18β-Glycyrrhetinic acid_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.1691
VIM vimentin 0.134991
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114185
RPS6 ribosomal protein S6 0.107091
PSD3 pleckstrin and Sec7 domain containing 3 0.104846
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.100476
RPS12 ribosomal protein S12 0.0993414
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0958822
COL5A2 collagen, type V, alpha 2 0.0889459
RPL37A ribosomal protein L37a 0.0880164
MT2A metallothionein 2A 0.0823407
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0784444
RPL31 ribosomal protein L31 0.0760466
RPS3 ribosomal protein S3 0.0728825
RPL23 ribosomal protein L23 0.0725426
RPS8 ribosomal protein S8 0.0720114
FN1 fibronectin 1 0.0671595
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0665673
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0663277
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0653239
MAML3 mastermind-like 3 (Drosophila) 0.0625996
RPLP1 ribosomal protein, large, P1 0.0618928
RPL12 ribosomal protein L12 0.0609705
MFF mitochondrial fission factor 0.0609172
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0588297
PRKN parkin RBR E3 ubiquitin protein ligase 0.0574354
RPL26 ribosomal protein L26 0.0546225
EFNA5 ephrin-A5 0.0544651
GDA guanine deaminase 0.0523743
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0513198
RPS19 ribosomal protein S19 0.0509457
EIF1 eukaryotic translation initiation factor 1 0.0503201
TMSB10 thymosin beta 10 0.049306
RAB3B RAB3B, member RAS oncogene family 0.0476617
RPS17 ribosomal protein S17 0.0476567
RPL36A ribosomal protein L36a 0.04736
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0472631
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0460941
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0445589
RPL9 ribosomal protein L9 0.0439829
RPL36 ribosomal protein L36 0.0439495
RPL19 ribosomal protein L19 0.0435656
RPS27 ribosomal protein S27 0.0432953
B2M beta-2-microglobulin 0.0431025
HLA-A major histocompatibility complex, class I, A 0.041507
RPL37 ribosomal protein L37 0.0411485
DOCK5 dedicator of cytokinesis 5 0.0398722
CD109 CD109 molecule 0.0392872
RPS14 ribosomal protein S14 0.0391871
RPL7A ribosomal protein L7a 0.0389346
FTL ferritin, light polypeptide 0.0381162
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0378351
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0370867
RPS25 ribosomal protein S25 0.0369781
PTMA prothymosin, alpha 0.0368333
SOX4 SRY (sex determining region Y)-box 4 0.0367206
RPLP0 ribosomal protein, large, P0 0.03672
CTSC cathepsin C 0.0365368
RACK1 receptor for activated C kinase 1 0.0364713
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0360269
TFPI2 tissue factor pathway inhibitor 2 0.0354651
NEK7 NIMA-related kinase 7 0.0352805
RPL35A ribosomal protein L35a 0.0352379
RPL11 ribosomal protein L11 0.0341068
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0340707
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0340055
PDLIM5 PDZ and LIM domain 5 0.0339563
PYGL phosphorylase, glycogen, liver 0.0336801
EEF2 eukaryotic translation elongation factor 2 0.0335735
KIAA0825 KIAA0825 0.0334194
RPS23 ribosomal protein S23 0.0334115
RPS29 ribosomal protein S29 0.0331911
ENO1 enolase 1, (alpha) 0.0325809
RPS27A ribosomal protein S27a 0.0325623
TGFBI transforming growth factor, beta-induced, 68kDa 0.0321008
ANTXR1 anthrax toxin receptor 1 0.0319461
BCAS3 breast carcinoma amplified sequence 3 0.0316894
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0315507
RPLP2 ribosomal protein, large, P2 0.0313316
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0311663
COL8A1 collagen, type VIII, alpha 1 0.0309344
GRAMD1B GRAM domain containing 1B 0.0308601
TPT1 tumor protein, translationally-controlled 1 0.0305168
PCBP2 poly(rC) binding protein 2 0.0301569
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0295501
CDK6 cyclin-dependent kinase 6 0.0294993
RPL30 ribosomal protein L30 0.0294761
RTN1 reticulon 1 0.0291094
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0290888
RGS2 regulator of G-protein signaling 2 0.0287928
MSN moesin 0.0286533
POTEF POTE ankyrin domain family, member F 0.0286261
RPS13 ribosomal protein S13 0.0284577
P3H2 prolyl 3-hydroxylase 2 0.0284427
GPRIN3 GPRIN family member 3 0.0283301
IGFBP3 insulin-like growth factor binding protein 3 0.0278557
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0276588
LDHA lactate dehydrogenase A 0.0274109
ADGRD1 adhesion G protein-coupled receptor D1 0.0270468
NALF1 NALCN channel auxiliary factor 1 0.0270318

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.190883
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.187253
SPAG9 sperm associated antigen 9 -0.0984366
CANX calnexin -0.0666601
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0626135
