3-acetylcoumarin-5259 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the 3-acetylcoumarin-5259 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADCY10 adenylate cyclase 10 (soluble)
ADORA1 adenosine A1 receptor
ALOX12 arachidonate 12-lipoxygenase
AMPD3 adenosine monophosphate deaminase 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATN1 atrophin 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BMP3 bone morphogenetic protein 3
C19ORF66 chromosome 19 open reading frame 66
C1ORF61 chromosome 1 open reading frame 61
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL27 chemokine (C-C motif) ligand 27
CD83 CD83 molecule
CDO1 cysteine dioxygenase type 1
CFAP70 cilia and flagella associated protein 70
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLEC2D C-type lectin domain family 2, member D
CTNS cystinosin, lysosomal cystine transporter
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DGCR2 DiGeorge syndrome critical region gene 2
DSC3 desmocollin 3
DVL2 dishevelled segment polarity protein 2
FAM214B family with sequence similarity 214, member B
FCGBP Fc fragment of IgG binding protein
FLJ11292
FLOT1 flotillin 1
FOXG1 forkhead box G1
FST follistatin
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GLP1R glucagon-like peptide 1 receptor
GRIK5 glutamate receptor, ionotropic, kainate 5
GZMK granzyme K (granzyme 3; tryptase II)
HCG4B HLA complex group 4B (non-protein coding)
HGD homogentisate 1,2-dioxygenase
HIST1H3I histone cluster 1, H3i
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBC inhibin, beta C
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KDM5C lysine (K)-specific demethylase 5C
KLK8 kallikrein-related peptidase 8
KRT37 keratin 37, type I
LTC4S leukotriene C4 synthase
LY86 lymphocyte antigen 86
MPL MPL proto-oncogene, thrombopoietin receptor
MYLK myosin light chain kinase
NDRG2 NDRG family member 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PER1 period circadian clock 1
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PRKCB protein kinase C, beta
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIF1 replication timing regulatory factor 1
RORC RAR-related orphan receptor C
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A9 solute carrier family 39, member 9
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SULT4A1 sulfotransferase family 4A, member 1
SVIL supervillin
SYT5 synaptotagmin V
T T, brachyury homolog (mouse)
TBC1D2 TBC1 domain family, member 2
TBC1D22A TBC1 domain family, member 22A
TBX19 T-box 19
TBX5 T-box 5
TMPRSS15 transmembrane protease, serine 15
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VN1R1 vomeronasal 1 receptor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF362 zinc finger protein 362
ZNF37BP zinc finger protein 37B, pseudogene
ZNF76 zinc finger protein 76
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBC3 BCL2 binding component 3
C14ORF79 chromosome 14 open reading frame 79
C17ORF70 chromosome 17 open reading frame 70
C2ORF27A chromosome 2 open reading frame 27A
CAPN15 calpain 15
CCDC132 coiled-coil domain containing 132
CEP295 centrosomal protein 295kDa
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COL9A2 collagen, type IX, alpha 2
CRELD1 cysteine-rich with EGF-like domains 1
CTNNBIP1 catenin, beta interacting protein 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DGKE diacylglycerol kinase, epsilon 64kDa
DNAH17 dynein, axonemal, heavy chain 17
DNAL4 dynein, axonemal, light chain 4
DNM3 dynamin 3
EDAR ectodysplasin A receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV6 ets variant 6
FBXW12 F-box and WD repeat domain containing 12
FILIP1L filamin A interacting protein 1-like
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR1 G protein-coupled receptor 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HIST1H1D histone cluster 1, H1d
HIST1H4E histone cluster 1, H4e
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DMA major histocompatibility complex, class II, DM alpha
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
KIAA1107 KIAA1107
LAMB3 laminin, beta 3
LIME1 Lck interacting transmembrane adaptor 1
LINS lines homolog (Drosophila)
LRRC37A3 leucine rich repeat containing 37, member A3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRPL41 mitochondrial ribosomal protein L41
MRPS18C mitochondrial ribosomal protein S18C
MTA2 metastasis associated 1 family, member 2
MTCP1 mature T-cell proliferation 1
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
NFE2L3 nuclear factor, erythroid 2-like 3
NKX3-2 NK3 homeobox 2
NLRX1 NLR family member X1
NPFFR1 neuropeptide FF receptor 1
OVOL1 ovo-like zinc finger 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PGPEP1 pyroglutamyl-peptidase I
PITX2 paired-like homeodomain 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRKCE protein kinase C, epsilon
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFPL3 ret finger protein-like 3
RGS19 regulator of G-protein signaling 19
RHBDD3 rhomboid domain containing 3
RNF43 ring finger protein 43
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SCHIP1 schwannomin interacting protein 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC22A14 solute carrier family 22, member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SOAT2 sterol O-acyltransferase 2
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TBC1D19 TBC1 domain family, member 19
TEP1 telomerase-associated protein 1
TESK1 testis-specific kinase 1
TLR5 toll-like receptor 5
TM7SF3 transmembrane 7 superfamily member 3
TMEM254 transmembrane protein 254
TRIM36 tripartite motif containing 36
TYK2 tyrosine kinase 2
UBQLN4 ubiquilin 4
UBXN6 UBX domain protein 6
USB1 U6 snRNA biogenesis 1
WDR25 WD repeat domain 25
ZIC3 Zic family member 3
ZNF329 zinc finger protein 329
ZNF480 zinc finger protein 480
ZNF652 zinc finger protein 652
ZNF750 zinc finger protein 750
ZNF787 zinc finger protein 787