18β-Glycyrrhetinic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.147957
RPL23 ribosomal protein L23 0.119589
RPS12 ribosomal protein S12 0.0936988
RPS3 ribosomal protein S3 0.0927849
RPL12 ribosomal protein L12 0.0850912
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0701338
MT2A metallothionein 2A 0.0663704
RPL37A ribosomal protein L37a 0.0586199
RPS17 ribosomal protein S17 0.0553938
RPL36 ribosomal protein L36 0.0547951
LDHA lactate dehydrogenase A 0.0539779
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0534771
EEF2 eukaryotic translation elongation factor 2 0.0519277
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0511091
RACK1 receptor for activated C kinase 1 0.0501618
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0493045
LIMA1 LIM domain and actin binding 1 0.0481508
RPS6 ribosomal protein S6 0.0473858
EIF1 eukaryotic translation initiation factor 1 0.0423094
RPL26 ribosomal protein L26 0.0400182
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0395319
IRS2 insulin receptor substrate 2 0.0385339
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0358598
LOC112694756 uncharaterized LOC112694756 0.0355983
NAMPT nicotinamide phosphoribosyltransferase 0.0348914
STC1 stanniocalcin 1 0.0344421
RPL18 ribosomal protein L18 0.0337801
RPL31 ribosomal protein L31 0.0328336
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0328181
TXNRD1 thioredoxin reductase 1 0.0321297
RPL37 ribosomal protein L37 0.0317657
EEF1G eukaryotic translation elongation factor 1 gamma 0.0315976
RPS4X ribosomal protein S4, X-linked 0.0313219
RPL7 ribosomal protein L7 0.0312963
RPS8 ribosomal protein S8 0.0310491
RPL9 ribosomal protein L9 0.029433
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289965
TXNIP thioredoxin interacting protein 0.0281523
RPS19 ribosomal protein S19 0.0276077
MBNL1 muscleblind-like splicing regulator 1 0.0272549
RPS2 ribosomal protein S2 0.0272358
GOLGA4 golgin A4 0.0261194
BRD2 bromodomain containing 2 0.0259424
KTN1 kinectin 1 (kinesin receptor) 0.0257572
NDRG1 N-myc downstream regulated 1 0.0253651
EIF4B eukaryotic translation initiation factor 4B 0.0253392
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0252425
EZR ezrin 0.0252169
PCBP2 poly(rC) binding protein 2 0.0251941
ENO1 enolase 1, (alpha) 0.0250612
MCTP1 multiple C2 domains, transmembrane 1 0.0237866
LOC102724023 ES1 protein homolog, mitochondrial 0.0234074
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0228793
YBX1 Y box binding protein 1 0.022233
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0222245
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0220842
EIF3A eukaryotic translation initiation factor 3, subunit A 0.022058
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0217277
YBX3 Y box binding protein 3 0.0216497
RPLP2 ribosomal protein, large, P2 0.0212154
NAP1L1 nucleosome assembly protein 1-like 1 0.0211577
BRWD1 bromodomain and WD repeat domain containing 1 0.0208247
SERBP1 SERPINE1 mRNA binding protein 1 0.0205379
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0204421
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0200146
RPLP1 ribosomal protein, large, P1 0.0199784
RPL4 ribosomal protein L4 0.0198325
RPL5 ribosomal protein L5 0.019799
RPS20 ribosomal protein S20 0.0196134
RPL11 ribosomal protein L11 0.0195771
EIF5B eukaryotic translation initiation factor 5B 0.0195508
RPL27 ribosomal protein L27 0.0194414
PRRC2C proline-rich coiled-coil 2C 0.019422
B2M beta-2-microglobulin 0.0192046
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0190693
ATP13A3 ATPase type 13A3 0.0190518
RPL30 ribosomal protein L30 0.018899
RPS7 ribosomal protein S7 0.0185707
MATR3 matrin 3 0.0185678
OSBPL8 oxysterol binding protein-like 8 0.0184379
ARL15 ADP-ribosylation factor-like 15 0.0184093
MYO6 myosin VI 0.0183948
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0182387
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180293
RPS27 ribosomal protein S27 0.0179885
RPL21 ribosomal protein L21 0.0179602
ZSWIM6 zinc finger, SWIM-type containing 6 0.017805
RPS14 ribosomal protein S14 0.0175068
SERINC1 serine incorporator 1 0.0174739
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0174312
HSPA8 heat shock 70kDa protein 8 0.0172817
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0171638
NBR1 neighbor of BRCA1 gene 1 0.016952
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0168947
KIF5B kinesin family member 5B 0.0168802
DUSP6 dual specificity phosphatase 6 0.0166548
FLNA filamin A, alpha 0.0165076
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.016388
APLP2 amyloid beta (A4) precursor-like protein 2 0.0162818
NEK7 NIMA-related kinase 7 0.0160913

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.194873
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.157093
