18β-Glycyrrhetinic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.131425
VIM vimentin 0.130897
RPS6 ribosomal protein S6 0.114173
TMSB10 thymosin beta 10 0.102806
COL11A1 collagen, type XI, alpha 1 0.0981062
RPS16 ribosomal protein S16 0.0970094
RPS12 ribosomal protein S12 0.0840878
MDK midkine (neurite growth-promoting factor 2) 0.080511
LRRC4C leucine rich repeat containing 4C 0.0735309
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0733992
CDH10 cadherin 10, type 2 (T2-cadherin) 0.067898
RPL23 ribosomal protein L23 0.0653059
RPS8 ribosomal protein S8 0.065121
PCDH9 protocadherin 9 0.0635808
RPL37 ribosomal protein L37 0.0602966
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0595272
RPL35A ribosomal protein L35a 0.0577107
RPL12 ribosomal protein L12 0.0571587
TPT1 tumor protein, translationally-controlled 1 0.0558254
B2M beta-2-microglobulin 0.0553538
DST dystonin 0.0547547
RPL9 ribosomal protein L9 0.0536615
RPS19 ribosomal protein S19 0.0532516
GARS1 glycyl-tRNA synthetase 1 0.0525416
ENO1 enolase 1, (alpha) 0.0504956
PGK1 phosphoglycerate kinase 1 0.0504808
RPL11 ribosomal protein L11 0.0476157
BPTF bromodomain PHD finger transcription factor 0.0456514
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0455067
RPLP0 ribosomal protein, large, P0 0.0451098
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0447713
SNX6 sorting nexin 6 0.0426209
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0416985
CALR calreticulin 0.041125
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0411248
FTL ferritin, light polypeptide 0.0410339
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0410028
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0407849
APOE apolipoprotein E 0.0403636
MT2A metallothionein 2A 0.0401288
RACK1 receptor for activated C kinase 1 0.0401005
LDHA lactate dehydrogenase A 0.0383774
RPL31 ribosomal protein L31 0.0383718
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0377568
RPL28 ribosomal protein L28 0.0377355
CDH19 cadherin 19, type 2 0.0376
NSUN6 NOP2/Sun domain family, member 6 0.0365841
NFE2L2 nuclear factor, erythroid 2-like 2 0.0365401
CNRIP1 cannabinoid receptor interacting protein 1 0.0363596
RPLP1 ribosomal protein, large, P1 0.0353809
RPL37A ribosomal protein L37a 0.0349472
NACA nascent polypeptide-associated complex alpha subunit 0.0348647
AKAP12 A kinase (PRKA) anchor protein 12 0.0348061
FST follistatin 0.034755
TTC3 tetratricopeptide repeat domain 3 0.0340737
RPS27 ribosomal protein S27 0.0335881
GNAS GNAS complex locus 0.0335716
DDIT3 DNA-damage-inducible transcript 3 0.0334445
ISG15 ISG15 ubiquitin-like modifier 0.0331614
FAM177A1 family with sequence similarity 177, member A1 0.0326185
RPS24 ribosomal protein S24 0.0325277
RPL30 ribosomal protein L30 0.0322601
IGF2 insulin-like growth factor 2 0.0320998
MACF1 microtubule-actin crosslinking factor 1 0.0320446
RPL7 ribosomal protein L7 0.0316443
SRRM2 serine/arginine repetitive matrix 2 0.0309141
RPS17 ribosomal protein S17 0.0307467
AKAP9 A kinase (PRKA) anchor protein 9 0.0304578
DDIT4 DNA-damage-inducible transcript 4 0.0304338
EIF5B eukaryotic translation initiation factor 5B 0.0302033
RPS3 ribosomal protein S3 0.030115
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0300493
EIF1 eukaryotic translation initiation factor 1 0.029568
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0294076
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0289459
RPL7A ribosomal protein L7a 0.0287145
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0284423
RPS14 ribosomal protein S14 0.0283798
ATF4 activating transcription factor 4 0.0276423
RPL18 ribosomal protein L18 0.0269417
NBEAL1 neurobeachin-like 1 0.0267241
WSB1 WD repeat and SOCS box containing 1 0.0262539
SOX5 SRY (sex determining region Y)-box 5 0.0262291
CSNK1A1 casein kinase 1, alpha 1 0.0256871
EZR ezrin 0.0253703
RPL5 ribosomal protein L5 0.0253033
RPL26 ribosomal protein L26 0.0252628
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0252048
ZFP36L1 ZFP36 ring finger protein-like 1 0.0251004
SAMD11 sterile alpha motif domain containing 11 0.0248932
SARS1 seryl-tRNA synthetase 1 0.0247722
SORBS2 sorbin and SH3 domain containing 2 0.0244143
KPNB1 karyopherin (importin) beta 1 0.02425
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0239351
RSF1 remodeling and spacing factor 1 0.0239312
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0239031
HSPB1 heat shock 27kDa protein 1 0.0237521
RPL19 ribosomal protein L19 0.0237353
DUSP6 dual specificity phosphatase 6 0.023712
RPS4X ribosomal protein S4, X-linked 0.0235358

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.103033
FNDC3B fibronectin type III domain containing 3B -0.0899568
ITGAV integrin, alpha V -0.0791437
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0614529
ADGRL2 adhesion G protein-coupled receptor L2 -0.0607596
