18β-Glycyrrhetinic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 18β-Glycyrrhetinic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 18β-Glycyrrhetinic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.25852
TPT1 tumor protein, translationally-controlled 1 0.114249
VCL vinculin 0.104287
INTS6 integrator complex subunit 6 0.0992697
CCND1 cyclin D1 0.0821925
RPS19 ribosomal protein S19 0.0742503
RPL37A ribosomal protein L37a 0.0708725
RPS12 ribosomal protein S12 0.0704543
RPS3 ribosomal protein S3 0.0696329
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0670017
MT2A metallothionein 2A 0.0669624
RPL26 ribosomal protein L26 0.0653428
LOC102724023 ES1 protein homolog, mitochondrial 0.0639248
SDK1 sidekick cell adhesion molecule 1 0.0636563
TMSB10 thymosin beta 10 0.062779
RPL23 ribosomal protein L23 0.0606957
FTL ferritin, light polypeptide 0.0578702
RPL31 ribosomal protein L31 0.0548598
RPL9 ribosomal protein L9 0.05413
TUBB4B tubulin, beta 4B class IVb 0.0532781
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0524145
NAV2 neuron navigator 2 0.0521073
RPS17 ribosomal protein S17 0.0478615
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0464979
CBX3 chromobox homolog 3 0.0459305
RAD51B RAD51 paralog B 0.0453779
LIMS1 LIM and senescent cell antigen-like domains 1 0.0435683
ASPH aspartate beta-hydroxylase 0.0435353
RBP1 retinol binding protein 1, cellular 0.0430512
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0421498
LRMDA leucine rich melanocyte differentiation associated 0.0421405
ACTN1 actinin, alpha 1 0.0419657
RPL12 ribosomal protein L12 0.0414601
EZR ezrin 0.0410611
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0409695
SAMD4A sterile alpha motif domain containing 4A 0.0402821
MRPS6 mitochondrial ribosomal protein S6 0.0395539
EXOC4 exocyst complex component 4 0.0375709
LAMA4 laminin, alpha 4 0.0372065
RPLP2 ribosomal protein, large, P2 0.0369859
CD44 CD44 molecule (Indian blood group) 0.0364523
PDLIM5 PDZ and LIM domain 5 0.0357749
EGR1 early growth response 1 0.0355544
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.035254
WWOX WW domain containing oxidoreductase 0.0348946
RPL18 ribosomal protein L18 0.0342541
BACE2 beta-site APP-cleaving enzyme 2 0.0340688
BCL2L1 BCL2-like 1 0.0337136
ZSWIM6 zinc finger, SWIM-type containing 6 0.0329983
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0325639
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0321879
UBAP2 ubiquitin associated protein 2 0.0321812
RCOR1 REST corepressor 1 0.0321498
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0319161
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0319088
RPS21 ribosomal protein S21 0.0317039
NTSR1 neurotensin receptor 1 (high affinity) 0.0313547
RPS8 ribosomal protein S8 0.0313272
POTEF POTE ankyrin domain family, member F 0.0311091
PDE4D phosphodiesterase 4D, cAMP-specific 0.0309215
FLNB filamin B, beta 0.0304796
ZBTB38 zinc finger and BTB domain containing 38 0.0303363
GLI3 GLI family zinc finger 3 0.0302934
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0298761
NCEH1 neutral cholesterol ester hydrolase 1 0.029591
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0293622
RPL21 ribosomal protein L21 0.0290322
VIM vimentin 0.0289768
RPL27 ribosomal protein L27 0.0289117
RPS14 ribosomal protein S14 0.0285998
EGFR epidermal growth factor receptor 0.0284747
NOP56 NOP56 ribonucleoprotein 0.0281933
RPL11 ribosomal protein L11 0.0278896
TUBA1B tubulin, alpha 1b 0.0278674
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0273386
PA2G4 proliferation-associated 2G4, 38kDa 0.0268315
FHIT fragile histidine triad 0.0267699
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0264078
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0260906
SYNJ2 synaptojanin 2 0.0258268
APLP2 amyloid beta (A4) precursor-like protein 2 0.0251013
NPAS2 neuronal PAS domain protein 2 0.024731
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0244657
SMAD3 SMAD family member 3 0.024134
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0237625
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0237177
COBL cordon-bleu WH2 repeat protein 0.0233519
GPHN gephyrin 0.023192
SQSTM1 sequestosome 1 0.0230067
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0229144
LDHA lactate dehydrogenase A 0.0228135
EIF5 eukaryotic translation initiation factor 5 0.0228024
IRS2 insulin receptor substrate 2 0.0226333
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0224607
SFPQ splicing factor proline/glutamine-rich 0.0223735
B2M beta-2-microglobulin 0.0223186
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0223155
PMEPA1 prostate transmembrane protein, androgen induced 1 0.022174
ANO1 anoctamin 1, calcium activated chloride channel 0.0221706
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0221493

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138766
NKD1 naked cuticle homolog 1 (Drosophila) -0.107948
