18β-Glycyrrhetinic acid_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.203999
MT2A metallothionein 2A 0.135562
PRSS23 protease, serine, 23 0.0836498
FN1 fibronectin 1 0.0803466
PSD3 pleckstrin and Sec7 domain containing 3 0.0796823
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0775101
CD44 CD44 molecule (Indian blood group) 0.073695
TRIO trio Rho guanine nucleotide exchange factor 0.0703045
NRXN3 neurexin 3 0.068537
VIM vimentin 0.0600557
VEGFA vascular endothelial growth factor A 0.0597663
IGF2 insulin-like growth factor 2 0.0597096
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.059527
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0573315
IGFBP7 insulin-like growth factor binding protein 7 0.0571264
COL6A3 collagen, type VI, alpha 3 0.0565685
B2M beta-2-microglobulin 0.0556306
CDH13 cadherin 13 0.0554783
TGFBI transforming growth factor, beta-induced, 68kDa 0.055163
LOX lysyl oxidase 0.053937
MAP1B microtubule-associated protein 1B 0.0521401
EGFR epidermal growth factor receptor 0.0520182
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0507974
EFNA5 ephrin-A5 0.050424
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0503837
HLA-A major histocompatibility complex, class I, A 0.0494945
DST dystonin 0.047142
RAD51B RAD51 paralog B 0.0460561
HMGA2 high mobility group AT-hook 2 0.0445856
NDRG1 N-myc downstream regulated 1 0.0443974
ZBTB20 zinc finger and BTB domain containing 20 0.0438051
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0437288
HDAC9 histone deacetylase 9 0.0436241
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0429368
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0428158
AKAP12 A kinase (PRKA) anchor protein 12 0.0411677
PRELID2 PRELI domain containing 2 0.0390687
MYOF myoferlin 0.0381803
GSE1 Gse1 coiled-coil protein 0.0378179
RPL26 ribosomal protein L26 0.0364542
KMT2C lysine (K)-specific methyltransferase 2C 0.0357123
VCL vinculin 0.0355773
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0343753
GARS1 glycyl-tRNA synthetase 1 0.0341016
RPL11 ribosomal protein L11 0.0339724
WWOX WW domain containing oxidoreductase 0.0339266
ANXA2 annexin A2 0.0337155
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0336309
THBS1 thrombospondin 1 0.0329706
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0324325
NKTR natural killer cell triggering receptor 0.0320288
LPP LIM domain containing preferred translocation partner in lipoma 0.0319261
RPS12 ribosomal protein S12 0.0313715
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0309265
FRMD4A FERM domain containing 4A 0.0305095
JPH2 junctophilin 2 0.0298068
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.029614
GLIS3 GLIS family zinc finger 3 0.029427
RPS19 ribosomal protein S19 0.0291406
TAGLN2 transgelin 2 0.0288279
CBX3 chromobox homolog 3 0.0287749
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0286811
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0286213
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0285314
BTG1 B-cell translocation gene 1, anti-proliferative 0.0281773
RNF145 ring finger protein 145 0.0280716
ANO6 anoctamin 6 0.0275918
UBXN4 UBX domain protein 4 0.0271994
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.026964
PDE4D phosphodiesterase 4D, cAMP-specific 0.0269021
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0268354
IGFBP5 insulin-like growth factor binding protein 5 0.0267604
CDK6 cyclin-dependent kinase 6 0.0267268
LOXL2 lysyl oxidase-like 2 0.0267012
TTC3 tetratricopeptide repeat domain 3 0.0265711
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0262466
ASPH aspartate beta-hydroxylase 0.0262088
SYNPO synaptopodin 0.0261379
MACF1 microtubule-actin crosslinking factor 1 0.0255843
GNAS GNAS complex locus 0.0250729
LGALS1 lectin, galactoside-binding, soluble, 1 0.0248332
MBD5 methyl-CpG binding domain protein 5 0.0247668
ZNF644 zinc finger protein 644 0.0245437
PRKN parkin RBR E3 ubiquitin protein ligase 0.0243769
ZMYND8 zinc finger, MYND-type containing 8 0.0243388
MBNL1 muscleblind-like splicing regulator 1 0.0237853
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0237572
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0236445
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0235177
PKM pyruvate kinase, muscle 0.02351
MYH9 myosin, heavy chain 9, non-muscle 0.0233533
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0232838
ZSWIM6 zinc finger, SWIM-type containing 6 0.0232597
BBS9 Bardet-Biedl syndrome 9 0.0230791
NECTIN3 nectin cell adhesion molecule 3 0.0226889
TPI1 triosephosphate isomerase 1 0.0226627
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0226553
PDLIM5 PDZ and LIM domain 5 0.0225718
KAZN kazrin, periplakin interacting protein 0.0224913
CA12 carbonic anhydrase XII 0.0224869

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179779
