protein tyrosine kinase 2 -0.016176
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0161346
ARHGAP6 Rho GTPase activating protein 6 -0.0157988
KCMF1 potassium channel modulatory factor 1 -0.0157236
RAD51B RAD51 paralog B -0.0155586
TAPBP TAP binding protein (tapasin) -0.0154844
GRB10 growth factor receptor-bound protein 10 -0.0153454
CYRIB CYFIP related Rac1 interactor B -0.0152769
ANKRD17 ankyrin repeat domain 17 -0.0152535
CA2 carbonic anhydrase II -0.015252
NCOR2 nuclear receptor corepressor 2 -0.0151735
RBM39 RNA binding motif protein 39 -0.0151238
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0149622
KLHL29 kelch-like family member 29 -0.014896