3-nitropropionic acid-6367 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the 3-nitropropionic acid-6367 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
ADAM28 ADAM metallopeptidase domain 28
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AK1 adenylate kinase 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMPD1 adenosine monophosphate deaminase 1
ARL4C ADP-ribosylation factor-like 4C
ARRB1 arrestin, beta 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BGN biglycan
C14ORF1 chromosome 14 open reading frame 1
C1ORF61 chromosome 1 open reading frame 61
CASQ2 calsequestrin 2 (cardiac muscle)
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD52 CD52 molecule
CDC5L cell division cycle 5-like
CES1 carboxylesterase 1
COL17A1 collagen, type XVII, alpha 1
COL9A3 collagen, type IX, alpha 3
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CSF1 colony stimulating factor 1 (macrophage)
CXCR6 chemokine (C-X-C motif) receptor 6
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DNAI2 dynein, axonemal, intermediate chain 2
DNASE1L2 deoxyribonuclease I-like 2
DOC2B double C2-like domains, beta
DYM dymeclin
ETV1 ets variant 1
FAM76A family with sequence similarity 76, member A
FHL1 four and a half LIM domains 1
FLOT1 flotillin 1
FRMD1 FERM domain containing 1
GPX2 glutathione peroxidase 2
HRH3 histamine receptor H3
IFNW1 interferon, omega 1
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL11 interleukin 11
IL23A interleukin 23, alpha subunit p19
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KALRN kalirin, RhoGEF kinase
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0125 KIAA0125
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAT2 linker for activation of T cells family, member 2
LENEP lens epithelial protein
LRP2 low density lipoprotein receptor-related protein 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MCAM melanoma cell adhesion molecule
MED20 mediator complex subunit 20
MFAP3 microfibrillar-associated protein 3
MMP8 matrix metallopeptidase 8
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC6 mucin 6, oligomeric mucus/gel-forming
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEUROD4 neuronal differentiation 4
NPAS3 neuronal PAS domain protein 3
NTF3 neurotrophin 3
NXPH3 neurexophilin 3
OLFM1 olfactomedin 1
OLIG2 oligodendrocyte lineage transcription factor 2
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OSBP2 oxysterol binding protein 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLAU plasminogen activator, urokinase
POM121L2 POM121 transmembrane nucleoporin-like 2
PQLC3 PQ loop repeat containing 3
PRB1 proline-rich protein BstNI subfamily 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
S100A12 S100 calcium binding protein A12
S100A13 S100 calcium binding protein A13
SHOX2 short stature homeobox 2
SIX3 SIX homeobox 3
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNPH syntaphilin
SOAT2 sterol O-acyltransferase 2
SOS2 son of sevenless homolog 2 (Drosophila)
STMN1 stathmin 1
STOML1 stomatin (EPB72)-like 1
SUGP1 SURP and G patch domain containing 1
TAOK1 TAO kinase 1
TCF20 transcription factor 20 (AR1)
TENM1 teneurin transmembrane protein 1
TMEM259 transmembrane protein 259
TNNT2 troponin T type 2 (cardiac)
TP63 tumor protein p63
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TUBBP5 tubulin, beta pseudogene 5
VCL vinculin
VGLL3 vestigial-like family member 3
WNT2B wingless-type MMTV integration site family, member 2B
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
BEST2 bestrophin 2
BTNL2 butyrophilin-like 2
C1QTNF1 C1q and tumor necrosis factor related protein 1
C7ORF43 chromosome 7 open reading frame 43
CCL16 chemokine (C-C motif) ligand 16
CCRL2 chemokine (C-C motif) receptor-like 2
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC4E C-type lectin domain family 4, member E
CLIP2 CAP-GLY domain containing linker protein 2
CLSTN2 calsyntenin 2
CNTNAP1 contactin associated protein 1
COL9A1 collagen, type IX, alpha 1
CPLX2 complexin 2
CRISP2 cysteine-rich secretory protein 2
CT55 cancer/testis antigen 55
CXXC4 CXXC finger protein 4
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEPDC5 DEP domain containing 5
EPHB6 EPH receptor B6
ETV4 ets variant 4
EXTL1 exostosin-like glycosyltransferase 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
FGL1 fibrinogen-like 1
FLJ21369 uncharacterized protein FLJ21369
GMPR guanosine monophosphate reductase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GPR3 G protein-coupled receptor 3
GTPBP10 GTP-binding protein 10 (putative)
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H2BB histone cluster 1, H2bb
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSF4 heat shock transcription factor 4
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
HYPM huntingtin interacting protein M
IBSP integrin-binding sialoprotein
ICOS inducible T-cell co-stimulator
IDI2-AS1 IDI2 antisense RNA 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF13 Kruppel-like factor 13
KLK12 kallikrein-related peptidase 12
LIM2 lens intrinsic membrane protein 2, 19kDa
LIME1 Lck interacting transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LOC284244 uncharacterized LOC284244
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LSP1 lymphocyte-specific protein 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MALL mal, T-cell differentiation protein-like
MBNL3 muscleblind-like splicing regulator 3
MEGF8 multiple EGF-like-domains 8
MMP10 matrix metallopeptidase 10
MUC2 mucin 2, oligomeric mucus/gel-forming
MXRA8 matrix-remodelling associated 8
MYLK myosin light chain kinase
NLGN1 neuroligin 1
NNAT neuronatin
NPPA natriuretic peptide A
NPR3 natriuretic peptide receptor 3
NTN3 netrin 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX1 paired box 1
PCDHGA8 protocadherin gamma subfamily A, 8
PEAK1 pseudopodium-enriched atypical kinase 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLG plasminogen
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRN protein tyrosine phosphatase, receptor type, N
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPS2P45 ribosomal protein S2 pseudogene 45
RWDD3 RWD domain containing 3
SDS serine dehydratase
SIX1 SIX homeobox 1
SLC16A4 solute carrier family 16, member 4
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN5 spectrin, beta, non-erythrocytic 5
STMN4 stathmin-like 4
TERT telomerase reverse transcriptase
TM4SF5 transmembrane 4 L six family member 5
TMEM8B transmembrane protein 8B
TMPRSS4 transmembrane protease, serine 4
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM58 tripartite motif containing 58
WWC2 WW and C2 domain containing 2
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF134 zinc finger protein 134
ZNF506 zinc finger protein 506