3-nitropropionic acid-6372 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the 3-nitropropionic acid-6372 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACVR1B activin A receptor, type IB
AIM1L absent in melanoma 1-like
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
AVPR1A arginine vasopressin receptor 1A
BAIAP3 BAI1-associated protein 3
BCAS1 breast carcinoma amplified sequence 1
C11ORF16 chromosome 11 open reading frame 16
C14ORF1 chromosome 14 open reading frame 1
CADM4 cell adhesion molecule 4
CCDC121 coiled-coil domain containing 121
CD22 CD22 molecule
CD47 CD47 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CISH cytokine inducible SH2-containing protein
CLCA1 chloride channel accessory 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN9 claudin 9
CLUAP1 clusterin associated protein 1
CREBZF CREB/ATF bZIP transcription factor
DCTN1 dynactin 1
DHODH dihydroorotate dehydrogenase (quinone)
DTNB dystrobrevin, beta
DUSP26 dual specificity phosphatase 26 (putative)
ELL elongation factor RNA polymerase II
EPS8L1 EPS8-like 1
FAAH fatty acid amide hydrolase
FAM49B family with sequence similarity 49, member B
FBXO2 F-box protein 2
FKBP10 FK506 binding protein 10, 65 kDa
FN1 fibronectin 1
GAS7 growth arrest-specific 7
HIC2 hypermethylated in cancer 2
HLA-DOB major histocompatibility complex, class II, DO beta
HPS1 Hermansky-Pudlak syndrome 1
INHBA inhibin, beta A
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KRT6B keratin 6B, type II
LIMK1 LIM domain kinase 1
MAGEA5 melanoma antigen family A5
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MIIP migration and invasion inhibitory protein
MOXD1 monooxygenase, DBH-like 1
MSC musculin
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOP16 NOP16 nucleolar protein
NOX1 NADPH oxidase 1
NPTXR neuronal pentraxin receptor
NR1I3 nuclear receptor subfamily 1, group I, member 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OASL 2'-5'-oligoadenylate synthetase-like
OTOR otoraplin
PARP6 poly (ADP-ribose) polymerase family, member 6
PDE12 phosphodiesterase 12
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGP phosphoglycolate phosphatase
PLBD1 phospholipase B domain containing 1
PLCB2 phospholipase C, beta 2
PLXDC1 plexin domain containing 1
PRKG1 protein kinase, cGMP-dependent, type I
PROL1 proline rich, lacrimal 1
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RABIF RAB interacting factor
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF126P1 ring finger protein 126 pseudogene 1
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
S100A5 S100 calcium binding protein A5
SAFB scaffold attachment factor B
SAMD9 sterile alpha motif domain containing 9
SCGN secretagogin, EF-hand calcium binding protein
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SH3BP2 SH3-domain binding protein 2
SIX3 SIX homeobox 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMR3A submaxillary gland androgen regulated protein 3A
SNCG synuclein, gamma (breast cancer-specific protein 1)
STOML1 stomatin (EPB72)-like 1
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFEB transcription factor EB
TNS1 tensin 1
TP63 tumor protein p63
TRD T cell receptor delta locus
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
WT1-AS WT1 antisense RNA
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZFP64 ZFP64 zinc finger protein
ZNF518A zinc finger protein 518A
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA10 annexin A10
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARPIN actin-related protein 2/3 complex inhibitor
ASPN asporin
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAX BCL2-associated X protein
BIRC7 baculoviral IAP repeat containing 7
BMPR1B bone morphogenetic protein receptor, type IB
C4ORF29 chromosome 4 open reading frame 29
CCNO cyclin O
CD2 CD2 molecule
CD300C CD300c molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEL carboxyl ester lipase
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLEC3B C-type lectin domain family 3, member B
CLUL1 clusterin-like 1 (retinal)
CT62 cancer/testis antigen 62
CXORF21 chromosome X open reading frame 21
DEAF1 DEAF1 transcription factor
DPY19L1P1 DPY19L1 pseudogene 1
EDN1 endothelin 1
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN1 epsin 1
ERN1 endoplasmic reticulum to nucleus signaling 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKRP fukutin related protein
FOXC1 forkhead box C1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GBP2 guanylate binding protein 2, interferon-inducible
GHRH growth hormone releasing hormone
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR85 G protein-coupled receptor 85
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
IGFLR1 IGF-like family receptor 1
ITK IL2-inducible T-cell kinase
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KIAA1456 KIAA1456
KIRREL kin of IRRE like (Drosophila)
KLHL29 kelch-like family member 29
LATS1 large tumor suppressor kinase 1
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MATK megakaryocyte-associated tyrosine kinase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NRIP3 nuclear receptor interacting protein 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OVOL1 ovo-like zinc finger 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PALM paralemmin
PAQR5 progestin and adipoQ receptor family member V
PARP3 poly (ADP-ribose) polymerase family, member 3
PDCD1 programmed cell death 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEX26 peroxisomal biogenesis factor 26
PGK2 phosphoglycerate kinase 2
PMP2 peripheral myelin protein 2
PODXL2 podocalyxin-like 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRSS21 protease, serine, 21 (testisin)
QPCTL glutaminyl-peptide cyclotransferase-like
RETN resistin
RHBDD3 rhomboid domain containing 3
RHOC ras homolog family member C
RIMS1 regulating synaptic membrane exocytosis 1
RWDD3 RWD domain containing 3
SCARF1 scavenger receptor class F, member 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SENP7 SUMO1/sentrin specific peptidase 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNTA1 syntrophin, alpha 1
STMN4 stathmin-like 4
TAS2R10 taste receptor, type 2, member 10
TEP1 telomerase-associated protein 1
TFCP2L1 transcription factor CP2-like 1
THBS3 thrombospondin 3
THRB thyroid hormone receptor, beta
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TTN titin
ZNF276 zinc finger protein 276
ZNF41 zinc finger protein 41