NRG1 neuregulin 1 -0.0560699
TENM3 teneurin transmembrane protein 3 -0.0517146
EMP1 epithelial membrane protein 1 -0.0498474
TSC22D2 TSC22 domain family, member 2 -0.0483751
THBS1 thrombospondin 1 -0.0474525
STRN3 striatin, calmodulin binding protein 3 -0.0434183
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.043368
APP amyloid beta (A4) precursor protein -0.0431242
ADAM9 ADAM metallopeptidase domain 9 -0.0429338
ZNF292 zinc finger protein 292 -0.0425999
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0410542
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0408182
COL1A2 collagen, type I, alpha 2 -0.039496
ZFAND3 zinc finger, AN1-type domain 3 -0.0391247
TPX2 TPX2, microtubule-associated -0.0382111
HMGB2 high mobility group box 2 -0.0371865
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0368634
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0351701
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0346601
AHNAK AHNAK nucleoprotein -0.0342576
COL5A2 collagen, type V, alpha 2 -0.0337476
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0336132
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0333616
HDAC9 histone deacetylase 9 -0.0325843
NTM neurotrimin -0.0321714
TMSB4X thymosin beta 4, X-linked -0.032072
ANKRD33B ankyrin repeat domain 33B -0.0318951
MARCHF6 membrane associated ring-CH-type finger 6 -0.0318162
TEX11 testis expressed 11 -0.0317338
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0315807
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0308942
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0308107
RHEB Ras homolog enriched in brain -0.0306933
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0305073
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0298166
PUM1 pumilio RNA-binding family member 1 -0.0296095
RBM39 RNA binding motif protein 39 -0.029423
SAMD4A sterile alpha motif domain containing 4A -0.0289887
PICALM phosphatidylinositol binding clathrin assembly protein -0.0288636
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0283298
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0281561
SET SET nuclear proto-oncogene -0.0281175
DENND4C DENN/MADD domain containing 4C -0.0277559
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0276409
ACTN4 actinin, alpha 4 -0.0267174
RAB1A RAB1A, member RAS oncogene family -0.0263886
UTRN utrophin -0.0263775
TOP2A topoisomerase (DNA) II alpha 170kDa -0.026235
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0261679
RBM33 RNA binding motif protein 33 -0.026166
ADGRG6 adhesion G protein-coupled receptor G6 -0.0260726
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0260153
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0259851
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0257601
KMT2E lysine (K)-specific methyltransferase 2E -0.0255788
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0255123
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0254817
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0254697
PTK2 protein tyrosine kinase 2 -0.0252641
SPAG9 sperm associated antigen 9 -0.0252284
MED13L mediator complex subunit 13-like -0.0251201
ECT2 epithelial cell transforming 2 -0.024867
DIDO1 death inducer-obliterator 1 -0.0248397
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0246915
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0245361
CLSPN claspin -0.0245279
YAP1 Yes-associated protein 1 -0.0244839
KDM5B lysine (K)-specific demethylase 5B -0.0243913
WAC WW domain containing adaptor with coiled-coil -0.0242024
CANX calnexin -0.0239921
ZC3H15 zinc finger CCCH-type containing 15 -0.023879
ZMYM2 zinc finger, MYM-type 2 -0.0235621
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0232683
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0232097
NONO non-POU domain containing, octamer-binding -0.0231663
PUM2 pumilio RNA-binding family member 2 -0.0231323
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0229837
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0228629
SRPK2 SRSF protein kinase 2 -0.0228509
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.022792
CENPE centromere protein E, 312kDa -0.0227813
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0226714
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0226084
OGA O-GlcNAcase -0.0225451
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.022488
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0224721
ZNF207 zinc finger protein 207 -0.0222463
SHROOM3 shroom family member 3 -0.0220727
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0220657
CHD1 chromodomain helicase DNA binding protein 1 -0.0220602
UBC ubiquitin C -0.022051
MATR3 matrin 3 -0.0220466
ATAD2 ATPase family, AAA domain containing 2 -0.0220444
SFRP4 secreted frizzled-related protein 4 -0.0219408
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0219219