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113849
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110851
UBC ubiquitin C -0.0995925
SDC4 syndecan 4 -0.0758824
ANXA5 annexin A5 -0.0675206
SPAG9 sperm associated antigen 9 -0.0607374
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0598563
GRB10 growth factor receptor-bound protein 10 -0.0522839
HOOK2 hook microtubule-tethering protein 2 -0.0507269
RAB1A RAB1A, member RAS oncogene family -0.0483672
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0474893
PDIA3 protein disulfide isomerase family A, member 3 -0.0474563
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0473741
COL1A1 collagen, type I, alpha 1 -0.0467811
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0459347
FNDC3B fibronectin type III domain containing 3B -0.0436724
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0424936
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0423205
CCNI cyclin I -0.0415712
PDIA4 protein disulfide isomerase family A, member 4 -0.0413572
TPM4 tropomyosin 4 -0.0394258
PTMA prothymosin, alpha -0.0392798
SOD2 superoxide dismutase 2, mitochondrial -0.0389787
COL1A2 collagen, type I, alpha 2 -0.0388192
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0387141
JUN jun proto-oncogene -0.0376028
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.037318
LONP2 lon peptidase 2, peroxisomal -0.0347743
SEC24D SEC24 family member D -0.0342229
IARS1 isoleucyl-tRNA synthetase 1 -0.0342192
ZNF292 zinc finger protein 292 -0.0336381
H3-3B H3.3 histone B -0.0332606
GLG1 golgi glycoprotein 1 -0.0331734
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0328548
COPB1 coatomer protein complex, subunit beta 1 -0.0323112
CALU calumenin -0.0321624
TPM2 tropomyosin 2 (beta) -0.0316109
WTAP Wilms tumor 1 associated protein -0.0315052
WAC WW domain containing adaptor with coiled-coil -0.0309224
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.030721
ADM adrenomedullin -0.0306401
SAR1A secretion associated, Ras related GTPase 1A -0.0306226
SEC31A SEC31 homolog A (S. cerevisiae) -0.0305714
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0305112
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0304464
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0299281
VDAC1 voltage-dependent anion channel 1 -0.0293796
GOLGA4 golgin A4 -0.0293763
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0292227
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0292021
OGA O-GlcNAcase -0.0290135
RSAD2 radical S-adenosyl methionine domain containing 2 -0.028888
NAMPT nicotinamide phosphoribosyltransferase -0.0284288
S100A10 S100 calcium binding protein A10 -0.0279138
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0276744
TFG TRK-fused gene -0.0276067
FLNB filamin B, beta -0.0274745
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0273526
UBE2H ubiquitin-conjugating enzyme E2H -0.0272828
TXNIP thioredoxin interacting protein -0.0272449
TMEM41B transmembrane protein 41B -0.0268972
CDK7 cyclin-dependent kinase 7 -0.0268809
IL6ST interleukin 6 signal transducer -0.026742
PRRC1 proline-rich coiled-coil 1 -0.0266493
STK17A serine/threonine kinase 17a -0.026583
CANX calnexin -0.0265432
STC1 stanniocalcin 1 -0.0263287
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0260562
SKP1 S-phase kinase-associated protein 1 -0.0259386
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0256024
ANKRD11 ankyrin repeat domain 11 -0.0255917
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0255039
COL6A1 collagen, type VI, alpha 1 -0.0254524
AHNAK AHNAK nucleoprotein -0.0248697
IFRD1 interferon-related developmental regulator 1 -0.0247324
ZNF207 zinc finger protein 207 -0.0245432
MTPN myotrophin -0.0245222
ABI1 abl-interactor 1 -0.0243664
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0240827
FNBP4 formin binding protein 4 -0.0234921
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0234334
TBC1D23 TBC1 domain family, member 23 -0.0233233
RTN4 reticulon 4 -0.0233149
ERLEC1 endoplasmic reticulum lectin 1 -0.0232953
ARHGAP10 Rho GTPase activating protein 10 -0.023281
CRLS1 cardiolipin synthase 1 -0.0231979
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0228505
CUL4B cullin 4B -0.0226544
ACVR1 activin A receptor, type I -0.022607
STAU1 staufen double-stranded RNA binding protein 1 -0.0225363
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0224354
SRPK2 SRSF protein kinase 2 -0.0224344
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0221801
HMGB2 high mobility group box 2 -0.0220646
HBP1 HMG-box transcription factor 1 -0.0218876
RBM39 RNA binding motif protein 39 -0.0218511
PNPLA8 patatin-like phospholipase domain containing 8 -0.0217758
ITM2B integral membrane protein 2B -0.0217278
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0217253