18β-Glycyrrhetinic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.221636
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.132461
EGR1 early growth response 1 0.0964188
MT2A metallothionein 2A 0.0906575
YBX3 Y box binding protein 3 0.0894679
RPS3 ribosomal protein S3 0.0892495
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.079784
TMSB10 thymosin beta 10 0.0706829
POTEF POTE ankyrin domain family, member F 0.0681171
RPL37A ribosomal protein L37a 0.066289
RAD51B RAD51 paralog B 0.0635095
AFF3 AF4/FMR2 family, member 3 0.0630898
MCL1 myeloid cell leukemia 1 0.0630094
IFI6 interferon, alpha-inducible protein 6 0.0574688
HLA-B major histocompatibility complex, class I, B 0.0557875
RPS12 ribosomal protein S12 0.0547746
TPI1 triosephosphate isomerase 1 0.0524887
RPL37 ribosomal protein L37 0.0410918
STC1 stanniocalcin 1 0.0395854
SFPQ splicing factor proline/glutamine-rich 0.0391121
AEBP2 AE binding protein 2 0.0388359
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0372119
PCBP2 poly(rC) binding protein 2 0.0363292
RPS17 ribosomal protein S17 0.0362964
VIM vimentin 0.0361586
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0356395
RPL9 ribosomal protein L9 0.0348166
RPL23 ribosomal protein L23 0.0338482
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0326852
RIMS2 regulating synaptic membrane exocytosis 2 0.0313299
TPT1 tumor protein, translationally-controlled 1 0.0313127
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0307774
TUBA1B tubulin, alpha 1b 0.0305642
HLA-A major histocompatibility complex, class I, A 0.029513
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.029378
PRH1 proline-rich protein HaeIII subfamily 1 0.0284953
BRD2 bromodomain containing 2 0.0282464
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0282377
EGFR epidermal growth factor receptor 0.0276263
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0273454
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272694
EIF5B eukaryotic translation initiation factor 5B 0.0268841
RPS19 ribosomal protein S19 0.0268254
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0265796
ACTN1 actinin, alpha 1 0.0259238
RPS8 ribosomal protein S8 0.0258665
WWOX WW domain containing oxidoreductase 0.0257477
PFN1 profilin 1 0.0256843
RPL11 ribosomal protein L11 0.0255998
RPS14 ribosomal protein S14 0.0255399
RAB7A RAB7A, member RAS oncogene family 0.0254349
TUBB4B tubulin, beta 4B class IVb 0.0252893
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0249627
RPS27 ribosomal protein S27 0.0247898
HMGA2 high mobility group AT-hook 2 0.0242368
BRD4 bromodomain containing 4 0.0242023
RPL27 ribosomal protein L27 0.0241318
OSMR oncostatin M receptor 0.0241028
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0240649
RPL31 ribosomal protein L31 0.0239768
B2M beta-2-microglobulin 0.0239452
ZSWIM6 zinc finger, SWIM-type containing 6 0.0238343
AKAP9 A kinase (PRKA) anchor protein 9 0.0238343
C6ORF62 chromosome 6 open reading frame 62 0.0238063
RPS4X ribosomal protein S4, X-linked 0.0238038
SRSF5 serine/arginine-rich splicing factor 5 0.0237974
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0237639
RPL36 ribosomal protein L36 0.0236899
ATXN1 ataxin 1 0.0236239
EIF5 eukaryotic translation initiation factor 5 0.0234723
MSN moesin 0.0232874
RPL26 ribosomal protein L26 0.0232048
DOCK5 dedicator of cytokinesis 5 0.0229238
NDRG1 N-myc downstream regulated 1 0.0228136
ACTG1 actin gamma 1 0.0222714
S100A11 S100 calcium binding protein A11 0.0208699
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0206977
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0205541
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0203561
THSD4 thrombospondin, type I, domain containing 4 0.020074
TAPBP TAP binding protein (tapasin) 0.019904
SEM1 SEM1 26S proteasome subunit 0.0198779
POMP proteasome maturation protein 0.0192718
PDE4D phosphodiesterase 4D, cAMP-specific 0.0192021
BPTF bromodomain PHD finger transcription factor 0.0190961
NTSR1 neurotensin receptor 1 (high affinity) 0.0187706
INTS6 integrator complex subunit 6 0.0186569
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0186271
NLGN1 neuroligin 1 0.0185409
RPL35A ribosomal protein L35a 0.018524
TPM2 tropomyosin 2 (beta) 0.0182849
FMNL2 formin-like 2 0.0180219
CCNL1 cyclin L1 0.0179497
RPS13 ribosomal protein S13 0.0179483
HDGF hepatoma-derived growth factor 0.0179431
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0177298
IER2 immediate early response 2 0.0175937
ENO2 enolase 2 (gamma, neuronal) 0.0175776
KMT2D lysine (K)-specific methyltransferase 2D 0.0173096
TCIM transcriptional and immune response regulator 0.0171306

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.135224
TXNRD1 thioredoxin reductase 1 -0.120752
TFPI2 tissue factor pathway inhibitor 2 -0.119641
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0927815
