18β-Glycyrrhetinic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.172863
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.141348
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.127021
VIM vimentin 0.115297
TMSB10 thymosin beta 10 0.0996854
FTL ferritin, light polypeptide 0.0802297
POTEF POTE ankyrin domain family, member F 0.0665022
FMNL2 formin-like 2 0.0615381
RPS19 ribosomal protein S19 0.0585328
PSD3 pleckstrin and Sec7 domain containing 3 0.0568562
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0497324
TPI1 triosephosphate isomerase 1 0.0487967
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0476327
B2M beta-2-microglobulin 0.045531
ENO2 enolase 2 (gamma, neuronal) 0.0444143
ZSWIM6 zinc finger, SWIM-type containing 6 0.0436174
SMYD3 SET and MYND domain containing 3 0.0435281
DPYD dihydropyrimidine dehydrogenase 0.043348
AREG amphiregulin 0.0426755
NPAS2 neuronal PAS domain protein 2 0.0425046
CSNK1A1 casein kinase 1, alpha 1 0.0424538
OSBPL8 oxysterol binding protein-like 8 0.0409934
SON SON DNA binding protein 0.0395731
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0377371
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0376493
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0373793
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0370724
TTC3 tetratricopeptide repeat domain 3 0.0369398
ADGRG6 adhesion G protein-coupled receptor G6 0.0367119
CXCL8 chemokine (C-X-C motif) ligand 8 0.0366057
ANKRD12 ankyrin repeat domain 12 0.0355805
KTN1 kinectin 1 (kinesin receptor) 0.03499
JMJD1C jumonji domain containing 1C 0.0346835
VMP1 vacuole membrane protein 1 0.033883
TPT1 tumor protein, translationally-controlled 1 0.0329847
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0329821
RPL37A ribosomal protein L37a 0.0328271
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0326486
EXOC4 exocyst complex component 4 0.0324454
RPL12 ribosomal protein L12 0.0323558
WWTR1 WW domain containing transcription regulator 1 0.0321842
MT1X metallothionein 1X 0.0317672
ZBTB38 zinc finger and BTB domain containing 38 0.0315507
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.03137
RBM25 RNA binding motif protein 25 0.0311522
RTTN rotatin 0.0310385
RPL36 ribosomal protein L36 0.0302872
SYAP1 synapse associated protein 1 0.0298299
RPS23 ribosomal protein S23 0.0293247
RPL18 ribosomal protein L18 0.0291011
AKAP9 A kinase (PRKA) anchor protein 9 0.0290695
TOP1 topoisomerase (DNA) I 0.028911
RPS14 ribosomal protein S14 0.0288829
DSCAM Down syndrome cell adhesion molecule 0.0286634
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0284956
MCTP1 multiple C2 domains, transmembrane 1 0.0282583
INTS6 integrator complex subunit 6 0.0282042
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0279019
RCOR1 REST corepressor 1 0.0277832
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0272376
MBNL1 muscleblind-like splicing regulator 1 0.0270549
WSB1 WD repeat and SOCS box containing 1 0.0269251
FER fer (fps/fes related) tyrosine kinase 0.0267542
SDCCAG8 serologically defined colon cancer antigen 8 0.0266426
GCLM glutamate-cysteine ligase, modifier subunit 0.0266181
PTMA prothymosin, alpha 0.0256371
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0255246
SERBP1 SERPINE1 mRNA binding protein 1 0.0254949
RAB7A RAB7A, member RAS oncogene family 0.0251908
NAP1L1 nucleosome assembly protein 1-like 1 0.0251118
EIF4A1 eukaryotic translation initiation factor 4A1 0.0249944
PTPRF protein tyrosine phosphatase, receptor type, F 0.0248877
NEK10 NIMA-related kinase 10 0.0248575
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0247317
RUNX1 runt-related transcription factor 1 0.0245583
TUBB4B tubulin, beta 4B class IVb 0.0244034
PRRC2C proline-rich coiled-coil 2C 0.0242433
RPS24 ribosomal protein S24 0.0242308
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0242215
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0241558
ZFP36L1 ZFP36 ring finger protein-like 1 0.0240495
LOC102724023 ES1 protein homolog, mitochondrial 0.0240036
PUM1 pumilio RNA-binding family member 1 0.0239652
RPL19 ribosomal protein L19 0.0239075
AHI1 Abelson helper integration site 1 0.0236445
NIPBL Nipped-B homolog (Drosophila) 0.023602
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0235978
LDHA lactate dehydrogenase A 0.0235419
BRD4 bromodomain containing 4 0.023276
ZEB1 zinc finger E-box binding homeobox 1 0.0231752
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0231712
RABGAP1L RAB GTPase activating protein 1-like 0.0230404
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0229287
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0225085
THOC2 THO complex 2 0.0224966
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0224719
RAD51B RAD51 paralog B 0.0224142
FN1 fibronectin 1 0.0223385
CBX3 chromobox homolog 3 0.0222363
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0221081

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0611878
