3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate. (Gene Ontology, GO_0017086)
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Genes

24 proteins co-occuring with the 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BCKDK branched chain ketoacid dehydrogenase kinase 3.14123
DBT dihydrolipoamide branched chain transacylase E2 1.96356
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 1.65753
DLD dihydrolipoamide dehydrogenase 1.58391
HIBADH 3-hydroxyisobutyrate dehydrogenase 1.41923
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 1.28676
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1.19571
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 1.0569
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.817616
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.760887
SPAG11A sperm associated antigen 11A 0.74322
SPAG11B sperm associated antigen 11B 0.713238
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.545648
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.523885
TERF2 telomeric repeat binding factor 2 0.520615
PDHX pyruvate dehydrogenase complex, component X 0.4608
TKT transketolase 0.362804
GGT2 gamma-glutamyltransferase 2 0.279612
PC pyruvate carboxylase 0.263485
CS citrate synthase 0.260202
PPARA peroxisome proliferator-activated receptor alpha 0.181524
GPX5 glutathione peroxidase 5 0.168349
GPX4 glutathione peroxidase 4 0.16477
GPX1 glutathione peroxidase 1 0.159074
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