3-hydroxy-DL-kynurenine-4681 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the 3-hydroxy-DL-kynurenine-4681 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADGRB2 adhesion G protein-coupled receptor B2
AIF1 allograft inflammatory factor 1
AK5 adenylate kinase 5
APOC4 apolipoprotein C-IV
ATXN7L1 ataxin 7-like 1
C9ORF9 chromosome 9 open reading frame 9
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CACYBP calcyclin binding protein
CADM4 cell adhesion molecule 4
CARTPT CART prepropeptide
CCDC170 coiled-coil domain containing 170
CD80 CD80 molecule
CLEC11A C-type lectin domain family 11, member A
CNTN5 contactin 5
CSHL1 chorionic somatomammotropin hormone-like 1
CSPG4 chondroitin sulfate proteoglycan 4
CXCR6 chemokine (C-X-C motif) receptor 6
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DPF1 D4, zinc and double PHD fingers family 1
DTX2 deltex 2, E3 ubiquitin ligase
E2F4 E2F transcription factor 4, p107/p130-binding
EML2 echinoderm microtubule associated protein like 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EXO5 exonuclease 5
FAM131B family with sequence similarity 131, member B
FBRS fibrosin
FYB FYN binding protein
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GIMAP6 GTPase, IMAP family member 6
GOSR2 golgi SNAP receptor complex member 2
GRM4 glutamate receptor, metabotropic 4
HGD homogentisate 1,2-dioxygenase
HHAT hedgehog acyltransferase
HIC2 hypermethylated in cancer 2
HLF hepatic leukemia factor
HPS1 Hermansky-Pudlak syndrome 1
IL18R1 interleukin 18 receptor 1
ING2 inhibitor of growth family, member 2
IRF5 interferon regulatory factor 5
KIF25-AS1 KIF25 antisense RNA 1
LAMC2 laminin, gamma 2
LECT2 leukocyte cell-derived chemotaxin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MRPL20 mitochondrial ribosomal protein L20
MST1 macrophage stimulating 1
MVD mevalonate (diphospho) decarboxylase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD1 nucleotide-binding oligomerization domain containing 1
NOVA2 neuro-oncological ventral antigen 2
NPC1 Niemann-Pick disease, type C1
NUDC nudC nuclear distribution protein
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PASK PAS domain containing serine/threonine kinase
PCDHB3 protocadherin beta 3
PCDHGB6 protocadherin gamma subfamily B, 6
PCNX pecanex homolog (Drosophila)
PF4 platelet factor 4
PLBD1 phospholipase B domain containing 1
PLXNB3 plexin B3
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RECQL5 RecQ protein-like 5
RNF122 ring finger protein 122
RNF6 ring finger protein (C3H2C3 type) 6
RPS14 ribosomal protein S14
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHOX2 short stature homeobox 2
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
STRA6 stimulated by retinoic acid 6
SUGP1 SURP and G patch domain containing 1
TADA3 transcriptional adaptor 3
TAOK2 TAO kinase 2
TCP11L1 t-complex 11, testis-specific-like 1
TEX14 testis expressed 14
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM121 transmembrane protein 121
TP53I11 tumor protein p53 inducible protein 11
TRIM29 tripartite motif containing 29
TSPAN9 tetraspanin 9
UBXN1 UBX domain protein 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VASH1 vasohibin 1
WDR62 WD repeat domain 62
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF214 zinc finger protein 214
ZNF268 zinc finger protein 268

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AFF4 AF4/FMR2 family, member 4
AGMAT agmatine ureohydrolase (agmatinase)
AGO4 argonaute RISC catalytic component 4
ALB albumin
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C11ORF63 chromosome 11 open reading frame 63
CAMKMT calmodulin-lysine N-methyltransferase
CCDC132 coiled-coil domain containing 132
CDK6 cyclin-dependent kinase 6
CDKL3 cyclin-dependent kinase-like 3
CHRDL1 chordin-like 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCN5 chloride channel, voltage-sensitive 5
CNN1 calponin 1, basic, smooth muscle
CORO1A coronin, actin binding protein, 1A
CORO2B coronin, actin binding protein, 2B
CPPED1 calcineurin-like phosphoesterase domain containing 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUOX2 dual oxidase 2
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM184A family with sequence similarity 184, member A
FAM212B family with sequence similarity 212, member B
FBXO31 F-box protein 31
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
FRMPD1 FERM and PDZ domain containing 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPC3 glypican 3
GPR1 G protein-coupled receptor 1
HIST1H4E histone cluster 1, H4e
HOXA1 homeobox A1
HOXA6 homeobox A6
HOXC5 homeobox C5
HRH2 histamine receptor H2
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IDI2-AS1 IDI2 antisense RNA 1
IFT140 intraflagellar transport 140
IGFBP1 insulin-like growth factor binding protein 1
KIAA1462 KIAA1462
KLF3 Kruppel-like factor 3 (basic)
KLHL25 kelch-like family member 25
KRT33A keratin 33A, type I
LMTK1 lemur tail kinase 1
LOC257152 uncharacterized LOC257152
LYPD3 LY6/PLAUR domain containing 3
MCC mutated in colorectal cancers
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MYO1F myosin IF
MYOZ3 myozenin 3
NAG18 NAG18 mRNA
NDP Norrie disease (pseudoglioma)
NEUROD1 neuronal differentiation 1
NME5 NME/NM23 family member 5
NNAT neuronatin
NPPB natriuretic peptide B
NTF3 neurotrophin 3
OLFM4 olfactomedin 4
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSBP2 oxysterol binding protein 2
PDE11A phosphodiesterase 11A
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKG2 protein kinase, cGMP-dependent, type II
PRM2 protamine 2
PRO2964 uncharacterized protein PRO2964
PRSS22 protease, serine, 22
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFTPA2 surfactant protein A2
SIRT2 sirtuin 2
SIX3 SIX homeobox 3
SPINK1 serine peptidase inhibitor, Kazal type 1
TCEAL2 transcription elongation factor A (SII)-like 2
TENM1 teneurin transmembrane protein 1
TMEM212 transmembrane protein 212
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF549 zinc finger protein 549
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768