18β-Glycyrrhetinic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

190 genes differentially expressed following the 18β-Glycyrrhetinic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.209773
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.158932
ANKRD12 ankyrin repeat domain 12 0.152053
EGFR epidermal growth factor receptor 0.143922
SLTM SAFB-like, transcription modulator 0.140197
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.136568
HDAC9 histone deacetylase 9 0.123957
PCDH7 protocadherin 7 0.122144
ELL2 elongation factor, RNA polymerase II, 2 0.112773
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.108799
PRELID2 PRELI domain containing 2 0.100781
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.100382
NDRG1 N-myc downstream regulated 1 0.0995096
RAD51B RAD51 paralog B 0.0932665
MYO1E myosin IE 0.0890309
CCSER1 coiled-coil serine-rich protein 1 0.0887717
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0872268
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0852245
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0833882
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0816009
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0752881
THSD4 thrombospondin, type I, domain containing 4 0.0752221
TMEM165 transmembrane protein 165 0.0720911
SETX senataxin 0.0717453
NALF1 NALCN channel auxiliary factor 1 0.0681524
JARID2 jumonji, AT rich interactive domain 2 0.0674723
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0666559
NAMPT nicotinamide phosphoribosyltransferase 0.0648806
CD44 CD44 molecule (Indian blood group) 0.0630618
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0630316
ZFAND3 zinc finger, AN1-type domain 3 0.0628083
B2M beta-2-microglobulin 0.0627356
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0612768
INTS6 integrator complex subunit 6 0.0602591
STC1 stanniocalcin 1 0.057472
CCNI cyclin I 0.0568994
SPAG9 sperm associated antigen 9 0.0566221
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0552552
DIAPH2 diaphanous-related formin 2 0.0536979
PTK2 protein tyrosine kinase 2 0.0534026
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0523422
OSMR oncostatin M receptor 0.0515373
MAP1B microtubule-associated protein 1B 0.0511193
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.050444
HM13 histocompatibility (minor) 13 0.0493228
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0477991
SBF2 SET binding factor 2 0.0436844
GRB10 growth factor receptor-bound protein 10 0.0420048
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0419506
AKAP12 A kinase (PRKA) anchor protein 12 0.0409949
KMT2C lysine (K)-specific methyltransferase 2C 0.0408106
PDE4D phosphodiesterase 4D, cAMP-specific 0.0397461
EFNA5 ephrin-A5 0.0380655
EXT1 exostosin glycosyltransferase 1 0.0343548
COL6A1 collagen, type VI, alpha 1 0.0338376
MED13L mediator complex subunit 13-like 0.0330913
ADAM10 ADAM metallopeptidase domain 10 0.0330899
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0310362
MED13 mediator complex subunit 13 0.0305633
ATXN1 ataxin 1 0.029386
RUNX1 runt-related transcription factor 1 0.0292641
FLNB filamin B, beta 0.0289959
ANXA2 annexin A2 0.028472
PKM pyruvate kinase, muscle 0.0263765
ESYT2 extended synaptotagmin-like protein 2 0.0249148
NF1 neurofibromin 1 0.0220974
GSK3B glycogen synthase kinase 3 beta 0.0198665
LOXL2 lysyl oxidase-like 2 0.019553
ENO1 enolase 1, (alpha) 0.0195085
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0180436
CUX1 cut-like homeobox 1 0.0177627
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0151172
PDE10A phosphodiesterase 10A 0.0150286
DSCAM Down syndrome cell adhesion molecule 0.0143518
NAV1 neuron navigator 1 0.0142322
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0139908
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0122416
LMO7 LIM domain 7 0.0120406
MAML3 mastermind-like 3 (Drosophila) 0.0120159
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0115436
USP34 ubiquitin specific peptidase 34 0.0113963
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0110006
DST dystonin 0.0104243
WDFY3 WD repeat and FYVE domain containing 3 0.00989164
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.00914307
DLG1 discs, large homolog 1 (Drosophila) 0.00738675
ZBTB20 zinc finger and BTB domain containing 20 0.00691282
TOR1AIP2 torsin A interacting protein 2 0.00683693
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00681735
HLA-B major histocompatibility complex, class I, B 0.00634499
FNDC3B fibronectin type III domain containing 3B 0.00596873
NRXN3 neurexin 3 0.00530295
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.00400057
