2,6-dimethylpiperidine-4363 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the 2,6-dimethylpiperidine-4363 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AMN amnion associated transmembrane protein
ATXN7L1 ataxin 7-like 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BDKRB2 bradykinin receptor B2
BIN1 bridging integrator 1
BMP8A bone morphogenetic protein 8a
C22ORF46 chromosome 22 open reading frame 46
CD200 CD200 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CELF3 CUGBP, Elav-like family member 3
CLEC7A C-type lectin domain family 7, member A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
EPHB2 EPH receptor B2
FLT3 fms-related tyrosine kinase 3
FRMD8 FERM domain containing 8
FST follistatin
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
GPATCH4 G patch domain containing 4
GPR37L1 G protein-coupled receptor 37 like 1
H2AFX H2A histone family, member X
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA1 homeobox A1
HOXA6 homeobox A6
HSF4 heat shock transcription factor 4
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IMPG2 interphotoreceptor matrix proteoglycan 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNK10 potassium channel, two pore domain subfamily K, member 10
KERA keratocan
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LDHB lactate dehydrogenase B
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOXL2 lysyl oxidase-like 2
LOXL3 lysyl oxidase-like 3
MC5R melanocortin 5 receptor
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MMP19 matrix metallopeptidase 19
MNMIP1 manchette microtubule inner protein 1
MOBP myelin-associated oligodendrocyte basic protein
MYH15 myosin, heavy chain 15
MYT1 myelin transcription factor 1
N4BP1 NEDD4 binding protein 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OSBPL7 oxysterol binding protein-like 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4DIP phosphodiesterase 4D interacting protein
PGLYRP4 peptidoglycan recognition protein 4
PKD2L2 polycystic kidney disease 2-like 2
PLCB2 phospholipase C, beta 2
PLEK pleckstrin
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKCB protein kinase C, beta
PRLH prolactin releasing hormone
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RFC1 replication factor C (activator 1) 1, 145kDa
SCAPER S-phase cyclin A-associated protein in the ER
SERHL2 serine hydrolase-like 2
SFTPC surfactant protein C
SLC25A30 solute carrier family 25, member 30
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SULT4A1 sulfotransferase family 4A, member 1
SV2A synaptic vesicle glycoprotein 2A
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAGLN3 transgelin 3
TAPT1 transmembrane anterior posterior transformation 1
TDRD12 tudor domain containing 12
THRB thyroid hormone receptor, beta
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRBC1 T cell receptor beta constant 1
UTRN utrophin
WNT8B wingless-type MMTV integration site family, member 8B
WSCD1 WSC domain containing 1
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZNF264 zinc finger protein 264
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
ANXA2P3 annexin A2 pseudogene 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMC4 armadillo repeat containing 4
BHLHE41 basic helix-loop-helix family, member e41
C1ORF109 chromosome 1 open reading frame 109
CALML5 calmodulin-like 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN5 calpain 5
CCDC9 coiled-coil domain containing 9
CDK3 cyclin-dependent kinase 3
CES3 carboxylesterase 3
CIDEB cell death-inducing DFFA-like effector b
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CUZD1 CUB and zona pellucida-like domains 1
CXORF56 chromosome X open reading frame 56
DBR1 debranching RNA lariats 1
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNM1 dynamin 1
ERCC2 excision repair cross-complementation group 2
ETV6 ets variant 6
EVPL envoplakin
EXO5 exonuclease 5
FBXO2 F-box protein 2
FKRP fukutin related protein
FLT4 fms-related tyrosine kinase 4
GMEB1 glucocorticoid modulatory element binding protein 1
GPR143 G protein-coupled receptor 143
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAUS6 HAUS augmin-like complex, subunit 6
HCAR3 hydroxycarboxylic acid receptor 3
HDAC7 histone deacetylase 7
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AK histone cluster 1, H2ak
HIST1H2BC histone cluster 1, H2bc
HSPA1L heat shock 70kDa protein 1-like
ITPKB inositol-trisphosphate 3-kinase B
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0319L KIAA0319-like
KLF11 Kruppel-like factor 11
KLHL25 kelch-like family member 25
LIN7A lin-7 homolog A (C. elegans)
LINS lines homolog (Drosophila)
LOC157562 uncharacterized LOC157562
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN3 mucolipin 3
NCALD neurocalcin delta
NPFFR1 neuropeptide FF receptor 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUD3 OTU deubiquitinase 3
OVGP1 oviductal glycoprotein 1, 120kDa
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB3 protocadherin beta 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNA3 plexin A3
PRR4 proline rich 4 (lacrimal)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
QPCTL glutaminyl-peptide cyclotransferase-like
RAB30 RAB30, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SGMS1 sphingomyelin synthase 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STON1 stonin 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM120B transmembrane protein 120B
TMEM209 transmembrane protein 209
TMPRSS2 transmembrane protease, serine 2
TRAIP TRAF interacting protein
TRDMT1 tRNA aspartic acid methyltransferase 1
TTF2 transcription termination factor, RNA polymerase II
USP19 ubiquitin specific peptidase 19
VASH1 vasohibin 1
WDR19 WD repeat domain 19
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX4 zinc finger homeobox 4
ZNF16 zinc finger protein 16
ZNF212 zinc finger protein 212
ZNF286A zinc finger protein 286A
ZNF551 zinc finger protein 551
ZNF573 zinc finger protein 573
ZNRD1-AS1 ZNRD1 antisense RNA 1