ERRFI1 ERBB receptor feedback inhibitor 1 -0.059543
TMSB4X thymosin beta 4, X-linked -0.052133
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0409301
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0344953
WARS1 tryptophanyl-tRNA synthetase 1 -0.0342846
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.029846
RPS6 ribosomal protein S6 -0.0280049
RIGI RNA sensor RIG-I -0.0272705
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0268682
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0261471
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0249959
AHNAK AHNAK nucleoprotein -0.0245432
CANX calnexin -0.0241908
IFIH1 interferon induced with helicase C domain 1 -0.0235127
ANKRD11 ankyrin repeat domain 11 -0.023003
CADM2 cell adhesion molecule 2 -0.0224321
KPNB1 karyopherin (importin) beta 1 -0.0222618
ZMYND8 zinc finger, MYND-type containing 8 -0.0216507
SDK1 sidekick cell adhesion molecule 1 -0.0206838
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0204422
CFLAR CASP8 and FADD-like apoptosis regulator -0.0203379
FTH1 ferritin, heavy polypeptide 1 -0.0202079
NIBAN2 niban apoptosis regulator 2 -0.0199313
ZNF217 zinc finger protein 217 -0.0198873
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0198349
KCNK5 potassium channel, two pore domain subfamily K, member 5 -0.0196163
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0195187
TNS3 tensin 3 -0.0189284
DOCK11 dedicator of cytokinesis 11 -0.0184032
PYGL phosphorylase, glycogen, liver -0.0182374
AHNAK2 AHNAK nucleoprotein 2 -0.0182211
HOOK2 hook microtubule-tethering protein 2 -0.0179212
FERMT1 fermitin family member 1 -0.0176225
APP amyloid beta (A4) precursor protein -0.017515
NT5E 5'-nucleotidase, ecto (CD73) -0.0173135
PRRC2B proline-rich coiled-coil 2B -0.0172712
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0167012
RPS20 ribosomal protein S20 -0.0166371
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0165319
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.016085
MXI1 MAX interactor 1, dimerization protein -0.0160337
RTN4 reticulon 4 -0.0160097
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0158707
SOD2 superoxide dismutase 2, mitochondrial -0.015747
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0150481
KIAA1958 KIAA1958 -0.0147606
YEATS2 YEATS domain containing 2 -0.0147206
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0146932
HLA-B major histocompatibility complex, class I, B -0.0146137
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0145711
RAB27B RAB27B, member RAS oncogene family -0.0143828
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0143393
HSPA8 heat shock 70kDa protein 8 -0.0143341
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0142915
RPL13A ribosomal protein L13a -0.0142285
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0139008
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0138679
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.013564
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0133848
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0130947
EZR ezrin -0.0130495
HLA-E major histocompatibility complex, class I, E -0.0130058
ADAM17 ADAM metallopeptidase domain 17 -0.0129306
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0127786
HILPDA hypoxia inducible lipid droplet-associated -0.0126279
ZBTB25 zinc finger and BTB domain containing 25 -0.0125952
PYGB phosphorylase, glycogen; brain -0.0124783
FBXO17 F-box protein 17 -0.0124716
LRRC49 leucine rich repeat containing 49 -0.0123912
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0123738
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0123649
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0123504
HMOX1 heme oxygenase 1 -0.0123484
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0122431
RSRC2 arginine/serine-rich coiled-coil 2 -0.0120157
KDM4B lysine (K)-specific demethylase 4B -0.0120095
HMGB1 high mobility group box 1 -0.0119978
TMEM170A transmembrane protein 170A -0.0118056
RPL6 ribosomal protein L6 -0.0117295
MATR3 matrin 3 -0.0117196
TPM3 tropomyosin 3 -0.0117103
RNF149 ring finger protein 149 -0.0116253
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0114438
CAVIN1 caveolae associated protein 1 -0.0113929
DTX3L deltex 3 like, E3 ubiquitin ligase -0.011384
FBXO33 F-box protein 33 -0.0113773
HLA-C major histocompatibility complex, class I, C -0.0112928
NAV2 neuron navigator 2 -0.0112074
ZNF721 zinc finger protein 721 -0.011166
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0111033
MVP major vault protein -0.011087
RPLP1 ribosomal protein, large, P1 -0.0110729
ZNFX1 zinc finger, NFX1-type containing 1 -0.0110635
AARS1 alanyl-tRNA synthetase 1 -0.0110045
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0109587
NLN neurolysin (metallopeptidase M3 family) -0.0108589
RAP2B RAP2B, member of RAS oncogene family -0.0108583
TRIM38 tripartite motif containing 38 -0.0108233
PPA2 pyrophosphatase (inorganic) 2 -0.0107929