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0623785
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0576725
TRIO trio Rho guanine nucleotide exchange factor -0.0563986
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0553692
NBEAL1 neurobeachin-like 1 -0.0494194
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0453944
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.045094
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0450668
ESYT2 extended synaptotagmin-like protein 2 -0.04409
SOD2 superoxide dismutase 2, mitochondrial -0.043476
CTBP2 C-terminal binding protein 2 -0.0412093
BIRC6 baculoviral IAP repeat containing 6 -0.0396219
KDM3A lysine (K)-specific demethylase 3A -0.0396089
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0394998
COPA coatomer protein complex, subunit alpha -0.0394495
KMT2C lysine (K)-specific methyltransferase 2C -0.0388621
MON2 MON2 homolog (S. cerevisiae) -0.0386868
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0376747
SEC31A SEC31 homolog A (S. cerevisiae) -0.0371937
LIMCH1 LIM and calponin homology domains 1 -0.0368666
UBAP2L ubiquitin associated protein 2-like -0.0356476
OGA O-GlcNAcase -0.0355706
FNIP1 folliculin interacting protein 1 -0.0353745
FNDC3B fibronectin type III domain containing 3B -0.0350937
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0333461
FAM13A family with sequence similarity 13, member A -0.0322712
MORF4L2 mortality factor 4 like 2 -0.0317543
CAMTA1 calmodulin binding transcription activator 1 -0.0315083
DNER delta/notch-like EGF repeat containing -0.030617
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0305668
HELZ helicase with zinc finger -0.0300572
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0299463
NBAS neuroblastoma amplified sequence -0.029938
SUCO SUN domain containing ossification factor -0.0297215
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0295849
TRA2A transformer 2 alpha homolog (Drosophila) -0.0289358
RBM39 RNA binding motif protein 39 -0.0289302
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0283292
PDIA4 protein disulfide isomerase family A, member 4 -0.0282593
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0280318
AFF4 AF4/FMR2 family, member 4 -0.0278034
FNDC3A fibronectin type III domain containing 3A -0.0276223
USP34 ubiquitin specific peptidase 34 -0.0276147
BZW1 basic leucine zipper and W2 domains 1 -0.0275631
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0274925
HBP1 HMG-box transcription factor 1 -0.0274218
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0272103
TENT5A terminal nucleotidyltransferase 5A -0.0270366
GRB10 growth factor receptor-bound protein 10 -0.0270165
AGTPBP1 ATP/GTP binding protein 1 -0.0269448
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.026935
TMEM135 transmembrane protein 135 -0.0269279
GOLGA4 golgin A4 -0.0260492
NUP58 nucleoporin 58 -0.025906
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0256205
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0251787
IARS1 isoleucyl-tRNA synthetase 1 -0.025151
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0250321
RRBP1 ribosome binding protein 1 -0.0249791
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0246406
SEC24D SEC24 family member D -0.0244395
ARF1 ADP-ribosylation factor 1 -0.0241457
KDM6A lysine (K)-specific demethylase 6A -0.024019
SEC24A SEC24 family member A -0.0237456
ACVR1 activin A receptor, type I -0.0237077
MYOF myoferlin -0.023631
RIGI RNA sensor RIG-I -0.0234231
IFIH1 interferon induced with helicase C domain 1 -0.0233492
ZNF638 zinc finger protein 638 -0.0229487
RAB1A RAB1A, member RAS oncogene family -0.0228053
ELL2 elongation factor, RNA polymerase II, 2 -0.0222858
WDR45B WD repeat domain 45B -0.0221815
USP36 ubiquitin specific peptidase 36 -0.0221475
LAMA1 laminin, alpha 1 -0.0220861
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0220547
NDRG1 N-myc downstream regulated 1 -0.0219797
HM13 histocompatibility (minor) 13 -0.0218743
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0217821
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0216131
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0215863
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0215075
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0214829
USP3 ubiquitin specific peptidase 3 -0.0214058
FMNL2 formin-like 2 -0.0213128
TFG TRK-fused gene -0.0212957
SQSTM1 sequestosome 1 -0.0212014
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0211577
USP9X ubiquitin specific peptidase 9, X-linked -0.0210953
KMT2E lysine (K)-specific methyltransferase 2E -0.0210129
DENND1A DENN/MADD domain containing 1A -0.020955
INTS6 integrator complex subunit 6 -0.0207822
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0207676
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0207022
UBC ubiquitin C -0.0206945
USP37 ubiquitin specific peptidase 37 -0.0205228