18β-Glycyrrhetinic acid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.23381
FTL ferritin, light polypeptide 0.14933
NDRG1 N-myc downstream regulated 1 0.144815
AKAP12 A kinase (PRKA) anchor protein 12 0.128306
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.107023
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0959435
B2M beta-2-microglobulin 0.0934873
ASPH aspartate beta-hydroxylase 0.0908054
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0867989
HMGA2 high mobility group AT-hook 2 0.0835387
EFNA5 ephrin-A5 0.079044
FTH1 ferritin, heavy polypeptide 1 0.0768938
RPS6 ribosomal protein S6 0.0733326
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0719077
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0677205
RPL12 ribosomal protein L12 0.0631583
OSMR oncostatin M receptor 0.0626772
HIPK2 homeodomain interacting protein kinase 2 0.0616434
TMEM156 transmembrane protein 156 0.061495
GLIS3 GLIS family zinc finger 3 0.0609555
RPL23 ribosomal protein L23 0.0598262
RPS19 ribosomal protein S19 0.0563247
RPS12 ribosomal protein S12 0.0521992
RPS27 ribosomal protein S27 0.0504361
ELL2 elongation factor, RNA polymerase II, 2 0.0501783
MBNL1 muscleblind-like splicing regulator 1 0.0484291
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.048033
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0478769
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0474023
EXT1 exostosin glycosyltransferase 1 0.0468241
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0464861
RPLP1 ribosomal protein, large, P1 0.044945
RACK1 receptor for activated C kinase 1 0.0444109
RPL9 ribosomal protein L9 0.0424943
NPAS2 neuronal PAS domain protein 2 0.0419084
ENO2 enolase 2 (gamma, neuronal) 0.0410101
IFITM1 interferon induced transmembrane protein 1 0.040773
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0402683
PLIN2 perilipin 2 0.0402387
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.040173
WSB1 WD repeat and SOCS box containing 1 0.0401225
WWTR1 WW domain containing transcription regulator 1 0.0397174
PALLD palladin, cytoskeletal associated protein 0.0394917
CAPN2 calpain 2, (m/II) large subunit 0.0394875
BASP1 brain abundant, membrane attached signal protein 1 0.0393017
ERRFI1 ERBB receptor feedback inhibitor 1 0.0387659
AKAP9 A kinase (PRKA) anchor protein 9 0.0386105
ATXN1 ataxin 1 0.0381035
CD44 CD44 molecule (Indian blood group) 0.0378839
ANGPTL4 angiopoietin-like 4 0.0376625
RPL31 ribosomal protein L31 0.0374646
RPL37 ribosomal protein L37 0.0372211
SMAD3 SMAD family member 3 0.036844
LGALS1 lectin, galactoside-binding, soluble, 1 0.0367393
AREG amphiregulin 0.0362066
ALCAM activated leukocyte cell adhesion molecule 0.0361227
ARHGAP5 Rho GTPase activating protein 5 0.0345595
TPI1 triosephosphate isomerase 1 0.0344648
FOXP1 forkhead box P1 0.0344055
TMEM165 transmembrane protein 165 0.0343807
DUSP6 dual specificity phosphatase 6 0.0340872
IFITM3 interferon induced transmembrane protein 3 0.0339539
BZW1 basic leucine zipper and W2 domains 1 0.033917
PDGFC platelet derived growth factor C 0.0337973
EIF1 eukaryotic translation initiation factor 1 0.0336157
SEPTIN9 septin 9 0.0334373
RPL18 ribosomal protein L18 0.0333997
RPL37A ribosomal protein L37a 0.0326788
LTBP1 latent transforming growth factor beta binding protein 1 0.0323543
ETV1 ets variant 1 0.0320054
SVIL supervillin 0.0319943
RPL26 ribosomal protein L26 0.0318758
VEGFA vascular endothelial growth factor A 0.0311269
AHNAK2 AHNAK nucleoprotein 2 0.0310384
EGFR epidermal growth factor receptor 0.0304372
NAMPT nicotinamide phosphoribosyltransferase 0.0303511
RPL36 ribosomal protein L36 0.0301997
PELO pelota homolog (Drosophila) 0.0299942
LOXL2 lysyl oxidase-like 2 0.0296451
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0295626
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0292565
RPS26 ribosomal protein S26 0.0291717
LIMCH1 LIM and calponin homology domains 1 0.0287997
TPT1 tumor protein, translationally-controlled 1 0.0286849
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0285943
ADAM8 ADAM metallopeptidase domain 8 0.0285627
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0285482
LOX lysyl oxidase 0.0284559
ITGA1 integrin, alpha 1 0.0280652
AHR aryl hydrocarbon receptor 0.0278879
RPL35A ribosomal protein L35a 0.0277856
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.027777
RNF24 ring finger protein 24 0.0277355
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0270415
IRS2 insulin receptor substrate 2 0.0269226
RPL35 ribosomal protein L35 0.0269116
ENO1 enolase 1, (alpha) 0.0268941
TGFA transforming growth factor, alpha 0.0265862
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0265751
CEP350 centrosomal protein 350kDa 0.0264139

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.173132
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.136919
UBC ubiquitin C -0.112004
