4-hydroxyproline metabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. (Gene Ontology, GO_0019471)
External Link http://amigo.geneontology.org/amigo/term/GO:0019471
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Genes

6 genes participating in the 4-hydroxyproline metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
EGLN2 egl-9 family hypoxia-inducible factor 2
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PRODH proline dehydrogenase (oxidase) 1