GRAMD1B GRAM domain containing 1B -0.0685901
OGA O-GlcNAcase -0.067281
KDM3A lysine (K)-specific demethylase 3A -0.0656422
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0593345
XPO1 exportin 1 -0.0582537
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0570909
CCND2 cyclin D2 -0.0537672
PTMA prothymosin, alpha -0.0534602
H1-0 H1.0 linker histone -0.0510991
AHNAK AHNAK nucleoprotein -0.0502767
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0492874
PHIP pleckstrin homology domain interacting protein -0.0491074
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0478037
CANX calnexin -0.047078
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0466283
BBX bobby sox homolog (Drosophila) -0.0458256
UBE2H ubiquitin-conjugating enzyme E2H -0.0433759
TRIO trio Rho guanine nucleotide exchange factor -0.0429051
GNAS GNAS complex locus -0.0426799
PGK1 phosphoglycerate kinase 1 -0.0421343
CSDE1 cold shock domain containing E1, RNA-binding -0.0418576
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0418089
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0416038
RBM39 RNA binding motif protein 39 -0.0408356
ZFR zinc finger RNA binding protein -0.0405356
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0399197
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.039049
SINHCAF SIN3-HDAC complex associated factor -0.0374848
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0373157
ZFAND3 zinc finger, AN1-type domain 3 -0.0372133
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0356261
RAD21 RAD21 homolog (S. pombe) -0.0354796
RTN4 reticulon 4 -0.0349759
MARCHF6 membrane associated ring-CH-type finger 6 -0.034899
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0347862
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0344064
APP amyloid beta (A4) precursor protein -0.032767
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0326294
EML4 echinoderm microtubule associated protein like 4 -0.0320419
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0319215
KMT2A lysine (K)-specific methyltransferase 2A -0.0315526
ADGRG6 adhesion G protein-coupled receptor G6 -0.0310444
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0309855
NIPBL Nipped-B homolog (Drosophila) -0.0308635
TLK1 tousled-like kinase 1 -0.0305288
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0298667
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0297382
MORF4L2 mortality factor 4 like 2 -0.029585
RAB10 RAB10, member RAS oncogene family -0.0293328
SRPK2 SRSF protein kinase 2 -0.0289403
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0287324
ADAR adenosine deaminase, RNA-specific -0.028654
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0282072
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0282003
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0281616
STAU1 staufen double-stranded RNA binding protein 1 -0.0279559
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0278867
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0278718
KIF5B kinesin family member 5B -0.0275973
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0275247
KCMF1 potassium channel modulatory factor 1 -0.027443
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0274249
EIF4B eukaryotic translation initiation factor 4B -0.0274223
PHF21A PHD finger protein 21A -0.0274032
MEMO1 mediator of cell motility 1 -0.0270674
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0269406
NCOR1 nuclear receptor corepressor 1 -0.02682
TMEM123 transmembrane protein 123 -0.026807
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0265018
UBE2K ubiquitin-conjugating enzyme E2K -0.0262663
SPAG9 sperm associated antigen 9 -0.0262513
GATAD2B GATA zinc finger domain containing 2B -0.0261385
SEPTIN7 septin 7 -0.0261044
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0256717
ANXA2 annexin A2 -0.0253581
ZNF217 zinc finger protein 217 -0.0251057
ATXN2 ataxin 2 -0.0250275
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0247998
MED13L mediator complex subunit 13-like -0.0246502
RASAL2 RAS protein activator like 2 -0.0246476
TUBB tubulin, beta class I -0.0246099
FBXO11 F-box protein 11 -0.0244266
NPEPPS aminopeptidase puromycin sensitive -0.0242733
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0242597
TRIM33 tripartite motif containing 33 -0.0239485
PDIA4 protein disulfide isomerase family A, member 4 -0.0239295
TAS2R14 taste receptor, type 2, member 14 -0.0236869
BRWD1 bromodomain and WD repeat domain containing 1 -0.023595
DENND5B DENN/MADD domain containing 5B -0.023529
IGF1R insulin-like growth factor 1 receptor -0.0233936
WNK1 WNK lysine deficient protein kinase 1 -0.0232786
BRWD3 bromodomain and WD repeat domain containing 3 -0.0232771
RHEB Ras homolog enriched in brain -0.0232725
TAOK1 TAO kinase 1 -0.0232555
CDYL chromodomain protein, Y-like -0.0230536
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0229707