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104028
NRG1 neuregulin 1 -0.100034
PTMA prothymosin, alpha -0.0945108
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0858444
S100A6 S100 calcium binding protein A6 -0.0824302
CANX calnexin -0.0779163
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0773007
CENPF centromere protein F, 350/400kDa -0.0573751
MCL1 myeloid cell leukemia 1 -0.0548467
ACBD3 acyl-CoA binding domain containing 3 -0.0541246
SQSTM1 sequestosome 1 -0.0538176
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0535318
CALU calumenin -0.0533168
MYH9 myosin, heavy chain 9, non-muscle -0.0527308
SPAG9 sperm associated antigen 9 -0.0479813
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0478624
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0438879
ZFP36L1 ZFP36 ring finger protein-like 1 -0.042673
RAB1A RAB1A, member RAS oncogene family -0.0421044
POTEF POTE ankyrin domain family, member F -0.0417259
AEBP2 AE binding protein 2 -0.0410159
CALR calreticulin -0.0402995
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0401185
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0392518
VCL vinculin -0.0386148
RHEB Ras homolog enriched in brain -0.0383906
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.037595
SOX5 SRY (sex determining region Y)-box 5 -0.0373
BIRC6 baculoviral IAP repeat containing 6 -0.0370534
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0353007
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0346988
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0346261
PDIA3 protein disulfide isomerase family A, member 3 -0.0344882
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0343656
CCNL1 cyclin L1 -0.0343537
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0338372
TFG TRK-fused gene -0.0333139
IER3 immediate early response 3 -0.0332007
DIAPH3 diaphanous-related formin 3 -0.0328447
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0322288
RPS27A ribosomal protein S27a -0.0320938
TM9SF3 transmembrane 9 superfamily member 3 -0.0315754
SPDYA speedy/RINGO cell cycle regulator family member A -0.0310975
HLA-B major histocompatibility complex, class I, B -0.0304261
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0303879
MKI67 marker of proliferation Ki-67 -0.0303327
IRAK3 interleukin-1 receptor-associated kinase 3 -0.030179
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0301613
TPM4 tropomyosin 4 -0.0293863
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0291873
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0288681
TRA2A transformer 2 alpha homolog (Drosophila) -0.0280195
ANKRD11 ankyrin repeat domain 11 -0.0279693
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.02795
HDGF hepatoma-derived growth factor -0.0278332
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0276601
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0269106
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0268388
PCBP2 poly(rC) binding protein 2 -0.0268035
ZMYND8 zinc finger, MYND-type containing 8 -0.0266924
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0266107
RBM25 RNA binding motif protein 25 -0.026456
USP34 ubiquitin specific peptidase 34 -0.0260407
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0260174
VMP1 vacuole membrane protein 1 -0.0259816
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0257839
NUP58 nucleoporin 58 -0.0257742
EEF2 eukaryotic translation elongation factor 2 -0.025724
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0255894
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0255195
GLG1 golgi glycoprotein 1 -0.0253393
HILPDA hypoxia inducible lipid droplet-associated -0.0248998
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0248955
KRT81 keratin 81, type II -0.0245842
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.024519
CTSD cathepsin D -0.0244636
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0244116
FUS FUS RNA binding protein -0.0243611
DEK DEK proto-oncogene -0.0239013
KAT6B K(lysine) acetyltransferase 6B -0.0238634
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0237828
FKBP1A FK506 binding protein 1A, 12kDa -0.0237293
DNM1L dynamin 1-like -0.0236548
COG5 component of oligomeric golgi complex 5 -0.0236534
UBE2K ubiquitin-conjugating enzyme E2K -0.023514
MON2 MON2 homolog (S. cerevisiae) -0.0233723
KPNB1 karyopherin (importin) beta 1 -0.0231652
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0231328
TUBA1B tubulin, alpha 1b -0.0231275
HMGA1 high mobility group AT-hook 1 -0.022995
FOSL1 FOS-like antigen 1 -0.0229922
TPM3 tropomyosin 3 -0.0229673
ZFAND3 zinc finger, AN1-type domain 3 -0.0227189
WNK1 WNK lysine deficient protein kinase 1 -0.0224956
ADAM17 ADAM metallopeptidase domain 17 -0.0223428
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0222545
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0220724