GPC6 glypican 6 -0.14436
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.136243
MMP12 matrix metallopeptidase 12 -0.129616
PHACTR1 phosphatase and actin regulator 1 -0.116232
LSAMP limbic system-associated membrane protein -0.110758
TMSB10 thymosin beta 10 -0.108131
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.106784
CDH13 cadherin 13 -0.105627
NALF1 NALCN channel auxiliary factor 1 -0.0926584
NAV1 neuron navigator 1 -0.0876486
PTK2 protein tyrosine kinase 2 -0.0810228
KIAA1217 KIAA1217 -0.0758992
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0738803
KIAA1549L KIAA1549-like -0.0726671
PTMA prothymosin, alpha -0.0726236
PTPRG protein tyrosine phosphatase, receptor type, G -0.0707066
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0696036
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0694603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0680669
PBX3 pre-B-cell leukemia homeobox 3 -0.0674727
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0652707
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0621856
NTM neurotrimin -0.0620743
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0619947
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0617272
AKAP12 A kinase (PRKA) anchor protein 12 -0.0605007
VCL vinculin -0.0577642
PTCHD4 patched domain containing 4 -0.0577376
SBF2 SET binding factor 2 -0.0570896
PRKG1 protein kinase, cGMP-dependent, type I -0.0530728
ASPH aspartate beta-hydroxylase -0.0519805
EXT1 exostosin glycosyltransferase 1 -0.0519024
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0514564
TPM4 tropomyosin 4 -0.0506603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0504782
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0504552
RTN4 reticulon 4 -0.0502171
EGR1 early growth response 1 -0.0501571
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0501157
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0479048
NABP1 nucleic acid binding protein 1 -0.0476174
SAMD3 sterile alpha motif domain containing 3 -0.0467122
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0449755
MAP4 microtubule-associated protein 4 -0.0443087
SASH1 SAM and SH3 domain containing 1 -0.043214
PTPRK protein tyrosine phosphatase, receptor type, K -0.0417549
CTSB cathepsin B -0.041347
PDE4D phosphodiesterase 4D, cAMP-specific -0.039605
FN1 fibronectin 1 -0.0387899
MSR1 macrophage scavenger receptor 1 -0.0387397
C2CD2 C2 calcium-dependent domain containing 2 -0.0386869
SDCCAG8 serologically defined colon cancer antigen 8 -0.0385547
JMJD1C jumonji domain containing 1C -0.0382714
ARHGAP18 Rho GTPase activating protein 18 -0.0381781
MCL1 myeloid cell leukemia 1 -0.0378327
ANTXR2 anthrax toxin receptor 2 -0.0377445
RNF213 ring finger protein 213 -0.0367898
CDK17 cyclin-dependent kinase 17 -0.0365665
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0348605
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0347072
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.033782
TNNC1 troponin C type 1 (slow) -0.0337605
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0337007
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0331151
TAS2R14 taste receptor, type 2, member 14 -0.0330262
ACTG1 actin gamma 1 -0.0328904
ZNF804A zinc finger protein 804A -0.0326451
HMGA1 high mobility group AT-hook 1 -0.0322178
MACF1 microtubule-actin crosslinking factor 1 -0.0320789
ANXA2 annexin A2 -0.0317796
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0315931
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0312689
MBD5 methyl-CpG binding domain protein 5 -0.0310771
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0310675
RIGI RNA sensor RIG-I -0.0305952
SETD5 SET domain containing 5 -0.0305795
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0305764
ALCAM activated leukocyte cell adhesion molecule -0.0305596
BMAL2 basic helix-loop-helix ARNT like 2 -0.0304562
AHNAK AHNAK nucleoprotein -0.0303868
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.029813
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0295796
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0295171
AEBP2 AE binding protein 2 -0.029453
CUX1 cut-like homeobox 1 -0.0293711
EFNA5 ephrin-A5 -0.029213
COL27A1 collagen, type XXVII, alpha 1 -0.029001
BNC2 basonuclin 2 -0.0289883
GNAS GNAS complex locus -0.0287247
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0286433
DOCK4 dedicator of cytokinesis 4 -0.028375
DNER delta/notch-like EGF repeat containing -0.0274828
CD109 CD109 molecule -0.0271685
FNDC3B fibronectin type III domain containing 3B -0.0269019
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -0.0266457
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0266368
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0266091
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0264873