4 iron, 4 sulfur cluster binding Gene Set

Dataset	GO Molecular Function Annotations 2025
Category	structural or functional annotations
Type	molecular function
Description	Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. (Gene Ontology, GO_0051539)
External Link	http://amigo.geneontology.org/amigo/term/GO:0051539
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Genes

17 genes performing the 4 iron, 4 sulfur cluster binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol	Name
ACO1	aconitase 1, soluble
ACO2	aconitase 2, mitochondrial
DPH1	diphthamide biosynthesis 1
DPH2	DPH2 homolog (S. cerevisiae)
ETFDH	electron-transferring-flavoprotein dehydrogenase
EXO5	exonuclease 5
IREB2	iron-responsive element binding protein 2
ISCA2	iron-sulfur cluster assembly 2
METTL17	methyltransferase like 17
MOCS1	molybdenum cofactor synthesis 1
NFU1	NFU1 iron-sulfur cluster scaffold
NUBPL	nucleotide binding protein-like
POLR3F	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PRIM2	primase, DNA, polypeptide 2 (58kDa)
RSAD1	radical S-adenosyl methionine domain containing 1
RSAD2	radical S-adenosyl methionine domain containing 2
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)