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0889201
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0868913
ESYT2 extended synaptotagmin-like protein 2 -0.0830984
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0678366
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0645817
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0642717
CANX calnexin -0.0603515
SBF2 SET binding factor 2 -0.0583987
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.057568
KDM3A lysine (K)-specific demethylase 3A -0.0571976
GLG1 golgi glycoprotein 1 -0.0571398
H1-0 H1.0 linker histone -0.0560621
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0546188
OGA O-GlcNAcase -0.0529432
PGK1 phosphoglycerate kinase 1 -0.0522239
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0521301
RAD21 RAD21 homolog (S. pombe) -0.0518183
GOLGA4 golgin A4 -0.0486482
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0470189
ANLN anillin, actin binding protein -0.0467373
KMT2C lysine (K)-specific methyltransferase 2C -0.0466533
OXR1 oxidation resistance 1 -0.0461604
RBM39 RNA binding motif protein 39 -0.0457167
WDFY2 WD repeat and FYVE domain containing 2 -0.0455295
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0448465
BIRC6 baculoviral IAP repeat containing 6 -0.0447883
BRWD3 bromodomain and WD repeat domain containing 3 -0.0447436
AKAP12 A kinase (PRKA) anchor protein 12 -0.0443841
ABHD2 abhydrolase domain containing 2 -0.0442001
MORF4L2 mortality factor 4 like 2 -0.0438642
RICTOR RPTOR independent companion of MTOR, complex 2 -0.042839
PDE8A phosphodiesterase 8A -0.0420001
AHNAK AHNAK nucleoprotein -0.041687
RUNX1 runt-related transcription factor 1 -0.0397954
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0394963
JMJD1C jumonji domain containing 1C -0.0391641
KIZ kizuna centrosomal protein -0.0388238
MATR3 matrin 3 -0.0387805
USP3 ubiquitin specific peptidase 3 -0.0386816
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.038528
GARS1 glycyl-tRNA synthetase 1 -0.0380222
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0373831
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0371365
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0369452
PROX1 prospero homeobox 1 -0.0368876
EEF2 eukaryotic translation elongation factor 2 -0.0367421
TMSB4X thymosin beta 4, X-linked -0.0366323
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0358823
XPO1 exportin 1 -0.0357338
AVL9 AVL9 homolog (S. cerevisiase) -0.0356729
HELZ helicase with zinc finger -0.0354787
CD46 CD46 molecule, complement regulatory protein -0.0353334
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0352448
ZFR zinc finger RNA binding protein -0.0350748
RAB6A RAB6A, member RAS oncogene family -0.0349104
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0348131
USP34 ubiquitin specific peptidase 34 -0.0347872
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0345006
CEP95 centrosomal protein 95kDa -0.0344951
PIBF1 progesterone immunomodulatory binding factor 1 -0.0340828
TMEM41B transmembrane protein 41B -0.0338544
RAB1A RAB1A, member RAS oncogene family -0.0338425
PDGFA platelet-derived growth factor alpha polypeptide -0.0336817
KRT8 keratin 8, type II -0.0336463
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0331069
ETNK1 ethanolamine kinase 1 -0.0327251
AOPEP aminopeptidase O (putative) -0.0326743
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0325613
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0324729
CFDP1 craniofacial development protein 1 -0.0323325
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0319324
ZMYND8 zinc finger, MYND-type containing 8 -0.0317758
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0315772
NIPSNAP2 nipsnap homolog 2 -0.0315461
ZNF292 zinc finger protein 292 -0.031292
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0310442
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0310194
NSD3 nuclear receptor binding SET domain protein 3 -0.0307118
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0304414
NF1 neurofibromin 1 -0.0304021
DDIT4 DNA-damage-inducible transcript 4 -0.0303794
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0302712
WDR45B WD repeat domain 45B -0.0302699
SETD5 SET domain containing 5 -0.0299453
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0298716
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0298714
MAML2 mastermind-like 2 (Drosophila) -0.0298576
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.029843
CEMIP2 cell migration inducing hyaluronidase 2 -0.0297809
RLF rearranged L-myc fusion -0.0296413
BHLHE40 basic helix-loop-helix family, member e40 -0.0295716
EPB41 erythrocyte membrane protein band 4.1 -0.0293787
SEPTIN2 septin 2 -0.0293671
PDIA3 protein disulfide isomerase family A, member 3 -0.0292685
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0292082
COPB1 coatomer protein complex, subunit beta 1 -0.0284629
STK4 serine/threonine kinase 4 -0.0282427
MAP4 microtubule-associated protein 4 -0.0281611