SLC38A1 solute carrier family 38, member 1 0.00335245
COL6A3 collagen, type VI, alpha 3 0.00333424
MT2A metallothionein 2A 0.00231945
GOLGA4 golgin A4 0.00160394
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00135305
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.97241E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.186264
NKD1 naked cuticle homolog 1 (Drosophila) -0.163667
VIM vimentin -0.13849
TMSB10 thymosin beta 10 -0.118439
MACF1 microtubule-actin crosslinking factor 1 -0.11484
MCL1 myeloid cell leukemia 1 -0.113567
RPS8 ribosomal protein S8 -0.108407
RPS16 ribosomal protein S16 -0.108365
RPL35A ribosomal protein L35a -0.104865
PTMA prothymosin, alpha -0.102992
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0906266
SNX9 sorting nexin 9 -0.0880761
ITGA6 integrin, alpha 6 -0.0856504
PSD3 pleckstrin and Sec7 domain containing 3 -0.0841397
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0818503
MYOF myoferlin -0.0783911
NAV2 neuron navigator 2 -0.0768557
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.076493
WASF2 WAS protein family, member 2 -0.0761435
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0726473
STAG2 stromal antigen 2 -0.0720869
EEF2 eukaryotic translation elongation factor 2 -0.0697898
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0670216
RPLP2 ribosomal protein, large, P2 -0.0666232
RPLP1 ribosomal protein, large, P1 -0.0606699
SRRM2 serine/arginine repetitive matrix 2 -0.0605721
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0581376
UBC ubiquitin C -0.0555491
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0554033
RPL26 ribosomal protein L26 -0.0547088
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.054287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0535581
RPS12 ribosomal protein S12 -0.0534792
FTH1 ferritin, heavy polypeptide 1 -0.0512615
CDH13 cadherin 13 -0.051149
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0511064
DOCK4 dedicator of cytokinesis 4 -0.0506493
MAML2 mastermind-like 2 (Drosophila) -0.0487125
MYO5B myosin VB -0.0466077
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0436547
PGK1 phosphoglycerate kinase 1 -0.0428695
RPL11 ribosomal protein L11 -0.0428668
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.041395
JMJD1C jumonji domain containing 1C -0.0401487
CEMIP cell migration inducing protein, hyaluronan binding -0.0389622
FTL ferritin, light polypeptide -0.0381331
AHNAK AHNAK nucleoprotein -0.037638
TPT1 tumor protein, translationally-controlled 1 -0.0366421
NAP1L1 nucleosome assembly protein 1-like 1 -0.0365941
FN1 fibronectin 1 -0.0342348
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0324486
CARD16 caspase recruitment domain family, member 16 -0.0315004
MAP4 microtubule-associated protein 4 -0.0299903
BIRC6 baculoviral IAP repeat containing 6 -0.0296708
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0288336
TRIO trio Rho guanine nucleotide exchange factor -0.0270513
GPC6 glypican 6 -0.0267943
LAMB3 laminin, beta 3 -0.0267691
LDHA lactate dehydrogenase A -0.0257076
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0246289
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0235348
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0220185
WSB1 WD repeat and SOCS box containing 1 -0.0217624
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0210258
IGFBP3 insulin-like growth factor binding protein 3 -0.0209565
POTEF POTE ankyrin domain family, member F -0.020652
RPS6 ribosomal protein S6 -0.0203562
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0194678
SAMD4A sterile alpha motif domain containing 4A -0.019362
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0174776
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0170556
GMDS GDP-mannose 4,6-dehydratase -0.0167453
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.016523
DOCK5 dedicator of cytokinesis 5 -0.014381
RPL19 ribosomal protein L19 -0.0125638
RBM25 RNA binding motif protein 25 -0.012383
EZR ezrin -0.0120168
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0110292
FMNL2 formin-like 2 -0.0105614
TXNRD1 thioredoxin reductase 1 -0.00981623
S100A9 S100 calcium binding protein A9 -0.00913399
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.00909874
VCL vinculin -0.00834193
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.00802102
GPHN gephyrin -0.00661778
ASPH aspartate beta-hydroxylase -0.00458142
INHBA inhibin, beta A -0.00391507
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.00359949
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0021261
SETD5 SET domain containing 5 -0.00206697
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.00617E-4